Results 101 to 110 of about 27,998 (235)

Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis

Cellular & Molecular Biology Letters
Background Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes.
Chenxi Xiao, Zhenghua Su, Jialin Zhao, Subei Tan, Mengting He, Yuhui Li, Jiayao Liu, Jie Xu, Yajie Hu, Zhongzheng Li, Chunxiang Fan, Xinhua Liu   +11 more
doaj   +1 more source

Network-based Phenome-Genome Association Prediction by Bi-Random Walk. [PDF]

, 2015
The availability of ontologies and systematic documentations of phenotypes and their genetic associations has enabled large-scale network-based global analyses of the association between the complete collection of phenotypes (phenome) and genes.
YaoGong Zhang, Rui Kuang (74290), Rui Kuang, YingJie Xu (733361), YaoGong Zhang (733362), TaeHyun Hwang, MaoQiang Xie, YingJie Xu, MaoQiang Xie (733360), TaeHyun Hwang (733363)   +9 more
core   +1 more source

Genome–phenome association prediction using weighted deep matrix factorization with a multisource graph attention network

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Genome–phenome association (GPA) prediction can broaden the understanding of biological mechanisms underlying complex phenotypic traits (e.g., diseases and agronomic traits). Traditional deep matrix factorization (DMF)‐based GPA methods can integrate multiple data types and uncover nonlinear associations but often rely on low‐dimensional ...
Ran Duan, Wei Cao, Maozu Guo, Le Tian, Lingling Zhao   +4 more
wiley   +1 more source

Saturation of the Human Phenome [PDF]

Current Genomics, 2010
The phenome is the complete set of phenotypes resulting from genetic variation in populations of an organism. Saturation of a phenome implies the identification and phenotypic description of mutations in all genes in an organism, potentially constrained to those encoding proteins.
openaire   +3 more sources

Centre de ressources partagées PHENOME-EMPHASIS [PDF]

The PHENOME-EMPHASIS resource centre is an open and freely accessible web platform that enables the EMPHASIS community to share semantic resources containing descriptions of poolable elements (genetic resources, variables, etc.) produced by the plant ...
Tardieu, François, Neveu, Pascal, Kazemipour-Ricci, Farzaneh, Tireau, Anne, Chapuis, Romain, Alic, Isabelle, Adam, Boris, B., Burger, Philippe   +7 more
core  

SETD7 exacerbates diabetic nephropathy through activating A2B receptor-JAK2/STAT3 pathway

Cell & Bioscience
Objective Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD), and there has been growing attention towards the role of epigenetics in its pathogenesis.
Qiuyuan Huang, Wen Zhong, Ruoxue Chen, Shenhan Xu, Huibin Wang, Jintao He, Yajie Hu, Honghong Chen, Chunxiang Fan, Xinhua Liu   +9 more
doaj   +1 more source

Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus

Scientific Reports, 2017
Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation.
Zhi Yang Tam, Sean Pin Ng, Ling Qiao Tan, Chih-Hsien Lin, Dietrich Rothenbacher, Jochen Klenk, Bernhard Otto Boehm, SPC Team, ActiFE Study Group   +8 more
doaj   +1 more source

Molecular insights and translational opportunities to enhance heat tolerance in rice

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana, Chanderkant Chaudhary, Rajat Pruthi, Mansi Sharma, Bhupinderjeet Singh, Ravi Kiran Reddy Kondi, Mallesham Bulle, Prasanta K. Subudhi   +7 more
wiley   +1 more source

Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations [PDF]

Background Glycated hemoglobin (HbA1c) measures the average blood sugar level over the past three months. As a vital biomarker of blood glucose levels, it is used to diagnose Type-2 diabetes mellitus (T2D) and monitor glycemic control.
Daudi Jjingo (197635), Segun Fatumo (2226484), Chisom Soremekun (11780231), Amarachukwu Nwagbata (21453833), Sapna Sharma (210203), Annette Peters (62601), Oyesola Ojewunmi (5302028), Oyekanmi Nash (4342369), David Patrick Kateete (8446950), Homa Bazireh (21453836), Chiara Batini (20339946), Harald Grallert (72666)   +11 more
core  

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science
mRNA vaccines offer great potential for cancer immunotherapy, yet efficient delivery of antigen‐encoding mRNA to antigen‐presenting cells (APCs) in lymphoid organs remains a significant challenge.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
doaj   +1 more source