Results 151 to 160 of about 7,348,255 (319)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Bifurcations in the regularized Ericksen bar model

, 2007
We consider the regularized Ericksen model of an elastic bar on an elastic foundation on an interval with Dirichlet boundary conditions as a two-parameter bifurcation problem.
Lord, G.J., Lord, G. J., M. Grinfeld, G. J. Lord, Grinfeld, M.   +4 more
core   +1 more source

Phase singular point localization of vortex beam using optical correlation

JPhys Photonics
The study of optical vortex beams has garnered significant attention due to their wide-ranging applications. These beams exhibit a phase singularity and accurately identifying the location of the singular point is crucial for various vortex-based ...
Allarakha Shikder, Akash Pal, Naveen K Nishchal   +2 more
doaj   +1 more source

Prospective cross-sectional study using Poisson renewal theory to study phase singularity formation and destruction rates in atrial fibrillation (RENEWAL-AF): Study design. [PDF]

J Arrhythm, 2020
Quah J, Dharmaprani D, Lahiri A, Schopp M, Mitchell L, Selvanayagam JB, Perry R, Chahadi F, Tung M, Ahmad W, Stoyanov N, Joseph MX, Singleton C, McGavigan AD, Ganesan AN.   +14 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Singularity of the specific heat of two-dimensional random Ising models

, 1998
The singularity of the specific heat is studied for the dilution (J>J'>0) type and Gaussian type random Ising models using the Pfaffian method numerically.
M. Inoue
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Observation of a phase shift in nonlinear parity-time symmetric film bulk acoustic resonators

Physical Review Research
An exceptional point (EP) in PT (parity-time)-symmetric systems featuring loss and nonlinear saturable gain has been recently utilized to enhance sensing, leading to the cube-root singularity in a two-level system.
Zhenyu Wei, Jian-Qiu Huang, Mengting Wang, Qing-An Huang   +3 more
doaj   +1 more source

Two lectures on Yang-Lee edge singularity and analytic structure of QCD equation of state

SciPost Physics Lecture Notes
These lecture notes, prepared for the 2024 XQCD PhD, provide an introduction to the analytic structure of an equation of state near a second-order phase transition and its most prominent landmark: the Yang-Lee edge singularity.
Vladimir V. Skokov
doaj   +1 more source