Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via Its N-Acetylated Cysteine Conjugated form in Malignant Melanoma [PDF]
AntioxidantsPhenethyl isothiocyanate (PEITC) is a secondary metabolic product yielded upon the hydrolysis of gluconasturtiin and it is highly accumulated in the flowers of watercress.
Sotiris Kyriakou +7 more
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Inhibition of hypoxia inducible factor by phenethyl isothiocyanate [PDF]
Biochemical Pharmacology, 2009 Phenethyl isothiocyanate (PEITC), a natural dietary isothiocyanate, has anti-cancer activity in various in vitro and in vivo models. PEITC inhibits angiogenesis but the molecular mechanisms that underlie this effect are not known. We have now demonstrated that PEITC is an effective inhibitor of hypoxia inducible factor (HIF), a transcription factor ...
Xiuhong Wang +3 more
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Phenethyl Isothiocyanate Inhibits Angiogenesis In vitro and Ex vivo [PDF]
Cancer Research, 2007 Abstract Previous studies, including those from our laboratory, have revealed that phenethyl isothiocyanate (PEITC), a constituent of many edible cruciferous vegetables, not only affords significant protection against chemically induced cancer in animal models but also inhibits growth of cancer cells in culture and in vivo by causing ...
Dong Xiao, Shivendra V. Singh
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A Naturally Derived Watercress Flower-Based Phenethyl Isothiocyanate-Enriched Extract Induces the Activation of Intrinsic Apoptosis via Subcellular Ultrastructural and Ca2+ Efflux Alterations in an In Vitro Model of Human Malignant Melanoma. [PDF]
Nutrients, 2023 Kyriakou S +8 more
europepmc +3 more sources
Phenethyl Isothiocyanate, a Bioactive Agent for Gastrointestinal Health: A Review [PDF]
, 2021 The incidence of gastrointestinal diseases (cancer in particular) has increased progressively with considerable morbidity, mortality, and a high economic impact on the healthcare system. Dietary intake of natural bioactive phytochemicals showed to have cancer-preventing and therapeutic effects.
Ezequiel R. Coscueta +3 more
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Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical. [PDF]
PLoS ONE, 2016 Dietary isothiocyanates abundant as glucosinolate precursors in many edible cruciferous vegetables are effective for prevention of cancer in chemically-induced and transgenic rodent models. Some of these agents, including phenethyl isothiocyanate (PEITC),
Vandana Kumari +5 more
doaj +2 more sources
Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate. [PDF]
Cancer Prev Res (Phila), 2018 Abstract We have shown previously that dietary administration of phenethyl isothiocyanate (PEITC), a small molecule from edible cruciferous vegetables, significantly decreases the incidence of poorly differentiated prostate cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice without any side effects.
Singh KB +5 more
europepmc +4 more sources
DNA methylome, transcriptome, and prostate cancer prevention by phenethyl isothiocyanate in TRAMP mice. [PDF]
Mol Carcinog, 2021 Wu R +9 more
europepmc +3 more sources
Designing of the Anticancer Nanocomposite with Sustained Release Properties by Using Graphene Oxide Nanocarrier with Phenethyl Isothiocyanate as Anticancer Agent [PDF]
Pharmaceutics, 2018 In this study anticancer nanocomposite was designed using graphene oxide (GO) as nanocarrier and Phenethyl isothiocyanate (PEITC) as anticancer agent. The designed formulation was characterized in detailed with XRD, Raman, UV/Vis, FTIR, DLS and TEM etc ...
Dasan Mary Jaya Seema +7 more
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International Journal of Oncology, 2017 Benzyl isothiocyanate (BITC), and phenethyl isothiocyanate (PEITC) have been demonstrated to induce anticancer function in many human cancer cells and also inhibit cancer cell migration and invasion. However, there are no studies that show BITC and PEITC to inhibit cell migration and invasion in mouse melanoma B16F10 cells.
Kuang‐Chi Lai +6 more
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