Results 1 to 10 of about 10,621 (203)

Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. [PDF]

open access: yesPLoS ONE, 2006
A major goal of drug abuse research is to identify and understand drug-induced changes in brain function that are common to many or all drugs of abuse. As these may underlie drug dependence and addiction, the purpose of the present study was to examine ...
Elin Lehrmann   +8 more
doaj   +2 more sources

Severe tremors induced by tiletamine e-cigarette and alcohol use: a case report [PDF]

open access: yesFrontiers in Psychiatry
Background and objectivesPolydrug use has caused serious harm to public health, especially involving novel psychoactive substances. Tiletamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist commonly used as a veterinary anesthetic, has recently ...
Bojie Zhou   +15 more
doaj   +2 more sources

Comeback of ketamine: resurfacing facts and dispelling myths [PDF]

open access: yesKorean Journal of Anesthesiology, 2021
Initially known as CI-581, ketamine was first synthesized in 1962 as a replacement from phencyclidine. It has since been used as an anesthetic and analgesic.
Abhijit Kumar, Amit Kohli
doaj   +1 more source

A Fatal Case of Late Stage Lyme Borreliosis and Substance Abuse

open access: yesJournal of Affective Disorders Reports, 2023
A recent study demonstrated a 1,100% (12-fold) increase in substance abuse after acquiring Lyme borreliosis. Lyme borreliosis and substance abuse have never been adequately studied and deserves greater attention.
RC Bransfield, ME Embers, AJ Dwork
doaj   +1 more source

Abstract 106: CHANTER Syndrome: A Case Report Of A 59 Year Old Man With Positive Outcome

open access: yesStroke: Vascular and Interventional Neurology, 2023
Introduction Cerebellar, Hippocampal, and Basal Nuclei Transient Edema with Restricted Diffusion (CHANTER) syndrome was first described in 2019 [1] as a pattern of radiographic findings that are distinct from ischemic, anoxic, or toxic brain injury ...
Sherif Elsayed   +3 more
doaj   +1 more source

Neuropsychotoxicity of Abused Drugs: Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects

open access: yesJournal of Pharmacological Sciences, 2008
Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects ...
Eun-Joo Shin   +4 more
doaj   +1 more source

Synthesis and characterization of phencyclidine and his derivatives [PDF]

open access: yesHemijska Industrija, 2010
Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best known representative drug from the compound class of arylcyclohexylamines. On an account of pharmacological activities it belongs to the family of drugs known as a dissociative anesthetics.
Ilić Nataša C.   +3 more
doaj   +1 more source

Current Concepts on Drug Abuse and Dependence [PDF]

open access: yes, 2015
Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza   +5 more
core   +3 more sources

Rapid and Accurate Diagnosis of Substance Abuse: A Narrative Review

open access: yesطب انتظامی, 2023
Introduction One of the major problems in the world is drug abuse [1]. ... [2]. For accurate diagnosis of drug abuse, two important principles are the amount of substance remaining in the body and the time of testing ... [3, 4]. ... [5-10].
Fatemeh Heidarzadeh   +6 more
doaj   +1 more source

Developmental Neurotoxicity of Alcohol and Anesthetic Drugs Is Augmented by Co-Exposure to Caffeine

open access: yesBrain Sciences, 2013
Anesthetic and anti-epileptic drugs used in pediatric and obstetric medicine and several drugs, including alcohol, that are abused by pregnant women, trigger widespread neuroapoptosis in the developing brain of several animal species, including non-human
Catherine E. Creeley   +2 more
doaj   +1 more source

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