Results 61 to 70 of about 1,845 (260)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Conformal phase transition in supersymmetric QCD

Journal of High Energy Physics
We construct a four-dimensional supersymmetric QCD in conformal window with a marginally relevant deformation which triggers the spontaneous breaking of (approximate) scale invariance and the subsequent confinement, generating a mass gap, at an energy ...
Kohei Fujikura, Shota Nakagawa, Yuichiro Nakai, Peng Sun, Yufei Zhang   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cosmological phase transitions from the functional measure

Journal of High Energy Physics
We investigate how competitive gravitational wave detectors can be to current and near-future colliders in probing a model where the new physics is completely encapsulated in a modified scalar sector.
Bruno Berganholi, Gláuber C. Dorsch, Iberê Kuntz, Beatriz M. D. Sena, Giovanna F. do Valle   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Walls, bubbles and doom — the cosmology of HEFT

Journal of High Energy Physics
As experiment charts new territory at the electroweak scale, the enterprise to characterise all possible theories becomes all the more necessary. In the absence of new particles, this ambitious enterprise is attainable and has led to the Higgs Effective ...
R. Alonso, J.C. Criado, R. Houtz, M. West   +3 more
doaj   +1 more source

Braneworld Graviton Interactions in Early Universe Phase Transitions

, 2007
These are proceedings for the Les Houches Summer School ``Particle Physics and Cosmology: the Fabric of Spacetime,'' held in Les Houches, France, July 31--August 25, 2006. We summarise the discussions of our working group and outline a procedure for calculating gravity corrections to scalar field potentials, as they might be relevant for inflationary ...
Ansari, Rizwan U. H., Delaunay, Cedric, Gwyn, Rhiannon, Knauf, Anke, Sellerholm, Alexander, Shah, Nausheen R., Urban, Federico R.   +6 more
openaire   +2 more sources

Supercooled phase transitions in the very early universe

Physics Letters B, 1982
The universe might have had a prolonged exponentially expanding phase caused by its being stuck in a metastable state of the grand unified phase transition. The only way that it could exit from this exponential expansion without introducing too much inhomogeneity or spatial curvature would be through a homogeneous “bubble” solution in which quantum ...
S.W. Hawking, I.L. Moss
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Bubble nucleation from boson star collapse

Journal of High Energy Physics
We present a new classical mechanism for nucleation of bubbles of true vacuum. The mechanism arises when dense boson stars form in the false vacuum.
Aleksandr Azatov, Takeshi Kobayashi, Nicklas Ramberg   +2 more
doaj   +1 more source