Results 51 to 60 of about 5,776 (241)

Multistep Reactions Initiated by Amine‐Based Organometallic Methods

open access: yesEuropean Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.
The advent of C–H activation and other organometallic methodologies making use of transient directing groups or free amines themselves for the elaboration of amine substrates provides unique access to cascade‐type reactions that can generate significant molecular complexity in one pot. The pursuit of atom‐ and step‐economical pathways to access complex
Victoria D. Ho   +3 more
wiley   +1 more source

Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones

open access: yesMolecules, 2012
A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]-pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl-aldehydes and enaminones via a two-step synthetic approach.
Jennyfer Iribarra   +5 more
doaj   +1 more source

Tunably strained metallacycles enable modular differentiation of aza-arene C–H bonds

open access: yesNature Communications, 2023
The precise activation of C–H bonds will eventually provide chemists with transformative methods to access complex molecular architectures. Current approaches to selective C–H activation relying on directing groups are effective for the generation of ...
Longlong Xi   +4 more
doaj   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

open access: yesMedicinal Research Reviews, Volume 45, Issue 5, Page 1423-1451, September 2025.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra   +3 more
wiley   +1 more source

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance

open access: yesInternational Journal for Parasitology: Drugs and Drug Resistance, 2019
The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by column chromatography.
Anthonius A. Eze   +4 more
doaj   +1 more source

Interplay of ortho- with spiro-cyclisation during iminyl radical closures onto arenes and heteroarenes

open access: yesBeilstein Journal of Organic Chemistry, 2013
Sensitised photolyses of ethoxycarbonyl oximes of aromatic and heteroaromatic ketones yielded iminyl radicals, which were characterised by EPR spectroscopy.
Roy T. McBurney, John C. Walton
doaj   +1 more source

Electrochemical Hydrogenation of N‐Heterocycles and Related Substrates: A Mini‐Review

open access: yesElectrochemical Science Advances, Volume 5, Issue 4, August 2025.
ABSTRACT Catalytic hydrogenation refers to the (often) metal‐mediated addition of dihydrogen (H2) equivalents to unsaturated compounds to form new element‐hydrogen bonds. This conceptually simple reaction is ubiquitous in the production of a vast number of essential chemicals.
Esteban Garcia‐Torres   +1 more
wiley   +1 more source

A Support Vector Machine Classification Model for Benzo[c]phenathridine Analogues with Topoisomerase-I Inhibitory Activity

open access: yesMolecules, 2012
Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, a support vector machine model was performed on a series of 73 analogues to classify BCP derivatives ...
Thanh-Dao Tran   +4 more
doaj   +1 more source

A ruthenium-catalyzed free amine directed (5+1) annulation of anilines with olefins: diverse synthesis of phenanthridine derivatives.

open access: yesChemical Communications, 2019
A ruthenium(ii)-catalyzed cross-ring (5+1) annulation between 2-aminobiphenyls and activated olefins is disclosed for succinct synthesis of valuable phenanthridine scaffolds.
Deepan Chowdhury   +3 more
semanticscholar   +1 more source

Fluorescent Carbazole‐Derived Aza[5]Helicenes: Synthesis, Functionalization, and Characterization

open access: yesChemistry – A European Journal, Volume 31, Issue 27, May 14, 2025.
Variously substituted indolophenanthridines, indolocarbazoles, and cinnolinocarbazoles synthesized by ortho fusion from teraryl precursors show significant Stokes shifts, especially for the protonated states of indolophenanthridines and cinnolinocarbazole.
Inka Marten   +2 more
wiley   +1 more source

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