Results 71 to 80 of about 5,261,050 (250)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Direct sampling of the Susskind-Glogower phase distributions

, 1996
Coarse-grained phase distributions are introduced that approximate to the Susskind--Glogower cosine and sine phase distributions. The integral relations between the phase distributions and the phase-parametrized field-strength distributions observable in
A. Zucchetti, D.-G. Welsch, D.T. Smithey, D.T. Smithey, D.T. Smithey, G. Breitenbach, G.M. D'Ariano, G.M. D'Ariano, G.M. D'Ariano, H. Kühn, J.W. Noh, J.W. Noh, J.W. Noh, J.W. Noh, J.W. Noh, J.W. Noh, K. Vogel, K.E. Cahill, L. Knöll, L. Susskind, M. Beck, M. Dakna, M. Dakna, M. Munroe, M. Schubert, M.G. Raymer, P. Carruthers, P. Carruthers, R. Loudon, R. Lynch, S. Schiller, Th. Richter, U. Leonhardt, U. Leonhardt   +33 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Deconfinement Phase Transition in Neutron Stars and \delta-Meson Field

, 2012
The Maxwell and Glendenning construction scenarios of deconfinement phase transition in neutron star matter are investigated. The hadronic phase is described within the relativistic mean-field (RMF) theory, if also the scalar-isovector \delta-meson field
Alaverdyan, A. G., Alaverdyan, G. B., Chiladze, A. O.   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Universal Dynamics of Phase-Field Models for Dendritic Growth

, 1998
We compare time-dependent solutions of different phase-field models for dendritic solidification in two dimensions, including a thermodynamically consistent model and several ad hoc models.
A. A. Wheeler, A. Karma, A. Karma, A. Karma, D. A. Kessler, G. Caginalp, G. Caginalp, G. Caginalp, G. Caginalp, J. A. Warren, J. B. Collins, J. Langer, J. S. Langer, J. S. Langer, Jonathan Dantzig, M. E. Glicksman, M. Fabbri, N. Provatas, N. Provatas, Nigel Goldenfeld, Nikolas Provatas, O. Penrose, R. Kobayashi, S.-C. Huang, S.-L. Wang, S.-L. Wang, Yung-Tae Kim   +26 more
core   +1 more source

Propagating phase interface with intermediate interfacial phase: Phase field approach

Physical Review B, 2014
An advanced three-phase phase field approach (PFA) is suggested for a nonequilibrium phase interface that contains an intermediate phase, in particular, a solid-solid interface with a nanometer-sized intermediate melt (IM). A thermodynamic potential in the polar order parameters is developed that satisfies all thermodynamic equilibrium and stability ...
Momeni, Kasra, Levitas, Valery
openaire   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source