Results 1 to 10 of about 5,571 (181)

Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse [PDF]

open access: yesPLoS ONE, 2006
A major goal of drug abuse research is to identify and understand drug-induced changes in brain function that are common to many or all drugs of abuse. As these may underlie drug dependence and addiction, the purpose of the present study was to examine ...
Elin Lehrmann   +2 more
exaly   +4 more sources

A Fatal Case of Late Stage Lyme Borreliosis and Substance Abuse

open access: yesJournal of Affective Disorders Reports, 2023
A recent study demonstrated a 1,100% (12-fold) increase in substance abuse after acquiring Lyme borreliosis. Lyme borreliosis and substance abuse have never been adequately studied and deserves greater attention.
RC Bransfield, ME Embers, AJ Dwork
doaj   +2 more sources

Neuropsychotoxicity of Abused Drugs: Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects

open access: yesJournal of Pharmacological Sciences, 2008
Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects ...
Eun-Joo Shin   +4 more
doaj   +2 more sources

Synthesis and characterization of phencyclidine and his derivatives [PDF]

open access: yesHemijska Industrija, 2010
Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best known representative drug from the compound class of arylcyclohexylamines. On an account of pharmacological activities it belongs to the family of drugs known as a dissociative anesthetics.
Ilić Nataša C.   +3 more
doaj   +2 more sources

Severe tremors induced by tiletamine e-cigarette and alcohol use: a case report [PDF]

open access: yesFrontiers in Psychiatry
Background and objectivesPolydrug use has caused serious harm to public health, especially involving novel psychoactive substances. Tiletamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist commonly used as a veterinary anesthetic, has recently ...
Bojie Zhou   +15 more
doaj   +2 more sources

Developmental Neurotoxicity of Alcohol and Anesthetic Drugs Is Augmented by Co-Exposure to Caffeine

open access: yesBrain Sciences, 2013
Anesthetic and anti-epileptic drugs used in pediatric and obstetric medicine and several drugs, including alcohol, that are abused by pregnant women, trigger widespread neuroapoptosis in the developing brain of several animal species, including non-human
Catherine E. Creeley   +2 more
doaj   +3 more sources

Methods for GC/MS Analysis of the Most Commonly Seized Drugs of Abuse and Their Metabolites in Biological Samples

open access: yesChemosensors
Gas chromatography with mass spectrometry (GC-MS) is a common analytical technique used for identifying and quantifying drugs of abuse, as well as their metabolites, extracted from biological samples. Depending on the properties of the analyzed compounds,
Ivan Kojić   +7 more
doaj   +2 more sources

Intracranial Hemorrhage Associated With Phencyclidine Abuse

open access: yesJAMA: The Journal of the American Medical Association, 1982
PHENCYCLIDINE (PCP) is a popular "recreational" drug. Complications of its abuse are myriad and range from mild behavioral disturbances to death. 1-5 Death caused by PCP intoxication is usually due to the "behavioral toxicity" of the drug. 1,2 A case of massive intracranial hemorrhage in a PCP-intoxicated patient is reported herein.
Howard A. Bessen
openaire   +3 more sources

Phencyclidine abuse and depression

open access: yesPsychosomatics, 1983
G, Caracci, P, Migone, S, Mukherjee
openaire   +3 more sources

Comeback of ketamine: resurfacing facts and dispelling myths [PDF]

open access: yesKorean Journal of Anesthesiology, 2021
Initially known as CI-581, ketamine was first synthesized in 1962 as a replacement from phencyclidine. It has since been used as an anesthetic and analgesic.
Abhijit Kumar, Amit Kohli
doaj   +1 more source

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