Results 131 to 140 of about 7,348,255 (319)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Localization of nanoscale objects with light singularities
NanophotonicsUnprecedented atomic-scale measurement resolution has recently been demonstrated in single-shot optical localization measurements based on deep-learning analyses of diffraction patterns of topologically structured light scattered from objects.
Grant Thomas A. +4 more
doaj +1 more source
Incoherent Shock and Collapse Singularities in Non-Instantaneous Nonlinear Media
Applied Sciences, 2018 We study the dynamics of a partially incoherent optical pulse that propagates in a slowly responding nonlinear Kerr medium. We show that irrespective of the sign of the dispersion (either normal or anomalous), the incoherent pulse as a whole exhibits a ...
Gang Xu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Electric field singularity assisted nanopatterning
, 2004 Ordered arrays of Pt nanoparticles (see Figure) have been produced on a reconstructed alumina surface that serves as a template for nanopatterning.
Shenoy, V. B. +2 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Thermogeometric phase transition in a unified framework
Physics Letters B, 2017 Using geomterothermodynamics (GTD), we investigate the phase transition of black hole in a metric independent way. We show that for any black hole, curvature scalar (of equilibrium state space geometry) is singular at the point where specific heat ...
Rabin Banerjee +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
On Spinfoams Near a Classical Curvature Singularity
, 2016 We apply the technique of spinfoam to study the space-time which, classically, contains a curvature singularity. We derive from the full covariant Loop Quantum Gravity (LQG) that the region near curvature singularity has to be of strong quantum gravity ...
Han, M., Zhang min, M.
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source