Results 81 to 90 of about 11,382,550 (291)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Approximation of Cumulative Distribution Functions by Bernstein Phase-Type Distributions
Performance EvaluationThe inclusion of generally distributed random variables in stochastic models is often tackled by choosing a parametric family of distributions and applying fitting algorithms to find appropriate parameters. A recent paper proposed the approximation of probability density functions (PDFs) by Bernstein exponentials, which are obtained from Bernstein ...
András Horváth +4 more
openaire +4 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Numerical evidence for phase transitions of NP-complete problems for instances drawn from Lévy-stable distributions [PDF]
, 2011 Random NP-Complete problems have come under study as an important tool used in the analysis of optimization algorithms and help in our understanding of how to properly address issues of computational intractability.
Connelly, Abram, Abram Connelly
core +2 more sources
Advances in High Energy Physics, 2015 We propose a new revised Landau hydrodynamic model to study systematically the pseudorapidity distributions of charged particles produced in heavy ion collisions over an energy range from a few GeV to a few TeV per nucleon pair. The interacting system is
Li-Na Gao, Fu-Hu Liu
doaj +1 more source
Phase-Type Models in Life Insurance: Fitting and Valuation of Equity-Linked Benefits
Risks, 2019 Phase-type (PH) distributions are defined as distributions of lifetimes of finite continuous-time Markov processes. Their traditional applications are in queueing, insurance risk, and reliability, but more recently, also in finance and, though to a ...
Søren Asmussen +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Sequence Discrimination Using Phase-Type Distributions [PDF]
, 2006 We propose in this paper a novel approach to the classification of discrete sequences. This approach builds a model fitting some dynamical features deduced from the learning sample. These features are discrete phase-type (PH) distributions. They model the first passage times (FPT) between occurrences of pairs of substrings.
Jérôme Callut, Pierre Dupont
openaire +2 more sources
Magnetic and nematic phases in a Weyl type spin–orbit-coupled spin-1 Bose gas
New Journal of Physics, 2016 We present a variational study of the spin-1 Bose gases in a harmonic trap with three-dimensional spin–orbit (SO) coupling of Weyl type. For weak SO coupling, we treat the single-particle ground states as the form of perturbational harmonic oscillator ...
Guanjun Chen, Li Chen, Yunbo Zhang
doaj +1 more source