Results 21 to 30 of about 10,621 (203)

Retraining over the principles and mechanisms involved in the occurrence of false results from urine drug screening tests: Adulteration and strategies to defeat

مجله دانشگاه علوم پزشکی بیرجند, 2022
Screening tests (UDSTs) for the diagnosis of psychoactive drugs can identify drug abuse, improve workplace safety, ensure community health, and play a critical role in therapeutic drug monitoring.
Bamdad Riahi-Zanjani
doaj  

Discriminative Stimulus Effects of Hallucinogenic Drugs: a Possible Relation to Reinforcing and Aversive Effects

Journal of Pharmacological Sciences, 2012
The subjective effects of drugs are related to the kinds of feelings they produce, such as euphoria or dysphoria. One of the methods that can be used to study these effects is the drug discrimination procedure.
Tomohisa Mori, Kazumi Yoshizawa, Masahiro Shibasaki, Tsutomu Suzuki   +3 more
doaj   +1 more source

Phencyclidine (PCP) blocks glutamate-activated postsynaptic currents [PDF]

, 1985
Phencyclidine (PCP) was tested on the metathoracic tibialis muscles of Locusta migratoria. In physiological solution, the peak amplitude of the excitatory postsynaptic currents (EPSCs) evoked by nerve stimulation was linearly related to membrane ...
M. Idriss, E.X. Albuquerque, Johnson, Snyder, Vincent, Garey, Marwaha, Albuquerque, Albuquerque, Albuquerque, Corteggiani, Usherwood, Idriss, Idriss, Ishida, Yamamoto, Cull-Candy, Usherwood, Hoyle, Mathers, Takeuchi, Kuba, Gration, Spivak, Andersen, Adler   +25 more
core   +2 more sources

The role of setting for ketamine abuse: clinical and preclinical evidence [PDF]

, 2012
Drug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug.
Sprenger, Stewart, Tellier, Topp, Triffleman, Vollenweider, Vollenweider, Weir, White   +8 more
core   +1 more source

Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues.

PLoS ONE, 2016
1,2-Diarylethylamines including lanicemine, lefetamine, and remacemide have clinical relevance in a range of therapeutic areas including pain management, epilepsy, neurodegenerative disease and depression.
Jason Wallach, Heather Kang, Tristan Colestock, Hamilton Morris, Zuner A Bortolotto, Graham L Collingridge, David Lodge, Adam L Halberstadt, Simon D Brandt, Adeboye Adejare   +9 more
doaj   +1 more source

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys, A Breier, A Meister, A Meister, AJ Cochilla, AK Malhotra, Aric Madayag, AW MacDonald III, AY Shih, B Moghaddam, B Moghaddam, D Jabaudon, DA Baker, DA Baker, David A Baker, DC Javitt, DD Schoepp, DD Schoepp, DE Featherstone, DM Barch, DP Purohit, DR Weinberger, DS Gupta, DS Lorrain, E Pileblad, ED Luby, F Faltus, F Sams-Dodd, G Hu, G Hu, G Kohr, G Paxinos, GD Pearlson, GJ Marek, H Augustin, H Homayoun, H Sato, H Sies, HB Uylings, HF Bradford, Ilangovan Raju, J Cartmell, J Kilbride, JA Lieberman, James H Meador-Woodruff, JB Manent, JH Cabungcal, JH Krystal, JH Krystal, JM Williamson, JY Kim, K Aoyama, KQ Do, L Lu, Lars V Kristiansen, LE Chavez-Noriega, M D'Ascenzo, M Herrera-Marschitz, M Verhage, ME Jackson, MM Moran, O Valenti, P Steullet, PD Harvey, R Corbett, R Takahata, S Bannai, S Chaki, SA Petersen, SJ Sigrist, SM Deneke, Vahram Haroutunian, W Hauber, W Timmerman, WA Abbott, WE Bunney, Y Huang, ZX Xi, ZX Xi   +78 more
core   +2 more sources

Methods for GC/MS Analysis of the Most Commonly Seized Drugs of Abuse and Their Metabolites in Biological Samples

Chemosensors
Gas chromatography with mass spectrometry (GC-MS) is a common analytical technique used for identifying and quantifying drugs of abuse, as well as their metabolites, extracted from biological samples. Depending on the properties of the analyzed compounds,
Ivan Kojić, Violeta M. Đurović, Yulia A. Smyatskaya, Nemanja Brkljača, Angi E. Skhvediani, Andrey V. Vasin, Ksenija Stojanović, Saša D. Đurović   +7 more
doaj   +1 more source

Analytical evaluation of a rapid on-site oral fluid drug test [PDF]

, 2010
There is a need for a reliable rapid on-site oral fluid test that can be used in police controls to detect impaired drivers. We evaluated the Varian OralabA (R) 6 and collected two oral fluid samples from 250 subjects, one with the Varian OralabA (R) 6 ...
Goessaert, An-Sofie, Pil, Kristof, Veramme, Jolien, Verstraete, Alain   +3 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Identification of a New Psychoactive Substances of Phencyclidine-type, 2-Oxo-PCPr in Seized e-Cigarette Oil

Zhipu Xuebao
The new psychoactive substances (NPSs) are defined as a category of substances of abuse, either in a pure form or a preparation, that are not listed in the control table by the 1961 Single Convention on Narcotic Drugs or the 1971 Convention on ...
Jia-lei WU, Qiang ZHANG, Xue-hu WANG, Ling-yun LIU, Li-qi CHEN, Rui-hua WANG, Fang-min XU   +6 more
doaj   +1 more source