Results 131 to 140 of about 84,152 (313)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The discriminant power of bubble wall velocities: gravitational waves and electroweak baryogenesis

Journal of High Energy Physics
A precise determination of the bubble wall velocity v w is crucial for making accurate predictions of the baryon asymmetry and gravitational wave (GW) signals in models of electroweak baryogenesis (EWBG).
Marcela Carena, Aurora Ireland, Tong Ou, Isaac R. Wang   +3 more
doaj   +1 more source

Initial conditions for GRMHD simulations of electroweak and QCD phase transitions in the early Universe

, 2023
J. M. Barrera, Aleisha Warren, David Garrison   +2 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Primordial black holes as dark matter: interferometric tests of phase transition origin

Journal of High Energy Physics
We show that primordial black holes — in the observationally allowed mass window with f PBH = 1 — formed from late nucleating patches in a first order phase transition imply upcoming gravitational wave interferometers will see a large stochastic ...
Iason Baldes, María Olalla Olea-Romacho
doaj   +1 more source

Card games are effective tools to enhance foundation year health and safety inductions

FEBS Open Bio, EarlyView.
A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq, Holly Matthews, Daniya Abedalreza, Faten Yahya, Matthew Allan Jones   +4 more
wiley   +1 more source

Gravitational waves from phase transitions and cosmic strings in neutrino mass models with multiple majorons

Journal of High Energy Physics
We explore the origin of Majorana masses within the majoron model and how this can lead to the generation of a distinguishable primordial stochastic background of gravitational waves.
Pasquale Di Bari, Stephen F. King, Moinul Hossain Rahat   +2 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

A Little Inflation in the Early Universe at the QCD Phase Transition [PDF]

, 2010
Tillmann Boeckel, Jürgen Schaffner‐Bielich   +1 more
openalex   +1 more source