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Phenacetin: an update

Journal of Endodontics, 1979
Phenacetin, or its derivative acetaminophen, is an extremely common and increasingly used substitute for aspirin. Although the drug is mild and effective, its toxicity is less obvious and less manageable than that of aspirin.
G F, Valle   +2 more
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Phenacetin

Drug and Therapeutics Bulletin, 1962
Phenacetin (or acetophenetidin), alone and in combination with other drugs, has been used liberally as an analgesic and antipyretic since its introduction into medical prectice in 1887, and has generally been considered a relatively safe drug (P. K.
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Paracetamol and Phenacetin

Drugs, 1986
Since their synthesis in the late 1800s paracetamol (acetaminophen) and phenacetin have followed divergent pathways with regard to their popularity as mild analgesic/antipyretic drugs. Initially, paracetamol was discarded in favour of phenacetin because the latter drug was supposedly less toxic.
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THE PHENACETIN ENIGMA

Journal of the American Geriatrics Society, 1970
A bstract The unregulated sale of phenacetin‐containing anodynes frequently has led to abuse of this drug by consumers. The demonstration of renal papillary necrosis in persons who habitually use excessive amounts (3.5 kg or more as the cumulative lifetime dose) has been ...
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Phenacetin nephritis

Urology, 1975
Prolonged ingestion of mixed analgesics containing phenacetin has been associated significantly with the development of a chronic interstitial nephritis frequently associated with papillary necrosis. This disease is frequently underdiagnosed. If an adequate history of headache and/or backache (of which most of these patients complain) is not taken, the
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Phenacetin Safety

Science, 1980
A W, Macklin, R M, Welch
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