Results 81 to 90 of about 491,257 (266)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Precision Construction of Chiral Optical Fields with Nine Controllable Degrees of Freedom

Advanced Photonics Research
Recently, chiral optical fields (COFs) have garnered significant attention due to their multiple controllable degrees of freedom (DOFs), enabling applications in diverse areas such as optical tweezers, manufacturing, and holographic encryption.
Duo Deng, Xing Liu, Zixin Xu, Zhenjun Yang, Yan Li   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Advanced biological imaging techniques based on metasurfaces

Opto-Electronic Advances
Advanced imaging techniques have been widely used in various biological studies. Currently, numerous imaging modalities are utilized in biological applications, including medical imaging, diagnosis, biometrics, and fundamental biological research ...
Yongjae Jo, Hyemi Park, Hyeyoung Yoon, Inki Kim   +3 more
doaj   +1 more source

Improving radar performance with constant envelope multi-level chirp

Tehnički Glasnik, 2019
M-level Continuous Phase Chirp Modulation is considered for data transmission. In this article, we would like to propose a new approach to transmitting information with the help of multi-level wave guide signaling. The main problem with the classic chirp
Farhad Bahadori-Jahromi, Alireza Hassannejad   +1 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Multi-mode single sideband time modulation harmonic adaptive beamforming

Zhongguo Jianchuan Yanjiu
ObjectiveThis study proposes an innovative beamforming method to achieve high-efficiency harmonic adaptive beamforming through multi-mode single sideband time modulation technology.MethodA multi-mode single sideband time modulation module containing ...
Tao YANG, Xiaonan ZHAO, Zhenji LIU, Tingting FAN, Liu YANG, Yu XIA, Jingfeng CHEN   +6 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Broadband SAR Imaging Based on Narrowband Dense False Target Jamming

Remote Sensing
To meet the multi-device integration requirements faced by electronic warfare systems in the current environment and to address the problem of conventional jamming-based imaging algorithms being unable to achieve a high range resolution under narrowband ...
Gaogao Liu, Ziyu Huang, Haoran Pan, Qidong Zhang, Jiangbo Zhu   +4 more
doaj   +1 more source