Results 91 to 100 of about 1,845 (260)

Investigating the Electroweak phase transition with a real scalar singlet at a muon collider

Journal of High Energy Physics
A strong first-order electroweak phase transition (SFOEWPT) is essential for explaining baryogenesis, and for potentially generating observable gravitational waves.
Mohamed Aboudonia, Csaba Balazs, Andreas Papaefstathiou, Graham White   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Gravitational wave signatures from lepton number breaking phase transitions with flat potentials

Journal of High Energy Physics
Extensions of the Standard Model typically contain “flaton fields” defined as fields with large vacuum expectation values and almost flat potentials where scalar self-coupling is small or vanishes at tree level.
Gabriela Barenboim, Yeji Park, Liliana Velasco-Sevilla   +2 more
doaj   +1 more source

Phase transitions and the birth of early universe particle physics

Studies in History and Philosophy of Science
This paper provides a conceptual history of the development of early universe particle physics in the 1970s, focusing on the development of more sophisticated tools for constructing gauge-theories at finite-temperature. I start with a focus on early investigations into spontaneous symmetry restoration, and continue through the development of functional
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

RGE effects on new physics searches via gravitational waves

Journal of High Energy Physics
Gravitational wave (GW) observations offer a promising probe of new physics associated with a first-order electroweak phase transition. Precision studies of the Higgs potential, including Fisher matrix analyses, have been extensively conducted in this ...
Katsuya Hashino, Daiki Ueda
doaj   +1 more source

Correction: Phase transitions in the early universe

SciPost Physics Lecture Notes, 2021
Mark Hindmarsh, Marvin Lüben, Johannes Lumma, Martin Pauly   +3 more
openaire   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source