Results 91 to 100 of about 88,270 (291)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Bubble nucleation from boson star collapse

Journal of High Energy Physics
We present a new classical mechanism for nucleation of bubbles of true vacuum. The mechanism arises when dense boson stars form in the false vacuum.
Aleksandr Azatov, Takeshi Kobayashi, Nicklas Ramberg   +2 more
doaj   +1 more source

The First Magnetic Fields

, 2011
We review current ideas on the origin of galactic and extragalactic magnetic fields. We begin by summarizing observations of magnetic fields at cosmological redshifts and on cosmological scales.
A. Brandenburg, A. Kosowsky, A. Lazarian, A. Lewis, A. Mack, A. Neronov, A. Rebhan, A. Yahil, A.A. Starobinskii, A.H. Guth, A.J. Keane, B. Cheng, B. Himmetoglu, B. Himmetoglu, B. Ratra, B. Schenke, B.D. Fried, C. Bonvin, C. Caprini, C. Pinto, C. Pinto, C.D. Dermer, C.G. Tsagas, C.G. Tsagas, C.G. Tsagas, C.J. Hogan, C.L. Carilli, Christos G. Tsagas, D. Grasso, D.G. Yamazaki, D.H. Lyth, D.R.G. Schleicher, D.R.G. Schleicher, D.R.G. Schleicher, D.T. Son, Dominik R. G. Schleicher, Dongsu Ryu, E. Fenu, E. Weibel, E.-J. Kim, E.W. Kolb, F. Finelli, F. Hoyle, F. Hoyle, G. Davies, G. Sigl, G.B. Field, H. Maki, H. Stefani, H. Tashiro, H. Tashiro, H. Xu, I. Brown, J. Adamek, J. Adams, J. Martin, J. Silk, J. Silk, J.-P. Blaizot, J.A. Peacock, J.A. Quashnock, J.C. Tan, J.D. Barrow, J.D. Barrow, J.D. Barrow, J.D. Jackson, J.M. Cornwall, J.R. Shaw, K. Ichiki, K. Jedamzik, K. Jedamzik, K. Subramanian, K. Subramanian, K. Subramanian, K. Subramanian, K. Subramanian, K. Subramanian, K. Subramanian, K. Takahashi, K. Thorne, K.-T. Kim, Kandaswamy Subramanian, L. Biermann, L.F.S. Rodrigues, L.M. Widrow, Lawrence M. Widrow, M. Ando, M. Christensson, M. Gasperini, M. Giovannini, M. Langer, M. Strickland, M. Strickland, M.A. Stenrup, M.J. Rees, M.J. Rees, M.L. Bernet, M.N. Machida, M.S. Turner, M.V. Penston, N.Y. Gnedin, P. Anninos, P. Arnold, P. Arnold, P. Arnold, P. Arnold, P. Arnold, P. Hennebelle, P. Hennebelle, P. Romatschke, P.J. Greenberg, P.J.E. Peebles, P.J.E. Peebles, P.P. Kronberg, P.P. Kronberg, P.P. Kronberg, R. Banerjee, R. Banerjee, R. Banerjee, R. Durrer, R. Durrer, R. Durrer, R. Durrer, R.-G. Cai, R.A. Daly, R.B. Larson, R.E. Pudritz, R.M. Athreya, R.M. Kulsrud, R.M. Kulsrud, Rudolf A. Treumann, S. Bethke, S. Seager, S. Sur, S.C.O. Glover, S.D.M. White, S.I. Syrovatskii, S.K. Sethi, S.W. Hawking, St. Mrówczyński, St. Mrówczyński, T. Abel, T. Abel, T. Kahniashvili, T. Vachaspati, T.R. Seshadri, T.R. Seshadri, U. Frisch, V. Bromm, V. Demozzi, Ya.B. Zel’dovich, Yu.E. Pokrovsky   +151 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Revisiting metastable cosmic string breaking

Journal of High Energy Physics
Metastable cosmic strings appear in models of new physics with a two-step symmetry breaking G → H → 1, where π 1(H) ≠ 0 and π 1(G) = 0. They decay via the monopole-antimonopole pair creation inside. Conventionally, the breaking rate has been estimated by
Akifumi Chitose, Masahiro Ibe, Yuhei Nakayama, Satoshi Shirai, Keiichi Watanabe   +4 more
doaj   +1 more source

Hearing the echoes of electroweak baryogenesis with gravitational wave detectors

, 2016
We report on the first joint analysis of observational signatures from the electroweak baryogenesis in both gravitational wave (GW) detectors and particle colliders.
Cai, Yi-Fu, Huang, Fa Peng, Wan, Youping, Wang, Dong-Gang, Zhang, Xinmin   +4 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A Tale of Two Timescales: Mixing, Mass Generation, and Phase Transitions in the Early Universe

, 2015
Light scalar fields such as axions and string moduli can play an important role in early-universe cosmology. However, many factors can significantly impact their late-time cosmological abundances.
Dienes, Keith R., Kost, Jeff, Thomas, Brooks   +2 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Generic features of vacuum phase transitions in the early universe

Nuclear Physics B, 1990
Abstract A simple Higgs model is utilized to show the occurrence of a four-phase pattern of vacuum symmetry. As temperature changes, an interplay of spontaneous symmetry breaking and spontaneous symmetry restoration ensues, and resonant field interchange occurs.
T.W. Kephart, T.J. Weiler, T.-C. Yuan
openaire   +1 more source