Results 121 to 130 of about 154,633,936 (258)
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Journal of High Energy PhysicsWe explore the cosmological dynamics of a supercooled first-order phase transition in the classically conformal U(1) B−L extension of the Standard Model, where radiative symmetry breaking simultaneously generates the right-handed neutrino (RHN) masses ...
Peter Athron +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Phase transitions in polymers : the role of metastable states /
, 2008 A classical metastable state possesses a local free energy minimum at infinite sizes, but not a global one. This concept is phase size independent. We have studied a number of experimental results and proposed a new concept that there exists a wide range
Cheng, Stephen Z. D.
core
First order phase transitions in cosmology
, 1999 We review the observable effects produced by phase transitions occurring along with inflation. Firstly, we present a model which is able to generate a locally open universe as the result of a very early phase transition peaked at a precise epoch.
Baccigalupi, C. +7 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Inverse electroweak baryogenesis
Journal of High Energy PhysicsWe propose a mechanism for baryogenesis in which the baryon asymmetry is generated as an equilibrium response of weak sphalerons in a region where electroweak sphaleron transitions remain unsuppressed, h/T ≲ 1. A nonzero equilibrium baryon density arises
Jacopo Azzola +2 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Soliton foam formation in the early Universe
The formation of composite solitons produced by scalar fields without thermal phase transitions in the early Universe is considered. We present numerical simulations of the formation and evolution of soliton structures at the post-inflationary stage. The
Murygin, B. S. +5 more
core +1 more source