Results 51 to 60 of about 5,236 (217)
Journal of Ovarian Research, 2012 Background High mortality rates in ovarian cancer are largely a result of resistance to currently used chemotherapies. Expanding therapies with a variety of drugs has the potential to reduce this high mortality rate.
Chan Daniel K, Miskimins W
doaj +1 more source
Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling
Pharmacology Research & Perspectives, 2022 The innate immune system has an emerging role as a mediator of neuro‐immune communication and a therapeutic target for itch. Toll‐like receptor 3 (TLR3) plays an important role in itch, as shown in TLR3 knock‐out mice.
Masaki Moriyama +7 more
doaj +1 more source
Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation [PDF]
, 2018 Watercress is a rich source of phytochemicals with anticancer potential, including phenethyl isothiocyanate (PEITC). We examined the potential for watercress extracts and PEITC to increase the DNA damage caused by ionising radiation (IR) in breast cancer
Commane, Daniel M. +5 more
core +2 more sources
Frontiers in Pharmacology, 2020 Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo ...
Xinhai Jiang +14 more
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Foods, 2021 The aim of this study was to develop inclusions formed by γ-cyclodextrin (γ-CD) and three isothiocyanates (ITCs), including benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and 3-methylthiopropyl isothiocyanate (MTPITC) to improve their ...
Jianan Liu +6 more
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Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms. [PDF]
Biochim Biophys Acta, 2014 The epidemiological evidence suggests a strong inverse relationship between dietary intake of cruciferous vegetables and the incidence of cancer. Among other constituents of cruciferous vegetables, isothiocyanates (ITC) are the main bioactive chemicals present.
Gupta P +3 more
europepmc +4 more sources
Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Glutathione reductase (GR), an essential antioxidant enzyme against oxidative stress, has become an attractive drug target for the development of anticancer and antimalarial drugs.
Xia Li, Maowei Ni, Xiaoling Xu, Wei Chen
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Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models
BMC Medicine, 2012 Background HER2 is an oncogene, expression of which leads to poor prognosis in 30% of breast cancer patients. Although trastuzumab is apparently an effective therapy against HER2-positive tumors, its systemic toxicity and resistance in the majority of ...
Gupta Parul, Srivastava Sanjay K
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Frontiers in Pharmacology, 2023 p53 mutations are prevalent in human cancers; approximately half of patients with esophageal cancer present these mutations. Mutant p53 (mutp53) exerts oncogenic functions that promote malignant tumor progression, invasion, metastasis, and drug ...
Lulu Guan +9 more
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Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases [PDF]
, 2016 Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent
Benjamin, Ivor J +13 more
core +4 more sources