Results 71 to 80 of about 154,633,936 (258)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Cosmological phase transitions from the functional measure

Journal of High Energy Physics
We investigate how competitive gravitational wave detectors can be to current and near-future colliders in probing a model where the new physics is completely encapsulated in a modified scalar sector.
Bruno Berganholi, Gláuber C. Dorsch, Iberê Kuntz, Beatriz M. D. Sena, Giovanna F. do Valle   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Walls, bubbles and doom — the cosmology of HEFT

Journal of High Energy Physics
As experiment charts new territory at the electroweak scale, the enterprise to characterise all possible theories becomes all the more necessary. In the absence of new particles, this ambitious enterprise is attainable and has led to the Higgs Effective ...
R. Alonso, J.C. Criado, R. Houtz, M. West   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Quark-hadron phase transitions in the viscous early universe [PDF]

, 2012
In the standard hot big bang theory, when the Universe was about 1-10μs old, the cosmological matter is conjectured to undergo quantum chromodynamics (QCD) phase transition(s) from quark matter to hadrons.
Tawfik, T, Harko, TC
core   +1 more source

Bubble nucleation from boson star collapse

Journal of High Energy Physics
We present a new classical mechanism for nucleation of bubbles of true vacuum. The mechanism arises when dense boson stars form in the false vacuum.
Aleksandr Azatov, Takeshi Kobayashi, Nicklas Ramberg   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Revisiting metastable cosmic string breaking

Journal of High Energy Physics
Metastable cosmic strings appear in models of new physics with a two-step symmetry breaking G → H → 1, where π 1(H) ≠ 0 and π 1(G) = 0. They decay via the monopole-antimonopole pair creation inside. Conventionally, the breaking rate has been estimated by
Akifumi Chitose, Masahiro Ibe, Yuhei Nakayama, Satoshi Shirai, Keiichi Watanabe   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source