Results 121 to 130 of about 88,270 (291)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Gravitational wave signatures from lepton number breaking phase transitions with flat potentials

Journal of High Energy Physics
Extensions of the Standard Model typically contain “flaton fields” defined as fields with large vacuum expectation values and almost flat potentials where scalar self-coupling is small or vanishes at tree level.
Gabriela Barenboim, Yeji Park, Liliana Velasco-Sevilla   +2 more
doaj   +1 more source

Generalized inflation and confinement phase transitions in the early universe

Zeitschrift f�r Physik C Particles and Fields, 1989
Giving up the restriction e/p=const, we show that equations of state with e−3p=Δ>0 will be driven to the inflationary solution with e=−p after sufficiently long times. Subsequently, we show that confinement transitions may provide such an equation of state due to a change of degrees of freedom.
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

RGE effects on new physics searches via gravitational waves

Journal of High Energy Physics
Gravitational wave (GW) observations offer a promising probe of new physics associated with a first-order electroweak phase transition. Precision studies of the Higgs potential, including Fisher matrix analyses, have been extensively conducted in this ...
Katsuya Hashino, Daiki Ueda
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The bubble wall velocity in local thermal equilibrium and energy budget with full effective potential

Journal of High Energy Physics
We develop a framework based on the full one-loop finite-temperature effective potential model, within which the bubble wall velocity is calculated using the local thermal equilibrium (LTE) approximation, and the kinetic energy fraction K is computed ...
Zongguo Si, Hongxin Wang, Lei Wang, Yang Xiao, Yang Zhang   +4 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Phase Transition in the Early Universe and Charge Quantisation

, 1995
It is shown, for the first time , that surprisingly the electric charge loses all physical meaning above the electro-weak phase transition temperature. Implications of this discovery in the context of the early universe within the framework of various unified models are discussed.
openaire   +2 more sources