Results 31 to 40 of about 5,236 (217)
Antioxidants, 2021 Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocyanates, a class of phytochemicals, present in cruciferous ...
Melina Mitsiogianni +7 more
doaj +1 more source
Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate. [PDF]
Cancer Prev Res (Phila), 2018 Abstract We have shown previously that dietary administration of phenethyl isothiocyanate (PEITC), a small molecule from edible cruciferous vegetables, significantly decreases the incidence of poorly differentiated prostate cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice without any side effects.
Singh KB +5 more
europepmc +4 more sources
Antimutagenic Effect of Phenethyl Isothiocyanate [PDF]
Central European Journal of Public Health, 2009 Using the Ames bacterial mutagenicity test, the comet assay, and an in vivo micronucleus test, we investigated the effect of the chemoprotective substance phenethyl isothiocyanate (PEITC) on the mutagenic activity of indirect-acting mutagens and carcinogens aflatoxin B1 (AFB1) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), and direct-acting mutagen ...
Petr, Smerák +4 more
openaire +2 more sources
Effects of 2-Phenethyl Isothiocyanate on Metabolism of 1,3-Butadiene in Smokers. [PDF]
Cancer Prev Res (Phila), 2020 Abstract 2-Phenethyl isothiocyanate (PEITC) is a natural product found as a conjugate in cruciferous vegetables. It has been reported to have preventative properties against lung cancer and to inhibit metabolic activation of tobacco carcinogens.
Boldry EJ +7 more
europepmc +4 more sources
Effect of antioxidants on the genotoxicity of phenethyl isothiocyanate [PDF]
Mutagenesis, 2015 Isothiocyanates are plant-derived compounds that may be beneficial in the prevention of certain chronic diseases. Yet, by stimulating the production of reactive oxygen species (ROS), isothiocyanates can be genotoxic. Whether antioxidants influence isothiocyanate-induced genotoxicity is unclear, but this situation was clarified appreciably herein.
Jared D, Hoffman +2 more
openaire +2 more sources
Myrosinase Compatible Simultaneous Determination of Glucosinolates and Allyl Isothiocyanate by Capillary Electrophoresis Micellar Electrokinetic Chromatography (CE-MEKC) [PDF]
, 2019 Introduction. The functional food Cruciferous vegetables contain glucosinolates which are decomposed by the myrosinase enzyme upon tissue damage. The isothiocyanates are the most frequent decomposition products.
Gonda, Sándor +4 more
core +4 more sources
Türk Biyokimya Dergisi, 2023 The purpose of the study was to prepare an effective and new drug delivery system for enhancing the stability of Phenethyl isothiocyanate (PEITC), and its hepatoprotective effect in the carbon tetrachloride (CCl4)-induced damage in hepatocellular ...
Uyumlu Ayşe Burçin +3 more
doaj +1 more source
Tumor regression by phenethyl isothiocyanate involves DDB2 [PDF]
Cancer Biology & Therapy, 2013 Phenethyl isothiocyanate (PEITC) is a promising cancer chemopreventive agent commonly found in edible cruciferous vegetables. It has been implicated also for therapy, and is in clinical trial for lung cancer. Here, we provide evidence that the tumor suppressive effect of PEITC is related to its ability to induce expression of damaged DNA binding ...
Nilotpal, Roy +4 more
openaire +2 more sources
Pharmaceuticals, 2022 Watercress is an enriched source of phenethyl isothiocyanate (PEITC), among other phytochemicals, with an antioxidant capacity. The aim of this study was to (i) chemically characterize and (ii) biologically evaluate the profile of the main health ...
Sotiris Kyriakou +10 more
doaj +1 more source
Molecules, 2020 Bladder cancer (BC) is a representative of urological cancer with a high recurrence and metastasis potential. Currently, cisplatin-based chemotherapy and immune checkpoint inhibitors are used as standard therapy in patients with advanced/metastatic BC ...
Tomhiro Mastuo +7 more
doaj +1 more source