Results 121 to 130 of about 6,760 (299)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Butler Matrix Based on Substrate Integrated Waveguide Without Crossover and Phase Shifter for Millimeter Waves Applications [version 2; peer review: 1 approved, 2 approved with reservations]

F1000Research
Background A novel low-loss 4 × 4 Butler Matrix structure for 26 GHz operation is designed in this study. The proposed 4 × 4 antenna Butler matrix comprises an inscribed structure, which makes it fundamentally different from traditional beam-forming ...
Zahriladha Zakaria, Hussam Keriee, Kim Geok Tan, Nawres Nayyef, Chockalingam Aravind Vaithilingam, Chia Pao Liew   +5 more
doaj   +1 more source

Variable-Ratio Mode-Insensitive 1 × 2 Power Splitter Based on MMI Couplers and Phase Shifters

IEEE Photonics Journal, 2018
Mode-division multiplexing (MDM) has been considered as a low-cost and high-density means for high-bandwidth on-chip optical communications in a high-performance computer and a data center.
Fang Ren, Wei Chen, Tianwen Zhangsun, Yiying Zhang, Xiaojie Fan, Jianping Wang   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Guided resonance reflective phase shifters [PDF]

, 2015
We present reflective phase shifters based on high contrast gratings resting on a low-index spacer backed by a metallic mirror. The guided resonance of the grating combined with the reflection from the metallic mirror leads to an all-pass filter with 2π ...
Yu Horie, Amir Arbabi, Arbabi, Amir, Faraon, Andrei, Andrei Faraon, Horie, Yu   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

E-Band Beam-Steerable and Scalable Phased Antenna Array for 5G Access Point

International Journal of Antennas and Propagation, 2018
This paper presents a new implementation of the beam-steerable two-dimensional phased antenna array for the forthcoming 5G networks. The antenna enables easy integration of phase shifters and other active electronics on a single PCB, low-loss feed ...
Md. Mazidul Islam, Mikko Leino, Rasmus Luomaniemi, Jinsong Song, Risto Valkonen, Juha Ala-Laurinaho, Ville Viikari   +6 more
doaj   +1 more source

Thermo-optic phase shifters based on silicon-on-insulator platform: state-of-the-art and a review. [PDF]

Front Optoelectron, 2022
Liu S, Feng J, Tian Y, Zhao H, Jin L, Ouyang B, Zhu J, Guo J.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Novel Phase Shifters Using Reconfigurable Filters [PDF]

Phase shifters play a crucial role in radar, satellite communications, and 5G networks. Recently, the idea of using filters as phase shifters have attracted much interest due to providing many benefits such as smaller area, lower noise figure, easier ...
Brussenskiy, Georgiy
core   +1 more source