Results 91 to 100 of about 5,278 (219)

Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma

Haematologica, 2011
Background Isothiocyanates, a family of phytochemicals found in cruciferous vegetables, have cytotoxic effects against several types of tumor cells. Multiple myeloma is a fatal disease characterized by clonal proliferation of plasma cells in the bone ...
Jana Jakubikova, David Cervi, Melissa Ooi, Kihyun Kim, Sabikun Nahar, Steffen Klippel, Dana Cholujova, Merav Leiba, John F. Daley, Jake Delmore, Joseph Negri, Simona Blotta, Douglas W. McMillin, Teru Hideshima, Paul G. Richardson, Jan Sedlak, Kenneth C. Anderson, Constantine S. Mitsiades   +17 more
doaj   +1 more source

Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted N‐Methyl and Nitrile Analogs for Anticancer Therapy

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
By N‐methylation, the intramolecular lactam formation in carborane‐substituted diclofenac analogs is prevented, yielding a series of open‐chain derivatives alongside with their phenyl analogs exhibiting anticancer activity and thus offering a promising avenue for future drug development. This study explores the anticancer potential of N‐methylated open‐
Christoph Selg, Robert Schuster, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Jonas Schädlich, Markus Laube, Jens Pietzsch, Vuk Gordić, Tamara Krajnović, Sanja Mijatović, Danijela Maksimović‐Ivanić, Evamarie Hey‐Hawkins   +12 more
wiley   +1 more source

Methyl jasmonate and 1-methylcyclopropene treatment effects on quinone reductase inducing activity and post-harvest quality of broccoli. [PDF]

PLoS ONE, 2013
Effect of pre-harvest methyl jasmonate (MeJA) and post-harvest 1-methylcyclopropene (1-MCP) treatments on broccoli floret glucosinolate (GS) concentrations and quinone reductase (QR, an in vitro anti-cancer biomarker) inducing activity were evaluated two
Kang Mo Ku, Jeong Hee Choi, Hyoung Seok Kim, Mosbah M Kushad, Elizabeth H Jeffery, John A Juvik   +5 more
doaj   +1 more source

Direct Inhibition of GSDMD by PEITC Reduces Hepatocyte Pyroptosis and Alleviates Acute Liver Injury in Mice

Frontiers in Immunology, 2022
Acute liver injury (ALI), often caused by viruses, alcohol, drugs, etc., is one of the most common clinical liver diseases. Although pyroptosis plays an important role in ALI, there is still a lack of effective clinical drugs related to this mechanism ...
Jie Wang, Ke Shi, Ning An, Shuaifei Li, Mei Bai, Xudong Wu, Yan Shen, Ronghui Du, Jingcai Cheng, Xuefeng Wu, Qiang Xu   +10 more
doaj   +1 more source

Evaluating the Anti‐Oxidant and Anti‐Inflammatory Properties of Watercress Supplementation at Short‐Term Follow‐Up: A Systematic Review of Randomized Controlled Trials

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This systematic review highlights the antioxidant and anti‐inflammatory effects of watercress (WC) supplementation in randomized controlled trials. Despite the heterogeneity in WC formulations, dosage, follow‐up, and outcomes, WC demonstrated improvements in biomarkers such as IL‐1, IL‐6, TNF‐α, and antioxidant enzymes.
Jimmy Wen, Muhammad Karabala, Zohaer Muttalib, Burhaan Syed, Ramy Khalil, Daniel Razick, Adam Razick, David Pai   +7 more
wiley   +1 more source

Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress [PDF]

, 2017
Background: Sulforaphane (SFN), a phytochemical found in abundance in broccoli sprouts, potently induces a variety of antioxidant enzymes, and thereby protects cells from injury induced by various kinds of oxidative stresses.
Yanaka Akinori, 谷中 昭典
core   +2 more sources

Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention [PDF]

The AAPS Journal, 2009
Development of cancer is a long-term and multistep process which comprises initiation, progression, and promotion stages of carcinogenesis. Conceivably, it can be targeted and interrupted along these different stages. In this context, many naturally occurring dietary compounds from our daily consumption of fruits and vegetables have been shown to ...
Ka Lung, Cheung, Ah-Ng, Kong
openaire   +2 more sources

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells [PDF]

, 2014
Benzyl isothiocyanate (BITC), a dietary isothiocyanate derived from cruciferous vegetables, inhibits the proliferation of colorectal cancer cells, most of which overexpress β-catenin as a result of mutations in the genes for adenomatous polyposis coli or
Abe, N, Hou, D-X, Munemasa, S, Murata, Y, Nakamura, Y   +4 more
core   +2 more sources

Thiourea‐Based Compounds Effectiveness Against the Growth of Mycobacterium kansasii: Synthesis, Biological Activity, and Computational Analysis

ChemistrySelect, Volume 10, Issue 16, April 25, 2025.
Fifty thiourea derivatives are synthesized and evaluated against Mycobacterium kansasii. Compounds 2, 47, and 49 demonstrate potent extra‐ and intracellular activity without causing macrophage cytotoxicity, even against the hypervirulent strains. Structure–activity relationships and in silico analyses highlight favorable molecular features and predict ...
Sanderson Dias Calixto, Thatiana Lopes Biá Ventura Simão, Marcos V. Palmeira‐Mello, Gil Mendes Viana, Paloma Wetler Meireles Carreiros Assumpção, Dandara Paiva Barroso de Souza, Camila Couto do Espirito Santo, Vinicius de Oliveira Mussi, Carlos Rangel Rodrigues, Alessandra Mendonça Teles de Souza, Bárbara de A. Abrahim‐Vieira, Lúcio Mendes Cabral, Elena Lasunskaia, Michelle Frazão Muzitano   +13 more
wiley   +1 more source