Results 81 to 90 of about 41,824,283 (165)

Impacts of leukocyte telomere length on incidence and severity of age-related cataract: a cross-cohort analysis

Eye and Vision
Objective To investigate the relationship between leukocyte telomere length (LTL), a biomarker of cellular aging, and both the incidence and severity of age-related cataract (ARC) across cohorts from the UK and China. Methods The multicenter, multiethnic
Xianqi Zheng, Ting Su, Chenxiao Shen, Guanrong Wu, Zijing Du, Xingchen Geng, Yuling Xu, Ningni Jiang, Qinyi Li, Jiahui Cao, Ying Fang, Yijun Hu, Mingguang He, Zhuoting Zhu, Xiayin Zhang, Honghua Yu   +15 more
doaj   +1 more source

Refining Genetic Instruments for Dietary Intake Mendelian Randomization Using Phenome‐Wide Association Studies

Genetic Epidemiology, Volume 50, Issue 8, December 2026.
ABSTRACT Most Mendelian randomization (MR) of dietary intake use the full set of genome‐wide significant (GWS) variants in the instrumental variable (IV), likely biasing causal estimates due to pleiotropy. To characterize the common methods to handle pleiotropy in dietary intake MR, we conducted a scoping review of the literature on dietary intake MR ...
Kristen J. Sutton, Julie E. Gervis, Moomal Jatoi, Liang‐Dar Hwang, Audrey E. Hendricks, Debashis Ghosh, Kenneth E. Westerman, Joanne B. Cole   +7 more
wiley   +1 more source

A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine

, 2021
Background: We performed a phenome-wide association study to identify pre-existing conditions related to Coronavirus disease 2019 (COVID-19) prognosis across the medical phenome and how they vary by race.
Bhramar Mukherjee, Maxwell Salvatore, Lars G. Fritsche, Karandeep Singh, Snehal Patil, Lynda Lisabeth, Brahmajee K. Nallamothu, Sachin Kheterpal, Swaraaj Prabhu Sankar, Jasmine A. Mack, Tian Gu, Thomas S. Valley   +11 more
core   +1 more source

Multi‐Trait GWAS Analyses of Blood Pressure Traits Provide Limited Gains in Locus Discovery or Polygenic Risk Score Performance Compared to Single‐Trait GWAS

Genetic Epidemiology, Volume 50, Issue 8, December 2026.
ABSTRACT High blood pressure (BP) represents a major cause of life‐threatening cardiovascular conditions. GWAS have identified >2000 BP‐associated signals. BP‐GWAS usually analyze each BP trait individually. However, multi‐trait GWAS may yield novel loci and improve polygenic risk scores (PRS) prediction. We explored whether multi‐trait BP‐GWAS can: (i)
Yujia Ma, Anna D. Argoty‐Pantoja, Tian Xie, Michael R. Barnes, Patricia B. Munroe, Claudia P. Cabrera, Harold Snieder, Helen R. Warren, UMCG Genetics Lifelines Initiative (UGLI) group author: LifeLines Cohort Study, Raul Aguirre‐Gamboa, Patrick Deelen, Lude Franke, Jan A. Kuivenhoven, Esteban A. Lopera Maya, Ilja M. Nolte, Serena Sanna, Harold Snieder, Morris A. Swertz, Peter M. Visscher, Judith M. Vonk, Cisca Wijmenga, Naomi Wray   +21 more
wiley   +1 more source

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

eLife, 2019
The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores (PRS). In this study, we have analysed 162 PRS (p<5×10−05)
Tom G Richardson, Sean Harrison, Gibran Hemani, George Davey Smith   +3 more
doaj   +1 more source

Root trait dynamics of historical canola varieties under low and high nitrogen supply

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Nitrogen fertilizer is a major input cost in crop production, making it crucial to enhance nitrogen use efficiency (NUE) to reduce fertilizer dependence without compromising yields. Root system architecture (RSA) is a key determinant of nutrient acquisition, particularly under nutrient‐limited conditions.
Shankar Pahari, Raju Soolanayakanahally
wiley   +1 more source

CoPheScan: phenome-wide association studies accounting for linkage disequilibrium. [PDF]

Phenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants which impact a specific protein, this can help identify additional therapeutic indications or on ...

core   +4 more sources

Affordable Phenomics special topic—Foreword for The Plant Phenome Journal

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract The Affordable Phenomics special topic in The Plant Phenome Journal showcased recent advances that expand the accessibility, cost‐effectiveness, and scalability of plant phenotyping technologies. This collection of 15 articles presented innovative approaches, ranging from low‐cost sensors and open‐source analytical pipelines to artificial ...
Valerio Hoyos‐Villegas, Michael A. Gore   +1 more
wiley   +1 more source

A Phenome-Wide Mendelian Randomization and Colocalization Study Reveals Genetic Association Between PBC and Other Autoimmune Disorders

Canadian Journal of Gastroenterology and Hepatology
Conclusions: Our study revealed genetic association between PBC and hypothyroidism through a phenome-wide Mendelian randomization, and then, colocalization identified two potential drug targets for hypothyroidism.
Shuyi Shi, Minghui Liu, Haonan Gao, Fang Liu, Yuhu Song   +4 more
doaj   +1 more source

Proteome-wide Mendelian randomization identifies therapeutic targets for ankylosing spondylitis

Frontiers in Immunology
BackgroundAnkylosing Spondylitis (AS) is a chronic inflammatory disorder which can lead to considerable pain and disability. Mendelian randomization (MR) has been extensively applied for repurposing licensed drugs and uncovering new therapeutic targets ...
Wenlong Zhao, Wenlong Zhao, Peng Fang, Chengteng Lai, Xiaoyu Xu, Yang Wang, Hao Liu, Hui Jiang, Xiaozhou Liu, Jun Liu   +9 more
doaj   +1 more source