Results 81 to 90 of about 5,236 (217)

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

In vitro screening of the effect of three glucosinolate derived nitriles on soil-borne fungi [PDF]

, 2006
Glucosinolates are allelochemicals present in all plants of the order Capparales that are hydrolysed by endogenous enzymes (myrosinases) forming a variety of compounds with biological activity.
Bellostas, Natalia, Casanova, Esther, Garcia-Mina, Jose Maria, Sorensen, Hilmer, Sorensen, Jens Christian   +4 more
core  

Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells [PDF]

, 2015
Melanoma cells often express platelet‑activating factor receptor (PAF‑R), which has been demonstrated to increase metastatic behavior. However, the effect of PAF‑R on the responsiveness of melanoma to naturally occurring cytotoxic agents remains to be ...
Sahu, Ravi Prakash
core   +1 more source

Aromatic Volatile Compounds of Essential Oils: Distribution, Chemical Perspective, Biological Activity, and Clinical Applications

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
The review explores the origins, chemical structures, and bioactivities of aromatic volatile compounds in essential oils from various plants. It highlights their therapeutic uses in treating disorders like infections and IBS, as well as their applications in food, cosmetics, and pharmaceuticals.
Hamdoon A. Mohammed, Ghassan M. Sulaiman, Ali Z. Al‐Saffar, Mayyadah H. Mohsin, Riaz A. Khan, Noora A. Hadi, Shahad Basil Ismael, Fatma Elshibani, Ahmed Ismail, Mosleh M. Abomughaid   +9 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. [PDF]

AAPS J, 2014
Phenethyl isothiocyanate (PEITC)-a naturally occurring isothiocyanate in cruciferous vegetables-has been extensively studied as a chemopreventive agent in several preclinical species and in humans. Pharmacokinetic features of unchanged PEITC are (I) linear and first-order absorption, (II) high protein binding and capacity-limited tissue distribution ...
Morris ME, Dave RA.
europepmc   +4 more sources

Differential induction of apaptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent

, 2012
Phenethyl isothiocyanate (PEITC) is a naturally occurring electrophile which depletes intracellular glutathione (GSH) levels and triggers accumulation of reactive oxygen species (ROS).
Cavell, Breeze E., Donlevy, Alison, Packham, Graham, Syed Alwi, Sharifah S.   +3 more
core   +1 more source

The action of selected isothiocyanates on bacterial biofilm prevention and control [PDF]

, 2014
The activity of two selected isothiocyanates (ITCs), allylisothiocyanate (AITC) and 2-phenylethy-lisothiocyanate (PEITC) was evaluated on the prevention and control of biofilms formed by Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and
Abreu, Aires, Aires, Al-Gendy, Al-Sohaibani, An, Anabela Borges, Anderson, Andersson, Andersson, Aslam, Barbieri, Berhow, Borges, Brown, Busscher, Butler, Cartea, Cejpek, Chen, Chen, Clarke, Conaway, Cos, D'Antuono, Dalton, De Saravia, Delaquis, Donlan, Déziel, EFSA, Fahey, Fahey, Ferreira, Gilbert, Gilbert, Gray, Grubb, Gründling, Guiamet, Guillemot, Gómez De Saravia, Gómez-Gómez, Halkier, Halkier, Hall-Stoodley, Harshey, Henrichsen, Holst, Hong, Inoue, Jacob, Jagani, Janczuk, Jang, Jarrell, Jiang, Julkowska, Kaito, Kearns, Kim, Kolm, Lai, Lee, Lin, Lin, Luciano, Lúcia C. Simões, Machado, Mah, Manuel Simões, Maria J. Saavedra, Masuda, Monroe, Munday, Newman, O'Toole, Overhage, Pettit, Prior, Rashid, Rhee, Roberts, Saavedra, Sandasi, Sarker, Shin, Shrout, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Sofrata, Stepanović, Stewart, Stickland, Tegos, Toté, Troncoso, Tsompanidou, Van Oss, Van Oss, Van Oss, Verma, Walsh, Zhang, Zou   +114 more
core   +1 more source

Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012
Macrophage migration inhibitory factor is irreversibly inhibited via covalent modification by phenethyl isothiocyanate, a naturally occurring compound with anti-inflammatory and anticancer properties. The structure of the modified protein obtained from X-ray diffraction data to 1.64 Å resolution is presented.
Joel D A, Tyndall, Hongqi, Lue, Malcolm T, Rutledge, Jurgen, Bernhagen, Mark B, Hampton, Sigurd M, Wilbanks   +5 more
openaire   +2 more sources

Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted N‐Methyl and Nitrile Analogs for Anticancer Therapy

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
By N‐methylation, the intramolecular lactam formation in carborane‐substituted diclofenac analogs is prevented, yielding a series of open‐chain derivatives alongside with their phenyl analogs exhibiting anticancer activity and thus offering a promising avenue for future drug development. This study explores the anticancer potential of N‐methylated open‐
Christoph Selg, Robert Schuster, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Jonas Schädlich, Markus Laube, Jens Pietzsch, Vuk Gordić, Tamara Krajnović, Sanja Mijatović, Danijela Maksimović‐Ivanić, Evamarie Hey‐Hawkins   +12 more
wiley   +1 more source

Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli

Signal Transduction and Targeted Therapy, 2021
Previous studies demonstrated that superoxide could initiate and amplify LDH-catalyzed hydrogen peroxide production in aqueous phase, but its physiological relevance is unknown. Here we showed that LDHA and LDHB both exhibited hydrogen peroxide-producing
Hao Wu, Yuqi Wang, Minfeng Ying, Chengmeng Jin, Jiangtao Li, Xun Hu   +5 more
doaj   +1 more source