Results 71 to 80 of about 3,571 (163)

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

, 2014
Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme that oxidatively cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 (H3K4Me1, H3K4Me2) and can contribute to gene silencing.
Andrew P. Feinberg (171575), Givens, Jeffrey, Martin S. Taylor (257588), Basso, Manuela, Feinberg, Andrew P., Jay H. Kalin (1310334), Sean D. Taverna (1323702), Ming, Shonoi A., Cole, Philip A., Taylor, Martin S., Avery, Lindsay B., Casero, Robert A., Jianfei Hu (126291), Hsiao, Po-Yuan, Jiang Qian (771), Oliver G. McDonald (1323681), McDonald, Oliver G., Jeffrey Givens (1323696), Heather Roberson (1323678), Lindsay B. Avery (1323708), Tackett, Alan J., Hu, Jianfei, Po-Yuan Hsiao (1310322), Rajiv R. Ratan (46697), Ratan, Rajiv R., Xin Li (51274), Nkosi Adejola (1323684), Taverna, Sean D., Rong Huang (298496), Huang, Rong, Qian, Jiang, Anne M. Cieniewicz (1323705), Shonoi A. Ming (1323693), Cieniewicz, Anne M., Li, Xin, Kalin, Jay H., Prusevich, Polina, Alan J. Tackett (1323690), Philip A. Cole (1310328), Polina Prusevich (1323699), Roberson, Heather, Manuela Basso (256574), Adejola, Nkosi, Robert A. Casero (1323687)   +43 more
core   +1 more source

Assessing Condition‐Specific Adverse Event Profiles of Modafinil for Labelled and Off‐Label Uses: A Systematic Review and Meta‐Analysis

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT Modafinil is approved for excessive daytime sleepiness in narcolepsy, obstructive sleep apnoea (OSA), and shift work sleep disorder (SWSD), but its widespread off‐label use raises safety concerns. We evaluated the risk of adverse events (AEs) associated with both labelled and off‐label use of modafinil.
Jaehee Jung, Jaeyoon Youm, Jihyun Kang, Ah‐Young Kim, Jae Kyung Suh, Hye‐Young Kang   +5 more
wiley   +1 more source

Effect of phenelzine on the metabolism and membranal transport of glucose in brain

, 1971
A colorimetric method for the estimation of phenelzine (β-phenylethylhydrazine) based on its reaction with p-dimethylaminobenzaldehyde is presented. Using this method it was shown that in vivo phenelzine rapidly penetrated all regions of the brain.
Ridge J.W., Stanley H.M.
core   +1 more source

The Antidepressant/Antipanic/Neuroprotective Drug Phenelzine: Neuropharmacological and Drug Metabolism Studies [PDF]

, 2013
Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic and neuroprotective properties. Metabolites of PLZ were investigated in rat brain.
Kumpula, David J
core   +1 more source

Sequential trials of fluoxetine, phenelzine, and tranylcypromine in the treatment of obsessive--compulsive disorder [PDF]

, 1989
The effects of fluoxetine, phenelzine, and tranylcypromine in obsessive-compulsive disorder (OCD) were compared in an open-label pilot study involving sequential treatment with these agents in six patients. Despite full (or maximally tolerated) trials on
Nesse, Randolph M., Modell, Jack G., Schmaltz, Stephen P., Himle, Joseph A., Mountz, James M.   +4 more
core   +1 more source

Phenelzine protects against acetaminophen induced apoptosis in HepG2 cells

Acetaminophen (APAP) overdosing is the most common cause of drug-induced liver failure. Despite extensive study, N-acetylcysteine is currently the only antidote utilized for treatment.
TÜYLÜ KÜÇÜKKILINÇ, ZEKİYE TUBA, ERCAN, AYŞE   +1 more
core   +1 more source

Fluoxetine in Panic Disorder

, 1991
This paper presents the cases of two patients who suffered from panic disorder with agoraphobia and depression. One had been refractory to alprazolam and tricyclics and to behaviour therapy; she had responded to phenelzine, but due to a weight gain of ...
Barry Ledwidge, Carol Solyom, Leslie Solyom   +2 more
core   +1 more source

Lysine-Specific Demethylase 1 Inhibitors: A Comprehensive Review Utilizing Computer-Aided Drug Design Technologies

Molecules
Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising therapeutic target for treating various cancers (such as breast cancer, liver cancer, etc.) and other diseases (blood diseases, cardiovascular diseases, etc.), owing to its observed ...
Di Han, Jiarui Lu, Baoyi Fan, Wenfeng Lu, Yiwei Xue, Meiting Wang, Taigang Liu, Shaoli Cui, Qinghe Gao, Yingchao Duan, Yongtao Xu   +10 more
doaj   +1 more source

Comparative efficacy and acceptability of pharmacological treatments for post-traumatic stress disorder in adults: a network meta-analysis. [PDF]

, 2017
BACKGROUND Guidelines about post-traumatic stress disorder (PTSD) recommend broad categories of drugs, but uncertainty remains about what pharmacological treatment to select among all available compounds.
Stein, Dan J, Salanti, Georgia, Jonathan Ipser, Cowen, Phil J, Geddes, John R, Chaimani, Anna, Williams, Taryn, Cipriani, Andrea, Ipser, Jonathan, John R. Geddes, Adriani Nikolakopoulou, Taryn Williams, Anna Chaimani, Dan J. Stein, Nikolakopoulou, Adriani, Phil J. Cowen, Georgia Salanti, Andrea Cipriani, Chaimani A, Cowen PJ, Geddes JR, Salanti G, Ipser J, Stein DJ, Cipriani A, Williams T, Nikolakopoulou A   +26 more
core   +3 more sources