Results 71 to 80 of about 5,236 (217)

Antibacterial activity and mode of action of selected glucosinolate hydrolysis products against bacterial pathogens [PDF]

, 2015
Plants contain numerous components that are important sources of new bioactive molecules with antimicrobial properties. Isothiocyanates (ITCs) are plant secondary metabolites found in cruciferous vegetables that are arising as promising antimicrobial ...
A Aires, A Aires, A Borges, A Borges, A Borges, A Borges, A Conrad, A Rahman, A Sofrata, A Tabata, AA Al-Gendy, AC Abreu, AC Abreu, AD Russell, AD Russell, B Holst, B Janczuk, B Sun, BA Halkier, BA Halkier, BJ McCabe-Sellers, BK Tiwari, C Ferreira, C Jacob, C Wu, CD Grubb, CF Carson, CJ Oss van, CJ Oss van, CJ Oss van, CM Lin, CM Lin, CM Park, E Hong, EFSA, ES Ahn, F Ahimou, F Mushantaf, FB Luciano, FB Luciano, G Barbieri, G Lerebour, G Tegos, H Chen, H Tajima, HJ Busscher, IS Shin, J Heidler, J Palmer, JL Dangl, JW Fahey, K Cejpek, KH Kyung, L Tang, LF D’Antuono, M Cartea, M Jang, M Oussalah, M Saleem, M Simões, M Simões, M Simões, M Simões, MG Kim, MJ Saavedra, MM Cowan, MP Bos, MS Rhee, MT Black, NG Chorianopoulos, P Gilbert, PA Lambert, PJ Delaquis, PS Negi, R Munday, R Troncoso, RA Dixon, RH Kolm, RN Jones, RP Verma, S Ananou, S Burt, S Langsrud, SD Sarker, SG Gómez De Saravia, SY Wang, T Zsolnai, T-T Liu, V Dufour, Y Diab, Y Zhang, Y-H Pang   +91 more
core   +1 more source

Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate [PDF]

Carcinogenesis, 2006
Prostate cancer usually progresses to androgen refractory after an initial anti-androgen treatment. The androgen receptor (AR) is a pivotal factor for the androgen-mediated growth and maintenance of the prostate. Abnormality of the AR, such as overexpression has been postulated to be related to the hormone independent growth of the cancer.
L G, Wang, X M, Liu, J W, Chiao
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cloning and Characterization of a Biotic-Stress-Inducible Glutathione Transferase from Phaseolus vulgaris [PDF]

, 2013
Glutathione transferases (GSTs, EC 2.5.1.18) are ubiquitous proteins in plants that play important roles in stress tolerance and in the detoxification of toxic chemicals and metabolites.
Chronopoulou, Evangelia, Labrou, Nikolaos E., Madesis, Panagiotis, Tsaftaris, Athanasios   +3 more
core   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, EarlyView.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source

Cholesterol‐Lowering and Radical Scavenging Potential of Fermented Black Kale (Brassica oleracea var. acephala): From Pilot‐Scale Production to in Vivo Study

ChemFoodChem, Volume 1, Issue 2, December 1, 2025.
Abstract Vegetables are rich in bioactive compounds, including fibers and minerals, providing a conspicuous contribution to achieving health benefits. In this study, black kale (Brassica oleracea var. acephala, BK) was fermented using Saccharomyces cerevisiae LI180‐7 strain at pilot scale, producing a safe and consumable product featured by improved ...
Mirco Vacca, Annamaria Tarantini, Mohamad Khalil, Danilo Vona, Francesco M. Calabrese, Giuseppe Celano, Carmen A. Apa, Matteo Bernardi, Leonardo Mancini, Gianni Pietragalla, Laura Mahdi, Domenico Rubino, Matteo Spagnuolo, Gianluca Bleve, Piero Portincasa, Maria De Angelis   +15 more
wiley   +1 more source

Taste and flavour perceptions of glucosinolates, isothiocyanates, and related compounds [PDF]

, 2018
Brassicaceae plants are renowned for their taste, aroma and trigeminal characteristics; predominantly bitter taste, sulfurous aroma and pungency. Compounds responsible for these sensations include the glucosinolates (GSLs) and their hydrolysis products ...
Abe, Agerbirk, Agneta, Agrawal, Baik, Beaver, Behrens, Bell, Bell, Bell, Bell, Bell, Bennett, Bennett, Bonnema, Buck, Cartea, Cerny, Chen, Chin, Chin, Coogan, D'Antuono, D'Auria, Depree, Dinkova-Kostova, Doorn, Drewnowski, Elmore, Elmore, Engel, Fahey, Fenwick, Fenwick, Fowke, Frandsen, Frank, Freeman, Fukuda, Ghawi, Ghawi, Giacoppo, Halkier, Hanschen, Hanschen, Hansen, Hansen, Hasin, Hayes, Hayes, Holst, Hufnagel, Ishida, Jaeger, Jakubikova, Jin, Jirovetz, Jones, Jordt, Kato, Keller, Khataan, Kim, Kirimura, Kubec, Kuchernig, Levine, Lindsay, Ludikhuyze, Matusheski, Matusheski, McRae, Melchini, Mennella, Methven, Meyerhof, Nishimura, Okunade, Padilla, Palaniswamy, Palermo, Park, Parker, Pasini, Pence, Possenti, Prescott, Raffo, Rangkadilok, Reed, Ridgway, Sandell, Sansom, Sarkar, Schonhof, Shapiro, Shen, Siegmund, Steinmetz, Stoewsand, Sultana, Sultana, Suzuki, Swanston, Traka, Traka, Voutsina, Wills, Wold, Wu, Zabaras, Zhao   +111 more
core   +1 more source

Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms

MedComm, Volume 6, Issue 12, December 2025.
Cancer is a complex tumor system consisting of tumor cells, immune effector cells, and all the matrix components. The intricate interactions among cells and molecular signaling pathways in this microenvironment jointly drive tumor growth, invasion, and metastasis, and significantly influence the efficacy of cancer treatment. Meanwhile, the treatment of
Ying Sun, Changjian Shao, Hongtao Duan, Zhaoyang Wang, Shaopeng Xu, Chao Wang, Jiawei Xiu, Jin Liu, Xuejiao Wang, Xin Yao, Yuan Gao, Xiaolong Yan   +11 more
wiley   +1 more source

Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells [PDF]

, 2018
Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites.
Bao, Yongping, Bowater, Richard P, Chen, Yuqiong, Liu, Peng, Smith, Andrew, Wang, Wei, Wormstone, Ian Michael, Zhou, Zhigang   +7 more
core   +3 more sources

Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells [PDF]

Molecular Nutrition & Food Research, 2009
AbstractThis study was undertaken to investigate the mechanism by which phenethyl isothiocyanate (PEITC), a natural compound from cruciferous vegetables, exhibits antitumor effect on prostate cancer cells. Cell proliferation, cell cycle, Western blot, gene transfer, and reporter assays were used to test the effects of PEITC on the growth and IL6/JAK ...
Aiyu, Gong, Meilan, He, Donkena, Krishna Vanaja, Ping, Yin, R Jeffrey, Karnes, Charles Y F, Young   +5 more
openaire   +2 more sources