Results 51 to 60 of about 3,571 (163)
, 2018 International audienceBackground and purpose: Phenelzine is an antidepressant drug known to increase the risk of hypertensive crisis when dietary tyramine is not restricted.
Sophie Le Gonidec +13 more
core +1 more source
Phenelzine: An old drug that may hold clues to the development of new neuroprotective agents
Psychiatry and Clinical Psychopharmacology, 2021 The monoamine oxidase (MAO)-inhibiting antidepressant phenelzine (PLZ) is also used in the treatment of anxiety disorders such as panic disorder and social anxiety disorder and has been shown to have neuroprotective actions in an animal model of ...
Erin M. MacKenzie +5 more
doaj
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.A series of 3‐n‐butylphthalide hydrazine and hydrazide hybrids were synthesized. Among them, NBP‐HY exhibited superior antiplatelet activity compared to both NBP and aspirin. In vivo experiments confirmed that NBP‐HY possesses potent antithrombotic and anti‐ischemic stroke efficacy, coupled with moderate metabolic stability, favorable blood–brain ...
Yong Li +7 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 9, September 2026.ABSTRACT Background Radiotherapy remains a cornerstone of cancer treatment, while its efficacy is often limited by tumor radioresistance and the risk of normal tissue toxicity. Conventional preclinical models, including two‐dimensional (2D) cell cultures and murine xenografts, exhibit significant limitations in recapitulating human tumor ...
Yixian Zhu +4 more
wiley +1 more source
Inhibitory effect of phenelzine on oxidative microsomal enzyme systems of rat liver
, 1983 The inhibitory effects of phenelzine on the hepatic microsomal demethylation of aminopyrine, N,N-dimethylaniline, and p-nitroanisole on the hydroxylation of aniline and on the pharmacokinetics of antipyrine were investigated in the rat.
A. Atitsé-Gbeassor, P. M. Bélanger
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Information &Functional Materials, Volume 3, Issue 3, Page 321-353, September 2026.Luminescent Hydrogen‐bonded organic frameworks (HOFs) provide an innovative platform for sensing and optoelectronic applications. This review outlines design principles, recent advances in synthesis and optical tuning, diverse sensing applications, and discusses current challenges and future directions for HOFs.
Heng Wu +4 more
wiley +1 more source
REVERSİBLE MAO İNHİBİTORS İN THE TREATMENT OF PANİC DISORDERS
Psychiatry and Clinical Psychopharmacology, 2021 Members of three classes of drugs have been shown to have efficacy-tricyclic antidepressants,monoamine oxidase inhibitors and benzodiazepins. Imipramine and clomipramine have been the tricyclic antidepressants most extensively studied.
Nesrin DİLBAZ +3 more
doaj
Journal of Pharmacy & Pharmaceutical Sciences, 2008 PURPOSE. To compare phenelzine (PLZ), an antidepressant drug with anxiolytic properties which inhibits monoamine oxidase (MAO) but also elevates rat brain levels of the amino acids ?-aminobutyric acid (GABA) and alanine (ALA), with vigabatrin (VIG ...
Kathryn G. Todd, Glen B. Baker
doaj +1 more source
From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe +5 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims Sexual function is considered an essential criterion for enhancing the quality of life, encompassing not only the genital component but also mental and physical factors. The present study was conducted to determine the relationship between sexual attitude and sexual function among Iranian women and men during pregnancy ...
Sepideh Mashayekh‐Amiri +3 more
wiley +1 more source