Results 81 to 90 of about 5,278 (219)

In vitro screening of the effect of three glucosinolate derived nitriles on soil-borne fungi [PDF]

, 2006
Glucosinolates are allelochemicals present in all plants of the order Capparales that are hydrolysed by endogenous enzymes (myrosinases) forming a variety of compounds with biological activity.
Bellostas, Natalia, Casanova, Esther, Garcia-Mina, Jose Maria, Sorensen, Hilmer, Sorensen, Jens Christian   +4 more
core  

Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells [PDF]

, 2015
Melanoma cells often express platelet‑activating factor receptor (PAF‑R), which has been demonstrated to increase metastatic behavior. However, the effect of PAF‑R on the responsiveness of melanoma to naturally occurring cytotoxic agents remains to be ...
Sahu, Ravi Prakash
core   +1 more source

Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms

MedComm, Volume 6, Issue 12, December 2025.
Cancer is a complex tumor system consisting of tumor cells, immune effector cells, and all the matrix components. The intricate interactions among cells and molecular signaling pathways in this microenvironment jointly drive tumor growth, invasion, and metastasis, and significantly influence the efficacy of cancer treatment. Meanwhile, the treatment of
Ying Sun, Changjian Shao, Hongtao Duan, Zhaoyang Wang, Shaopeng Xu, Chao Wang, Jiawei Xiu, Jin Liu, Xuejiao Wang, Xin Yao, Yuan Gao, Xiaolong Yan   +11 more
wiley   +1 more source

Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells [PDF]

, 2018
Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites.
Bao, Yongping, Bowater, Richard P, Chen, Yuqiong, Liu, Peng, Smith, Andrew, Wang, Wei, Wormstone, Ian Michael, Zhou, Zhigang   +7 more
core   +3 more sources

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Differential induction of apaptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent

, 2012
Phenethyl isothiocyanate (PEITC) is a naturally occurring electrophile which depletes intracellular glutathione (GSH) levels and triggers accumulation of reactive oxygen species (ROS).
Cavell, Breeze E., Donlevy, Alison, Packham, Graham, Syed Alwi, Sharifah S.   +3 more
core   +1 more source

The action of selected isothiocyanates on bacterial biofilm prevention and control [PDF]

, 2014
The activity of two selected isothiocyanates (ITCs), allylisothiocyanate (AITC) and 2-phenylethy-lisothiocyanate (PEITC) was evaluated on the prevention and control of biofilms formed by Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and
Abreu, Aires, Aires, Al-Gendy, Al-Sohaibani, An, Anabela Borges, Anderson, Andersson, Andersson, Aslam, Barbieri, Berhow, Borges, Brown, Busscher, Butler, Cartea, Cejpek, Chen, Chen, Clarke, Conaway, Cos, D'Antuono, Dalton, De Saravia, Delaquis, Donlan, Déziel, EFSA, Fahey, Fahey, Ferreira, Gilbert, Gilbert, Gray, Grubb, Gründling, Guiamet, Guillemot, Gómez De Saravia, Gómez-Gómez, Halkier, Halkier, Hall-Stoodley, Harshey, Henrichsen, Holst, Hong, Inoue, Jacob, Jagani, Janczuk, Jang, Jarrell, Jiang, Julkowska, Kaito, Kearns, Kim, Kolm, Lai, Lee, Lin, Lin, Luciano, Lúcia C. Simões, Machado, Mah, Manuel Simões, Maria J. Saavedra, Masuda, Monroe, Munday, Newman, O'Toole, Overhage, Pettit, Prior, Rashid, Rhee, Roberts, Saavedra, Sandasi, Sarker, Shin, Shrout, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Simões, Sofrata, Stepanović, Stewart, Stickland, Tegos, Toté, Troncoso, Tsompanidou, Van Oss, Van Oss, Van Oss, Verma, Walsh, Zhang, Zou   +114 more
core   +1 more source

Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli

Signal Transduction and Targeted Therapy, 2021
Previous studies demonstrated that superoxide could initiate and amplify LDH-catalyzed hydrogen peroxide production in aqueous phase, but its physiological relevance is unknown. Here we showed that LDHA and LDHB both exhibited hydrogen peroxide-producing
Hao Wu, Yuqi Wang, Minfeng Ying, Chengmeng Jin, Jiangtao Li, Xun Hu   +5 more
doaj   +1 more source

Myricetin as a Potential Adjuvant in Chemotherapy: Studies on the Inhibition of Human Glutathione Transferase A1–1

Biomolecules, 2022
Glutathione transferases (GSTs) are a family of Phase II detoxification enzymes that are involved in the development of multi-drug resistance (MDR) phenomena toward chemotherapeutic agents.
Mohammed Hamed Alqarni, Ahmed Ibrahim Foudah, Magdy Mohamed Muharram, Aftab Alam, Nikolaos E. Labrou   +4 more
doaj   +1 more source

Aromatic Volatile Compounds of Essential Oils: Distribution, Chemical Perspective, Biological Activity, and Clinical Applications

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
The review explores the origins, chemical structures, and bioactivities of aromatic volatile compounds in essential oils from various plants. It highlights their therapeutic uses in treating disorders like infections and IBS, as well as their applications in food, cosmetics, and pharmaceuticals.
Hamdoon A. Mohammed, Ghassan M. Sulaiman, Ali Z. Al‐Saffar, Mayyadah H. Mohsin, Riaz A. Khan, Noora A. Hadi, Shahad Basil Ismael, Fatma Elshibani, Ahmed Ismail, Mosleh M. Abomughaid   +9 more
wiley   +1 more source