Results 61 to 70 of about 149,223,535 (289)
On the origin and evolution of life in the Galaxy [PDF]
, 2010 A simple stochastic model for evolution, based upon the need to pass a sequence of n critical steps is applied to both terrestrial and extraterrestrial origins of life. In the former case, the time at which humans have emerged during the habitable period
McCabe, Michael +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Gravitational waves-tomography of Low-Scale-Leptogenesis
Journal of High Energy Physics, 2022 A long-lived scalar field (Φ) which couples weakly to the right-handed (RH) neutrinos (N Ri ), generates small RH neutrino masses (M i ) in Low-Scale-Leptogenesis (LSL) mechanisms, despite having a large vacuum expectation value v Φ.
Satyabrata Datta, Rome Samanta
doaj +1 more source
Phase Transitions in Finite Systems [PDF]
, 2005 This paper examines the apparent paradox in the fact that all successful theoretical treatments of phase transitions require an infinite system, yet they are clearly seen to occur in finite systems in the real world.
Mainwood, Paul
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A continuum model for the dynamics of the phase transition from slow-wave sleep to REM sleep [PDF]
, 2010 Previous studies have shown that activated cortical states (awake and rapid eye-movement (REM) sleep), are associated with increased cholinergic input into the cerebral cortex.
Voss, Logan J. +5 more
core +1 more source
Steady-state bubbles beyond local thermal equilibrium
Journal of High Energy PhysicsWe investigate the hydrodynamic solutions for expanding bubbles in cosmological first-order phase transitions going beyond local thermal equilibrium approximation.
Tomasz Krajewski +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
WallGo investigates: Theoretical uncertainties in the bubble wall velocity
Journal of High Energy PhysicsWe examine theoretical uncertainties in state-of-the-art calculations of the bubble wall velocity during first-order cosmological phase transitions.
Jorinde van de Vis +5 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source