Results 111 to 120 of about 41,824,283 (165)

Large-scale cross-trait genetic analysis highlights shared genetic backgrounds of autoimmune diseases

Immunological Medicine
Disorders associated with the immune system burden multiple organs, although the shared biology exists across the diseases. Preceding family-based studies reveal that immune diseases are heritable to varying degrees, providing the basis for ...
Yuji Yamamoto, Yuya Shirai, Ryuya Edahiro, Atsushi Kumanogoh, Yukinori Okada   +4 more
doaj   +1 more source

From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases

Clinical Cardiology, Volume 49, Issue 10, October 2026.
Genomic medicine in cardiovascular care is progressing from established diagnostic applications toward integrated risk prediction, multiomics, and emerging therapeutic strategies. ABSTRACT Background Genomic cardiology is an emerging field integrating genetic, molecular, imaging, and digital health data to improve cardiovascular disease (CVD ...
Neda Mohsen‐Pour, Shiva Esmaeili, Aydin Feyzi, Ali Sharafi, Majid Maleki, Samira Kalayinia   +5 more
wiley   +1 more source

The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank

Human Genomics
Background Disease comorbidities and longer-term complications, arising from biologically related associations across phenotypes, can lead to increased risk of severe health outcomes.
Vivek Sriram, Jakob Woerner, Yong-Yeol Ahn, Dokyoon Kim   +3 more
doaj   +1 more source

PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses

Frontiers in Pharmacology
IntroductionBasal cell carcinoma (BCC) is the most common skin cancer, lacking reliable biomarkers or therapeutic targets for effective treatment. Genome-wide association studies (GWAS) can aid in identifying drug targets, repurposing existing drugs ...
Qiu-Ju Han, Yi-Pan Zhu, Jing Sun, Xin-Yu Ding, Xiuyu Wang, Qiang-Zhe Zhang   +5 more
doaj   +1 more source

Integrated Single‐Myofibre Multi‐Omics Correlates Inflammatory State to Myosin Energetics in ICU‐Acquired Weakness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Skeletal muscle atrophy is a pervasive complication of critical illness that worsens survival and recovery, yet remains poorly explained by current clinical or molecular markers. Methods To directly connect disease‐associated molecular states to the contractile machinery, this study combined sequential functional, transcriptomic and
Alexandra M. Winant, Roger Moreno‐Justicia, Lucia Paolini, Wout J. Claassen, Coen A. C. Ottenheijm, Atul S. Deshmukh, Stefano Cattaneo, Simone Piva, Nicola Latronico, Robert A. E. Seaborne, Julien Ochala   +10 more
wiley   +1 more source

Clinical and genetic associations for night eating syndrome in a patient biobank

Journal of Eating Disorders
Objective Night eating syndrome (NES) is an eating disorder characterized by evening hyperphagia. Despite having a prevalence comparable to some other eating disorders, NES remains sparsely investigated and poorly characterized.
Hannah Wilcox, Richa Saxena, John W. Winkelman, Hassan S. Dashti   +3 more
doaj   +1 more source

PSEN1 Expression Identifies a Developmentally Distinct Favourable‐Prognosis State in SHH α Medulloblastoma

International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.
High PSEN1 expression identifies a favourable‐prognosis state in SHH α medulloblastoma and is associated with a reproducible transcriptional programme related to cellular homeostasis and development. Its broad expression during cerebellar development and across paediatric brain tumours suggests that its prognostic significance reflects the specific ...
Julia Vanini, Amanda Thomaz, Marina Müller Lupatini, André T. Brunetto, Caroline Brunetto de Farias, Mariane Jaeger, Rafael Roesler   +6 more
wiley   +1 more source

Genome‐Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID‐19

Influenza and Other Respiratory Viruses, Volume 20, Issue 10, October 2026.
ABSTRACT Background Influenza remains a significant global health burden, potentially leading to hospitalization and mortality. Although previous studies have explored genetic susceptibility to influenza infection, the genetic basis of influenza hospitalization and its relationship with respiratory diseases like COVID‐19 remain poorly understood ...
Xiao Xue, Yaning Feng, Yu‐Ping Lin, Pui‐Ching Chan, Hon‐Cheong So   +4 more
wiley   +1 more source

Cell‐based crop phenotyping for future climates

New Phytologist, Volume 252, Issue 2, Page 575-587, October 2026.
Flow‐chart diagram illustrating the proposed pathway for improving the throughput of fluorescence imaging‐based phenotyping by using robotics and machine learning (ML) approaches. Summary Abiotic stress tolerance has been significantly weakened in modern crops during the domestication process.
Sergey Shabala, Ping Yun, Zhong‐Hua Chen, Meixue Zhou, Min Yu, Nadia Bazihizina   +5 more
wiley   +1 more source

Spatial Transcriptomic and Proteomic Analysis Identifies Novel Immune‐Associated Biomarkers of Anti‐PD1 Response in Metastatic Melanoma

Scandinavian Journal of Immunology, Volume 104, Issue 4, October 2026.
Integrated anti‐PD1 transcriptomic datasets identified poor survival predictor biomarkers associated with therapy resistance in metastatic melanoma. Spatial transcriptomic and proteomic profiling revealed FAM57A, GSTA4, and KCTD1 as immune‐associated biomarkers linked to altered immune transcriptomic signatures, increased PI3K‐AKT‐mTORC1/MAPK proteomic
S. A. Koskela, R. E. Kallionpää, I. Mäkelä, E.‐M. Birkman, M. Sundvall, C. R. Figueiredo   +5 more
wiley   +1 more source