Results 61 to 70 of about 5,278 (219)

Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models

BMC Medicine, 2012
Background HER2 is an oncogene, expression of which leads to poor prognosis in 30% of breast cancer patients. Although trastuzumab is apparently an effective therapy against HER2-positive tumors, its systemic toxicity and resistance in the majority of ...
Gupta Parul, Srivastava Sanjay K
doaj   +1 more source

Formulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model

Drug Delivery, 2023
Rheumatoid arthritis (RA), a systemic autoimmune disease that dramatically affects patients’ quality of life. Given the intricacy of RA’s pathophysiology, no single treatment can completely halt the disease progression.
Prakash Haloi, B. Siva Lokesh, Saurabh Chawla, V. Badireenath Konkimalla   +3 more
doaj   +1 more source

Effect of antioxidants on the genotoxicity of phenethyl isothiocyanate [PDF]

Mutagenesis, 2015
Isothiocyanates are plant-derived compounds that may be beneficial in the prevention of certain chronic diseases. Yet, by stimulating the production of reactive oxygen species (ROS), isothiocyanates can be genotoxic. Whether antioxidants influence isothiocyanate-induced genotoxicity is unclear, but this situation was clarified appreciably herein.
Jared D, Hoffman, William M, Ward, George, Loo   +2 more
openaire   +2 more sources

MicroRNAs in lung cancer [PDF]

, 2017
Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this ...
An, Baltimore, Belinsky, Brennan, Chen, De Flora, De Flora, Dong, Duan, Gomez, Hao, Harris, Hasegawa, Haugen, Hu, Inoue, Jemal, Jia, Lam, Li, Liu, Nakanishi, Neilson, O'Driscoll, Pan, Peiper, Ren, Schmeck, Schrump, Sensinger, Shah, Slack, Speiser, Stampfli, Wang, Wang, Yoshida, You, Zhang, Zhang, Zienolddiny   +40 more
core   +1 more source

New Mild and Simple Approach to Isothiocyanates: A Class of Potent Anticancer Agents

Molecules, 2017
In our current work, acetyl chloride-mediated synthesis of phenethyl isothiocyanate (PEITC) derivatives proves to be convenient and provides the expected products at good to excellent yields.
Bingling Luo, Jiankang Wang, Xiaobing Li, Wenhua Lu, Jing Yang, Yumin Hu, Peng Huang, Shijun Wen   +7 more
doaj   +1 more source

Targeting crosstalk between Nrf-2, NF-κB and androgen receptor signaling in prostate cancer [PDF]

, 2018
Oxidative stress, inflammation and androgen receptor (AR) signaling play a pivotal role in the initiation, development and progression of prostate cancer (PCa).
Khurana, Namrata, Sikka, Suresh C
core   +2 more sources

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]

, 2020
Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L., Diggins, Eileen, Dinkova-Kostova, Albena, Fahey, Jed W., Liu, Hua, Singh, Kanwaljit, Stephenson, Katherine K., Zimmerman, Andrew W.   +7 more
core   +3 more sources

Role of dietary phytochemicals in modulation of miRNA expression: Natural swords combating breast cancer

Asian Pacific Journal of Tropical Medicine, 2018
The National Cancer Institute had projected breast cancer (BC) as one of the topmost prevalent malignancies around the globe. In many cases, BC becomes resistant to chemotherapy, radiation and hormonal therapies.
Banzeer Ahsan Abbasi, Javed Iqbal, Tariq Mahmood, Ali Talha Khalil, Barkat Ali, Sobia Kanwal, Sayed Afzal Shah, Riaz Ahmad   +7 more
doaj   +1 more source

Allyl isothiocyanate inhibits actin mediated intracellular transport in Arabidopsis thaliana. [PDF]

, 2015
Volatile allyl isothiocyanate (AITC) derives from the biodegradation of the glucosinolate sinigrin and has been associated with growth inhibition in several plants, including the model plant Arabidopsis thaliana.
Bones, Atle M., Sporsheim, Bjørnar, Øverby, Anders   +2 more
core   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source