Results 61 to 70 of about 573,440 (274)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Linear phase retrieval for real-time adaptive optics [PDF]
Journal of the European Optical Society-Rapid Publications, 2013 We developed a fast phase retrieval algorithm that is suitable for real-time applications such as adaptive optics. The phase retrieval model is developed by linearising the pupil function in the approximation of small aberrations and is valid for low-NA ...
Polo A. +4 more
doaj +1 more source
Time evolution of the extremely diluted Blume-Emery-Griffiths neural network [PDF]
, 2002 The time evolution of the extremely diluted Blume-Emery-Griffiths neural network model is studied, and a detailed equilibrium phase diagram is obtained exhibiting pattern retrieval, fluctuation retrieval and self-sustained activity phases.
Bolle', D. +4 more
core +5 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
PhaseMax: Convex Phase Retrieval via Basis Pursuit
, 2018 We consider the recovery of a (real- or complex-valued) signal from magnitude-only measurements, known as phase retrieval. We formulate phase retrieval as a convex optimization problem, which we call PhaseMax.
Goldstein, Tom, Studer, Christoph
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Ptychographic phase retrieval by proximal algorithms
New Journal of Physics, 2020 We derive a set of ptychography phase-retrieval iterative engines based on proximal algorithms originally developed in convex optimization theory, and discuss their connections with existing ones.
Hanfei Yan
doaj +1 more source
, 2021 We study a bandit version of phase retrieval where the learner chooses actions $(A_t)_{t=1}^n$ in the $d$-dimensional unit ball and the expected reward is $\langle A_t, _\star\rangle^2$ where $ _\star \in \mathbb R^d$ is an unknown parameter vector. We prove that the minimax cumulative regret in this problem is $\smash{\tilde (d \sqrt{n})}$, which
Lattimore, Tor, Hao, Botao
openaire +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Ab initio compressive phase retrieval
, 2008 Any object on earth has two fundamental properties: it is finite, and it is made of atoms. Structural information about an object can be obtained from diffraction amplitude measurements that account for either one of these traits. Nyquist-sampling of the
Marchesini, S.
core +1 more source