Results 91 to 100 of about 574,951 (322)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Phase Retrieval Using Unitary 2-Designs
, 2017 We consider a variant of the phase retrieval problem, where vectors are replaced by unitary matrices, i.e., the unknown signal is a unitary matrix U, and the measurements consist of squared inner products |Tr(C*U)|^2 with unitary matrices C that are ...
Kimmel, Shelby, Liu, Yi-Kai
core +1 more source
Set projection algorithms for blind ptychographic phase retrieval [PDF]
, 2023 Wenjie Mei, Andrew Maiden
openalex +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Phase retrieval from low-rate samples [PDF]
, 2014 The paper considers the phase retrieval problem in N-dimensional complex vector spaces. It provides two sets of deterministic measurement vectors which guarantee signal recovery for all signals, excluding only a specific subspace and a union of subspaces,
Boche, Holger, Pohl, Volker, Yang, Fanny
core
Benchmark Problems for Phase Retrieval [PDF]
SIAM Journal on Imaging Sciences, 2018 27 pages, 10 figures, new references, modified appendix, improved ...
Veit Elser, Ti-Yen Lan, Tamir Bendory
openaire +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Phase retrieval by coherent modulation imaging
Nature Communications, 2016 Robust coherent diffractive imaging generally requires many exposures that may damage samples. Here, the authors develop a single-shot X-ray imaging method applicable to general samples for materials and biological sciences, also enabling imaging of ...
Fucai Zhang +5 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source