Results 21 to 30 of about 10,659 (198)

Discriminative Stimulus Effects of Hallucinogenic Drugs: a Possible Relation to Reinforcing and Aversive Effects

Journal of Pharmacological Sciences, 2012
The subjective effects of drugs are related to the kinds of feelings they produce, such as euphoria or dysphoria. One of the methods that can be used to study these effects is the drug discrimination procedure.
Tomohisa Mori, Kazumi Yoshizawa, Masahiro Shibasaki, Tsutomu Suzuki   +3 more
doaj   +1 more source

The effects of memantine on prepulse inhibition. [PDF]

, 2009
Reduced prepulse inhibition (PPI) of startle provides evidence of deficient sensorimotor gating in several disorders, including schizophrenia. The role of NMDA neurotransmission in the regulation of PPI is unclear, due to cross-species differences in the
Bergsma, F, Swerdlow, NR, Talledo, J, van Bergeijk, DP, Weber, E   +4 more
core   +2 more sources

Ketamine: NMDA receptors and beyond [PDF]

, 2016
Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +2 more sources

Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues.

PLoS ONE, 2016
1,2-Diarylethylamines including lanicemine, lefetamine, and remacemide have clinical relevance in a range of therapeutic areas including pain management, epilepsy, neurodegenerative disease and depression.
Jason Wallach, Heather Kang, Tristan Colestock, Hamilton Morris, Zuner A Bortolotto, Graham L Collingridge, David Lodge, Adam L Halberstadt, Simon D Brandt, Adeboye Adejare   +9 more
doaj   +1 more source

Phencyclidine (PCP) blocks glutamate-activated postsynaptic currents [PDF]

, 1985
Phencyclidine (PCP) was tested on the metathoracic tibialis muscles of Locusta migratoria. In physiological solution, the peak amplitude of the excitatory postsynaptic currents (EPSCs) evoked by nerve stimulation was linearly related to membrane ...
M. Idriss, E.X. Albuquerque, Johnson, Snyder, Vincent, Garey, Marwaha, Albuquerque, Albuquerque, Albuquerque, Corteggiani, Usherwood, Idriss, Idriss, Ishida, Yamamoto, Cull-Candy, Usherwood, Hoyle, Mathers, Takeuchi, Kuba, Gration, Spivak, Andersen, Adler   +25 more
core   +2 more sources

Methods for GC/MS Analysis of the Most Commonly Seized Drugs of Abuse and Their Metabolites in Biological Samples

Chemosensors
Gas chromatography with mass spectrometry (GC-MS) is a common analytical technique used for identifying and quantifying drugs of abuse, as well as their metabolites, extracted from biological samples. Depending on the properties of the analyzed compounds,
Ivan Kojić, Violeta M. Đurović, Yulia A. Smyatskaya, Nemanja Brkljača, Angi E. Skhvediani, Andrey V. Vasin, Ksenija Stojanović, Saša D. Đurović   +7 more
doaj   +1 more source

Substance use in the club scene of Rome : a pilot study [PDF]

, 2014
Date of Acceptance: 28/08/2014 Copyright © 2014 Alessandro Emiliano Vento et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ...
Acciavatti, Tiziano, Bonifaci, Ludovica, Carrus, Dario, Chillemi, Eleonora, Cinosi, Eduardo, Corazza, Ornella, di Giannantonio, Massimo, Lupi, Matteo, Martinotti, Giovanni, Santacroce, Rita, Schifano, Fabrizio, Vento, Alessandro   +11 more
core   +4 more sources

Chemical Straightening as a Source of Analytical Variability in Hair Testing: A Dual‐Analyte Case Report

Drug Testing and Analysis, EarlyView.
ABSTRACT Hair analysis is increasingly used in forensic toxicology; however, result interpretation may be influenced by cosmetic hair treatments. Although the effects of bleaching, dyeing, and thermal straightening have already been evaluated, data on permanent chemical hair straightening are scarce, particularly under in vivo conditions.
Miriam Blanco‐Ces, Ana de‐Castro‐Ríos, María Cobo‐Golpe, Ángela López‐Rabuñal, Angelines Cruz, Elena Lendoiro   +5 more
wiley   +1 more source

Identification of a New Psychoactive Substances of Phencyclidine-type, 2-Oxo-PCPr in Seized e-Cigarette Oil

Zhipu Xuebao
The new psychoactive substances (NPSs) are defined as a category of substances of abuse, either in a pure form or a preparation, that are not listed in the control table by the 1961 Single Convention on Narcotic Drugs or the 1971 Convention on ...
Jia-lei WU, Qiang ZHANG, Xue-hu WANG, Ling-yun LIU, Li-qi CHEN, Rui-hua WANG, Fang-min XU   +6 more
doaj   +1 more source

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self‐Reported Drug Use

Drug Testing and Analysis, EarlyView.
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
A. Y. Simão, T. Rosado, M. Barroso, M. Andraus, E. Gallardo   +4 more
wiley   +1 more source