Results 111 to 120 of about 5,236 (217)

The Role and Applied Value of Mitochondria in Glioma‐Related Research

CNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
ABSTRACT Mitochondria, known as the “energy factory” of cells, are essential organelles with a double membrane structure and genetic material found in most eukaryotic cells. They play a crucial role in tumorigenesis and development, with alterations in mitochondrial structure and function in tumor cells leading to characteristics such as rapid ...
Liwen Chen, Hui Zhang, Chao Shang, Yang Hong   +3 more
wiley   +1 more source

Contradictory Role of Gadd45β in Liver Diseases

Journal of Cellular and Molecular Medicine, Volume 28, Issue 23, December 2024.
ABSTRACT There are three homologous proteins (α, β and γ) in the growth arrest and DNA damage 45 (Gadd45) family. These proteins act as cellular responders to physiological and environmental stimuli. Gadd45β plays a significant role in the pathogenesis of liver diseases. Liver injury and growth stimulation increase expression of Gadd45β, which promotes
Chi Wu, Xiaozhen Song, Miaoxin Zhang, Longjun Yang, Panpan Lu, Qiang Ding, Mei Liu   +6 more
wiley   +1 more source

Covalent Isothiocyanate Inhibitors of Macrophage Migration Inhibitory Factor as Potential Colorectal Cancer Treatments

ChemMedChem, Volume 19, Issue 21, November 4, 2024.
New isothiocyanate inhibitors targeting macrophage migration inhibitory factor (MIF) were synthesized and tested as potential anticancer leads. Lead compounds were screened against the NCI60 cancer cell lines panel and showed reduced growth in colon and renal cancer cell lines.
Lohitha Putha, Liang K. Kok, Matthias Fellner, Malcolm T. Rutledge, Allan B. Gamble, Sigurd M. Wilbanks, Andrea J. Vernall, Joel D. A. Tyndall   +7 more
wiley   +1 more source

Phytochemical Combinations Modulate the Activation of Nrf2 and Expression of SOD in Pancreatic Cancer Cells More Efficiently Than Single Plant Components

Proceedings, 2019
Pancreatic adenocarcinoma mainly occurs in elderly people. Thus, the management of pancreatic cancer in the aging population is becoming increasingly relevant.
Violetta Krajka-Kuźniak, Marta Cykowiak, Wanda Baer-Dubowska   +2 more
doaj   +1 more source

Therapeutic Efficacy of Allyl Isothiocyanate Evaluated on N-Nitrosodiethylamine/Phenobarbitol Induced Hepatocarcinogenesis in Wistar Rats [PDF]

, 2010
N-nitrosodiethylamine (NDEA) is a potential carcinogenic agent that induces liver cancer. To evaluate the chemotherapeutic effect of Allyl isothiocyanate in the experimental model, Wistar male rats were administered single dose of intraperitoneal (IP ...
Gowtham Kumar, A. S., Madhusudhanan, N. (N), Ramakrishnan, V. (V), Selvam, C. A. (C), Thiyagarajan, G. (G)   +4 more
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Regulation of the mammalian heat shock factor 1 [PDF]

, 2017
Living organisms are endowed with the capability to tackle various forms of cellular stress due to the presence of molecular chaperone machinery complexes that are ubiquitous throughout the cell. During conditions of proteotoxic stress, the transcription
Dayalan Naidu, Sharadha, Dinkova-Kostova, Albena T.   +1 more
core   +2 more sources

Microfluidic Interfaces for Chronic Bidirectional Access to the Brain

Advanced Healthcare Materials, Volume 13, Issue 22, September 1, 2024.
The limited passage of molecules between the blood and the brain poses a major challenge for drug research and therapy. To address this, the authors use ultrahigh resolution additive manufacturing to develop a miniaturized microcatheter platform for faster, more predictable, and physiologically nondisruptive fluid delivery as well as reliable fluid ...
Simone Marcigaglia, Robin De Plus, Charysse Vandendriessche, Eleonore Schiltz, Marie‐Lynn Cuypers, Jordi Cools, Luis D. Hoffman, Roosmarijn E. Vandenbroucke, Maarten Dewilde, Sebastian Haesler   +9 more
wiley   +1 more source

Phenethyl isothiocyanate inhibits the carcinogenic properties of hepatocellular carcinoma Huh7.5.1 cells by activating MAPK/PI3K-Akt/p53 signaling pathways [PDF]

PeerJ
Background Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective treatment options. Phenethyl isothiocyanate (PEITC) is a bioactive substance present primarily in the cruciferous vegetables.
Jiao Du, Yuting Zhang, Jiajia Chen, Libo Jin, Liying Pan, Pengyu Lei, Sue Lin   +6 more
doaj   +2 more sources

Cancer prevention by targeting angiogenesis [PDF]

, 2012
Healthy individuals can harbour microscopic tumours and dysplastic foci in different organs in an undetectable and asymptomatic state for many years. These lesions do not progress in the absence of angiogenesis or inflammation.
Albini A, Li V W, Li W W, Noonan D, Tosetti F   +4 more
core   +1 more source

In Vitro and In Vivo Inhibition of Human Bladder Cancer by Broccoli Isothiocyanates: Characterization, Absorption, Metabolism and Interconversion [PDF]

, 2011
Biological Sciences: 1st Place (The Ohio State University Edward F. Hayes Graduate Research Forum)Transitional cell carcinoma of the urinary bladder is the fifth most common neoplasm and the twelfth leading cause of cancer death in the United States.
Abbaoui, Besma
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