Results 71 to 80 of about 826,806 (318)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Phase transition dynamics for hot nuclei

Physics Letters B, 2018
An abnormal production of events with almost equal-sized fragments was theoretically proposed as a signature of spinodal instabilities responsible for nuclear multifragmentation in the Fermi energy domain.
B. Borderie, N. Le Neindre, M.F. Rivet, P. Désesquelles, E. Bonnet, R. Bougault, A. Chbihi, D. Dell'Aquila, Q. Fable, J.D. Frankland, E. Galichet, D. Gruyer, D. Guinet, M. La Commara, I. Lombardo, O. Lopez, L. Manduci, P. Napolitani, M. Pârlog, E. Rosato, R. Roy, P. St-Onge, G. Verde, E. Vient, M. Vigilante, J.P. Wieleczko   +25 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Quantum Phase Transitions

, 2000
These are notes for lectures delivered at the NATO ASI on Dynamics in Leiden, The Netherlands, in July 1998. The main concepts relating to quantum phase transitions are explained, using the paramagnet-to-ferromagnet transition of itinerant electrons as the primary example. Some aspects of metal-insulator transitions are also briefly discussed.
Dietrich Belitz, T. R. Kirkpatrick
openaire   +3 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Photonic topological phase transition on demand

Nanophotonics, 2019
On-demand, switchable phase transitions between topologically nontrivial and trivial photonic states are demonstrated. Specifically, it is shown that the integration of a two-dimensional array of coupled ring resonators within a thermal heater array ...
Kudyshev Zhaxylyk A., Kildishev Alexander V., Boltasseva Alexandra, Shalaev Vladimir M.   +3 more
doaj   +1 more source

Negative Thermal Expansion Near the Precipice of Structural Stability in Open Perovskites

Frontiers in Chemistry, 2018
Negative thermal expansion (NTE) describes the anomalous propensity of materials to shrink when heated. Since its discovery, the NTE effect has been found in a wide variety of materials with an array of magnetic, electronic and structural properties.
Connor A. Occhialini, Connor A. Occhialini, Gian G. Guzmán-Verri, Gian G. Guzmán-Verri, Sahan U. Handunkanda, Sahan U. Handunkanda, Jason N. Hancock, Jason N. Hancock   +7 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Shock-induced phase transition of iron studied with phase field method

International Journal of Multiphysics, 2018
To develop phase field method in high strain rate loading, it derived the governing equations of phase field model in the foundation of entropy functional, and the model adopted a diffusion interface, which made automatic tracking on interface possible ...
Z Wang, X Guo, D Zhao, Q Zhang
doaj   +1 more source