Results 61 to 70 of about 10,621 (203)

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, Volume 4, Issue 1, Page 20-30, March 2026.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

Novel psychoactive substances of interest for psychiatry [PDF]

, 2015
Novel psychoactive substances include synthetic cannabinoids, cathinone derivatives, psychedelic phenethylamines, novel stimulants, synthetic opioids, tryptamine derivatives, phencyclidine-like dissociatives, piperazines, GABA-A/B receptor agonists, a ...
Corkery, John, Orsolini, Laura, Papanti, Duccio, Schifano, Fabrizio   +3 more
core   +1 more source

Impact of a substance use screening program on racial disparities in urine toxicology testing

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Objective To evaluate whether implementing a standardized substance use screening program reduced racial disparities in urine toxicology (Utox) testing among delivery admissions. Methods We conducted a retrospective cohort study of delivery admissions at a single academic center from June 2019 to June 2025. To address known disparities in Utox
Mariam Naqvi, Amin Tavakoli, Camelita S. Thrift, Allison Henry, Jennifer Astasio, Farnaaz Kia, Naomi Greene, Sarah J. Kilpatrick   +7 more
wiley   +1 more source

Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia [PDF]

, 2018
Deficits of brain parvalbumin (PV) are a consistent finding in schizophrenia and models of psychosis. We investigated whether this is associated with abnormal PV gene (PVALB) methylation in the brain in schizophrenia. Bisulfite pyrosequencing was used to
Caroline F Dalton, Gavin P Reynolds, Helene A Fachim, Kinoshita M, Umarat Srisawat   +4 more
core   +1 more source

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat [PDF]

, 1999
The main purpose of this study was to explore the role of the hippocampus in motivated behavior. Rats with bilateral excitotoxic lesions of the hippocampus and controls were trained to lever press for electrical stimulation of the ventral tegmental area.
Altman, Blaha, Brog, Campbell, Carlezon, Cuffel, Devenport, Douglas, Edmonds, Falkai, Fibiger, Fibiger, Fiorino, Fonnum, Fuller, Glickman, Groenewegen, Guy Mittleman, Hawkins, Hodos, Hodos, Jarrard, Jarrard, Kelley, Koob, Koob, Kovelman, Kramarcy, LeDuc, Liebman, Markou, Miliaressis, Mittleman, Olton, Phillips, Phillips, Ranaldi, Schaub, Schmelzeis, Sengstake, Sesack, Siegel, Stephen P. Kelley, Stewart, Sutherland, Taylor, Totterdell, Valenstein, Walass, Whishaw, Wilkinson, Witkin, Yang   +52 more
core   +1 more source

Recent national trends in Salvia divinorum use and substance-use disorders among recent and former Salvia divinorum users compared with nonusers

Substance Abuse and Rehabilitation, 2011
Li-Tzy Wu1, George E Woody2, Chongming Yang3, Jih-Heng Li4, Dan G Blazer11Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA; 2Department of Psychiatry, University of Pennsylvania and Treatment Research ...
Blazer DG, Li JH, Yang C, Woody GE, Wu LT   +4 more
doaj  

Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon [PDF]

, 2019
copyright 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are ...
Catalani, Valeria, Chilcott, Robert, Corazza, Ornella, Corkery, John, Guirguis, Amira, Marrinan, Shanna, Martinotti, Giovanni, Zloh, Mire   +7 more
core   +3 more sources

To use or not to use: an update on licit and illicit ketamine use

Substance Abuse and Rehabilitation, 2011
Jih-Heng Li1, Balasingam Vicknasingam2, Yuet-wah Cheung3, Wang Zhou4, Adhi Wibowo Nurhidayat5, Don C Des Jarlais6, Richard Schottenfeld71College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 2National Centre for Drug Research, Universiti ...
Yuet-wah Cheung, Balasingam Vicknasingam, Jih-Heng Li, et al   +3 more
doaj  

Hallucinogens: mechanisms and medical complications [PDF]

, 2013
Thesis (M.A.)--Boston UniversityHallucinogens are drugs that alter consciousness by distorting primarily auditory and visual perception but they can affect any sensory system. Hallucinogens also affect judgment, orientation, memory, or emotion.
Chan, Ryan Harry Alexander
core   +1 more source

Syntheses, analytical and pharmacological characterizations of the “legal high” 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo) and analogues [PDF]

New psychoactive substances (NPS) are commonly referred to as “research chemicals”, “designer drugs” or “legal highs.” One NPS class is represented by dissociative anesthetics, which include analogues of the arylcyclohexylamine phencyclidine (PCP ...
Aguayo, Aguayo, Ahmadi, Bailey, Bailey, Bradford, Brady, Brandt, Brine, Cheng, Cone, Cone, Elliott, Felsby, Geneste, Gintzler, Helander, Ho, Hugel, Iadarola, Kalir, Katritzky, Lipton, Maddox, Marquis, Martin, McCann, McLaughlin, McMillan, Michely, Morris, Newport, Overton, Parsons, Parsons, Pud, Rammes, Reynolds, Reynolds, Roth, Sang, Su, Su, Thomas, Vaupel, Wallach, Wallach, Wallach, West, Zukin, Zukin   +50 more
core   +1 more source