Results 141 to 150 of about 3,784 (223)

The Importance of Phenoconversion when using the CYP2D6 Genotype in Clinical Practice

, 2022
Emily J. Cicali, Kristin Wiisanen
openalex   +2 more sources

Illustrative and historic cases of phenoconversion.

American journal of translational research
Intersubject variability in drug response, whether related to efficacy or toxicity, is well recognized clinically. Over the years, drug selection from our pharmacologic armamentarium has moved from providers' preferred choices to more personalized treatments as clinicians' decisions are guided by data from clinical trials.
Veronique, Michaud, Pamela, Dow, Jacques, Turgeon   +2 more
openaire   +1 more source

The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Aging, 2016
Idiopathic pulmonary fibrosis (IPF) is an age-related multifactorial disease featuring non-uniform lung fibrosis. The decisive cellular events at early stages of IPF are poorly understood. While the involvement of club cells in IPF pathogenesis is unclear, their migration has been associated with lung fibrosis.
Fukumoto, Jutaro, Soundararajan, Ramani, Leung, Joseph, Cox, Ruan, Jr., Mahendrasah, Sanjay, Muthavarapu, Neha, Herrin, Travis, Czachor, Alexander, Tan, Lee C., Hosseinian, Nima, Patel, Priyanshi, Gone, Jayanthraj, Breitzig, Mason T., Cho, Young, Cooke, Andrew J., Galam, Lakshmi, Narala, Venkata Ramireddy, Pathak, Yashwant, Lockey, Richard F., Kolliputi, Narasaiah   +19 more
openaire   +3 more sources

Insular monoaminergic deficits in prodromal α‐synucleinopathies

Annals of Clinical and Translational Neurology
Methods This study assessed data from two cohorts of patients with alpha‐synucleinopathies (University of Brescia and University of Rome Tor‐Vergata cohorts).
Andrea Pilotto, Alice Galli, Cinzia Zatti, Fabio Placidi, Francesca Izzi, Enrico Premi, Silvia P. Caminiti, Luca Presotto, Andrea Rizzardi, Marcello Catania, Alessandro Lupini, Leandro Purin, Maria P. Pasolini, Nicola B. Mercuri, Agostino Chiaravalotti, Mariana Fernandes, Carmen Calvello, Silvia Lucchini, Francesco Bertagna, Barbara Paghera, Daniela Perani, Daniela Berg, Alessandro Padovani, Claudio Liguori   +23 more
doaj   +1 more source

Blunted tachycardia and cardiac sympathetic denervation in isolated rapid eye movement sleep behavior disorder

BMC Neurology
Background Isolated rapid eye movement sleep behavior disorder (iRBD) serves as a prodromal phase of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).
Shota Saeda, Yukiyoshi Sumi, Koichi Fujiwara, Hiroshi Kadotani   +3 more
doaj   +1 more source

TREK-1 knock-down in human atrial fibroblasts leads to a myofibroblastic phenotype: a role in phenoconversion and over-view of mechano-sensitive channel mRNA expression in cardiac diseases [PDF]

, 2022
Elisa Darkow, Dilmurat Yusuf, Sridharan Rajamani, Rolf Backofen, Peter Köhl, Ursula Ravens, Rémi Peyronnet   +6 more
openalex   +1 more source

The utility of neuro-QOL in idiopathic REM sleep behavior disorder

Sleep Science and Practice
Introduction Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) can affect quality of life (QOL) for both patient and bed partner; has been less well-studied.
Daniel A. Barone, Harini Sarva, Natalie Hellmers, Fei Wang, Zhenxing Xu, Ana C. Krieger, Claire Henchcliffe   +6 more
doaj   +1 more source

Phenoconversion of CYP2C9 in epilepsy limits the predictive value of CYP2C9 genotype in optimizing valproate therapy [PDF]

, 2015
Bűdi, Tamás, Háfra, Edit, Kiss, Ádám, Monostory, Katalin, Temesvári, Manna, Tóth, Katalin   +5 more
core   +1 more source

Editorial: Prodromal stage of neurodegenerative proteinopathies: from bench to bedside

Frontiers in Neuroscience, 2023
Bin Xu, Bin Xu, Seyed-Mohammad Fereshtehnejad, Seyed-Mohammad Fereshtehnejad, Yashar Zeighami, Yashar Zeighami   +5 more
doaj   +1 more source

Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities

npj Parkinson's Disease
Parkinson’s disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years.
Mathangi Palanivel, Krishna Kanta Ghosh, Madhav Mallam, Raghavan Bhuvanakantham, Parasuraman Padmanabhan, Kah-Leong Lim, Balázs Gulyás   +6 more
doaj   +1 more source