Results 51 to 60 of about 5,278 (219)

Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures

Journal of Ovarian Research, 2012
Background High mortality rates in ovarian cancer are largely a result of resistance to currently used chemotherapies. Expanding therapies with a variety of drugs has the potential to reduce this high mortality rate.
Chan Daniel K, Miskimins W
doaj   +1 more source

Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling

Pharmacology Research & Perspectives, 2022
The innate immune system has an emerging role as a mediator of neuro‐immune communication and a therapeutic target for itch. Toll‐like receptor 3 (TLR3) plays an important role in itch, as shown in TLR3 knock‐out mice.
Masaki Moriyama, Mitsuhiro Konno, Kanako Serizawa, Natsumi Yuzawa, Yuki Majima, Ikuo Hayashi, Tomohiko Suzuki, Mie Kainoh   +7 more
doaj   +1 more source

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation [PDF]

, 2018
Watercress is a rich source of phytochemicals with anticancer potential, including phenethyl isothiocyanate (PEITC). We examined the potential for watercress extracts and PEITC to increase the DNA damage caused by ionising radiation (IR) in breast cancer
Commane, Daniel M., Giallourou, Natasa S., Packham, Graham, Rothwell, Steve D., Rowland, Ian R., Swann, Jonathan R.   +5 more
core   +2 more sources

Nuclear Factor Erythroid 2 Related Factor 2 Activator JC-5411 Inhibits Atherosclerosis Through Suppression of Inflammation and Regulation of Lipid Metabolism

Frontiers in Pharmacology, 2020
Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo ...
Xinhai Jiang, Yining Li, Weizhi Wang, Xiaowan Han, Jiangxue Han, Mingzhu Chen, Jing Zhang, Chenyin Wang, Shunwang Li, Jinque Luo, Xiao Wang, Yang Xu, Yanni Xu, Jingcai Cheng, Shuyi Si   +14 more
doaj   +1 more source

Characterization of the Inclusion Complexes of Isothiocyanates with γ-Cyclodextrin for Improvement of Antibacterial Activities against Staphylococcus aureus

Foods, 2021
The aim of this study was to develop inclusions formed by γ-cyclodextrin (γ-CD) and three isothiocyanates (ITCs), including benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and 3-methylthiopropyl isothiocyanate (MTPITC) to improve their ...
Jianan Liu, Hongyan Wu, Xinying Ao, Hongshun Hao, Jingran Bi, Hongman Hou, Gongliang Zhang   +6 more
doaj   +1 more source

Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Glutathione reductase (GR), an essential antioxidant enzyme against oxidative stress, has become an attractive drug target for the development of anticancer and antimalarial drugs.
Xia Li, Maowei Ni, Xiaoling Xu, Wei Chen
doaj   +1 more source

Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells [PDF]

Molecular Nutrition & Food Research, 2009
AbstractThis study was undertaken to investigate the mechanism by which phenethyl isothiocyanate (PEITC), a natural compound from cruciferous vegetables, exhibits antitumor effect on prostate cancer cells. Cell proliferation, cell cycle, Western blot, gene transfer, and reporter assays were used to test the effects of PEITC on the growth and IL6/JAK ...
Aiyu, Gong, Meilan, He, Donkena, Krishna Vanaja, Ping, Yin, R Jeffrey, Karnes, Charles Y F, Young   +5 more
openaire   +2 more sources

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases [PDF]

, 2016
Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent
Benjamin, Ivor J, Caunt, Christopher J, Chowdhry, Sudhir, Cuenda, Ana, Dayalan Naidu, Sharadha, de la Vega, Laureano, Dinkova-Kostova, Albena T, Hastie, C James, Keyse, Stephen M, Lamont, Douglas J, Risco, Ana, Sutherland, Calum, Torrente, Laura, Zhang, Ying   +13 more
core   +4 more sources

Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth

Frontiers in Pharmacology, 2023
p53 mutations are prevalent in human cancers; approximately half of patients with esophageal cancer present these mutations. Mutant p53 (mutp53) exerts oncogenic functions that promote malignant tumor progression, invasion, metastasis, and drug ...
Lulu Guan, Yalan Yang, Yao Lu, Yu Chen, Xi Luo, Dao Xin, Xiangrui Meng, Zhengzheng Shan, Guozhong Jiang, Feng Wang   +9 more
doaj   +1 more source

Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012
Macrophage migration inhibitory factor is irreversibly inhibited via covalent modification by phenethyl isothiocyanate, a naturally occurring compound with anti-inflammatory and anticancer properties. The structure of the modified protein obtained from X-ray diffraction data to 1.64 Å resolution is presented.
Joel D A, Tyndall, Hongqi, Lue, Malcolm T, Rutledge, Jurgen, Bernhagen, Mark B, Hampton, Sigurd M, Wilbanks   +5 more
openaire   +2 more sources