Results 101 to 110 of about 154,633,936 (258)

Investigating the Electroweak phase transition with a real scalar singlet at a muon collider

Journal of High Energy Physics
A strong first-order electroweak phase transition (SFOEWPT) is essential for explaining baryogenesis, and for potentially generating observable gravitational waves.
Mohamed Aboudonia, Csaba Balazs, Andreas Papaefstathiou, Graham White   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Gravitational waves from flavoured SU(2) early-universe phase transitions

International audienceFlavourful extensions of the Standard Model aimed at explaining its fermionic mass structure typically rely on symmetries, broken at high-energy scales far beyond the reach of foreseeable direct collider searches.
Deandrea, Aldo, Darmé, Luc, Chrysostomou, Anna, Cornell, Alan S, Demartini, Thibault   +4 more
core   +3 more sources

Gravitational wave signatures from lepton number breaking phase transitions with flat potentials

Journal of High Energy Physics
Extensions of the Standard Model typically contain “flaton fields” defined as fields with large vacuum expectation values and almost flat potentials where scalar self-coupling is small or vanishes at tree level.
Gabriela Barenboim, Yeji Park, Liliana Velasco-Sevilla   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Phase transitions as the origin of large scale structure in the universe [PDF]

, 1988
A review of the formation of large scale structure through gravitational growth of primordial perturbations is given. This is followed by a discussion of how symmetry breaking phase transitions in the early universe might have produced the required ...
Turok, Neil, Turok, N.
core  

Bounds from D/H on baryogenesis models

Journal of High Energy Physics
We review the constraints on baryon inhomogeneities derived from measurements of the deuterium abundance, D/H, and apply them to a range of baryogenesis models.
Aleksandr Azatov, Bruno Missoni
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The early universe

, 1990
The Early Universe has become the standard reference on forefront topics in cosmology, particularly to the early history of the Universe. Subjects covered include primordial nubleosynthesis, baryogenesis, phases transitions, inflation, dark matter, and ...
Kolb, Edward W, Turner, Michael Stanley
core   +1 more source