Results 71 to 80 of about 7,825 (259)
Frontiers in Neuroscience, 2020 Besides several endogenous elements, exogenous factors, including exposure to pesticides, have been recognized as putative factors contributing to the onset and development of neurodegenerative diseases, including Parkinson’s disease (PD).
Thomson Patrick Joseph +7 more
doaj +1 more source
Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis [PDF]
, 2016 S1 IHC in pre-symptomatic and clinical-onset EAE: PV+ cell counts, PNN counts, and Iba-1+ microglia counts. A) Representative fluorescence photomicrographs of PV+ staining (low-mag) in S1 from control (CFA) and EAE animals at the pre-symptomatic stage (7–
Bradley J. Kerr +8 more
core +3 more sources
Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors. [PDF]
, 2022 Monoamine oxidase inhibitors (MAOI) are a class of drugs that were originally developed for the treatment of depression but have since been expanded to be used in management of affective and neurological disorders, as well as stroke and aging-related ...
Burroughs, Caroline R. +8 more
core +3 more sources
Journal of Oral Rehabilitation, Volume 52, Issue 6, Page 923-936, June 2025.ABSTRACT Background Chronic temporomandibular disorder (TMD) pain significantly impairs quality of life and lacks universally effective treatments. Antidepressants, traditionally used for mood disorders, have shown potential in managing chronic pain conditions.
Takara Dei +5 more
wiley +1 more source
Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). [PDF]
PLoS Pathogens, 2011 The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle
Naoki Sakane +10 more
doaj +1 more source
Journal of Neurotrauma, 2017 Lipid peroxidation (LP) is a key contributor to the pathophysiology of traumatic brain injury (TBI). Traditional antioxidant therapies are intended to scavenge the free radicals responsible for either initiation or propagation of LP.
John E. Cebak +4 more
semanticscholar +1 more source
Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 1, March 2025.The case was a 62‐year‐old woman with delusional disorder, somatic type (DDST), presenting with oral somatic delusions. Escitalopram treatment (10 mg/day, increased to 20 mg/day) led to significant symptom improvement, and the symptoms of DDST had nearly resolved approximately 5 weeks after the initiation of escitalopram.
Yunosuke Mizuno +7 more
wiley +1 more source
HIV Medicine, Volume 26, Issue 3, Page 465-478, March 2025.Abstract Introduction Depressive symptoms are highly prevalent among people with HIV, which can negatively impact HIV‐related outcomes. We explore the cascade of mental healthcare for people with HIV experiencing depressive symptoms. Methods People with HIV who were part of the Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY ...
Hajra Okhai +12 more
wiley +1 more source
Acta Pharmaceutica, 2017 γ-Ethyl-γ-phenyl-butyrolactone (EFBL) is a structural combination of the anticonvulsant γ-hydroxy-γ-ethyl-γ-phenylbutyramide (HEPB) and the hypnotic γ-butyrolactone (GBL), which inherits both properties. To clarify its mechanism of action, the effects of
Rasgado Lourdes A. Vega +2 more
doaj +1 more source
Brain and Behavior, Volume 15, Issue 2, February 2025.Hospitalized patients often experience sleep disturbances due to various factors, leading to negative health outcomes. A multi‐faceted approach, including environmental modifications, pharmacological interventions, and non‐pharmacological strategies, can significantly improve sleep quality and patient outcomes.
Ghazal Roostaei +7 more
wiley +1 more source