Results 81 to 90 of about 30,931 (193)

Partial regression plot of the phenome of schizophrenia on the interleukin (IL)23/IL6/T helper (Th)17 axis score.

, 2022
Partial regression plot of the phenome of schizophrenia on the interleukin (IL)23/IL6/T helper (Th)17 axis score.
Abbas Al-Mulla (13977631), Arafat Hussein Al-Dujaili (13977634), Hussein Kadhem Al-Hakeim (13354251), Monojit Debnath (642041), Michael Maes (2023633), Ali Fattah Al-Musawi (13977628)   +5 more
core   +1 more source

Ash2l deficiency impairs adipose tissue thermogenesis and exacerbates obesity in mice

Cellular & Molecular Biology Letters
Background Epigenetic regulation plays a pivotal role in adipocyte development and thermogenesis. Ash2l, a key component of the COMPASS (Complex of Proteins Associated with Set1) histone methyltransferase, regulates gene expression through epigenetic ...
Yajie Hu, Jialin Zhao, Chenxi Xiao, Jiayao Liu, Jie Xu, Shenhan Xu, Wen Zhong, Ruoxue Chen, Mengting He, Chunxiang Fan, Jun Chang, Xinhua Liu   +11 more
doaj   +1 more source

Advancing conservation breeding programs for marine invertebrates

Conservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam, Bart Shepherd, Kylie Lev, Rebecca Albright   +3 more
wiley   +1 more source

SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation

Cardiovascular Diabetology
Background Vasculopathy is the most prevalent complication of diabetes. Endothelial damage, a primary contributor to hyperglycemic vascular complications, impacts macro- and micro-vasculatures, causing functional impairment of multiple organs.
Wen Zhong, Ruoxue Chen, Jialin Zhao, Yuyu Zhang, Jintao He, Huibin Wang, Feng Zhu, Chunxiang Fan, Xinhua Liu   +8 more
doaj   +1 more source

Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis

Cellular & Molecular Biology Letters
Background Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes.
Chenxi Xiao, Zhenghua Su, Jialin Zhao, Subei Tan, Mengting He, Yuhui Li, Jiayao Liu, Jie Xu, Yajie Hu, Zhongzheng Li, Chunxiang Fan, Xinhua Liu   +11 more
doaj   +1 more source

Toward “Obesityomics”: Domain‐Specific Omics in Precision Obesity Medicine with a Brief AI Perspective

Obesity Reviews, EarlyView.
ABSTRACT Background Obesity's global rise has outpaced the effectiveness of “one‐size‐fits‐all” prevention and treatment strategies. The promise of precision medicine lies in addressing the etiological and biological diversity of obesity and transforming it into actionable endotypes.
Nadia Abu Samra, Sara G. I. Suliman, Mohammed Al‐Hadad, Dorret I. Boomsma, Fadwa Alhantoobi, Maithah Alsamahi, Haneen Abufarajallah, Alia Al Tikriti, Zeyar Aung, Selena Richards, Abdulrahim Sajini, Mira Mousa, Fatima Sulaiman, Wael Osman   +13 more
wiley   +1 more source

Towards a wheat phenome atlas and a phenome atlas toolbox: What are they? What progress?

, 2008
A Phenome Map is a representation of all the regions of a genome that influence heritable phenotypic variation for a trait, and a Phenome Atlas consists of the integration of all available phenome maps with a description of the methodologies that were ...
Crouch, Jonathan, DeLacy, Ian H., Crossa, Jose, Braun, Hans-J., Edwards, David, Godwin, Ian D., Kilian, Andrzej, McLaren, Graham, Dreisigacker, Susanne, Arief, Vivi N., Manes, Yann, Wenzl, Peter, Ortiz, Rodomiro, Warburton, Marilyn, Davenport, Guy, Basford, Kaye E., Huttner, Eric, Duvieller, Etienne, Batley, Jacqueline, Singh, Ravi P., Dieters, Mark J., Lambrides, Christopher J., Payne, Thomas   +22 more
core  

Comparative Genome‐Wide Association Studies of Metabolites and Grain‐Related Traits in Common Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large‐scale metabolome analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and 33 grain‐related traits in a diverse panel of natural accessions and
Guoguo Lv, Yanyan Liu, Bingyang Zhang, Ranran Shen, Maosong Yu, Yongyang Wu, Wanting Du, Xinru Yuan, Congwei Sun, Yan Yan, Wei Chen, Feng Chen   +11 more
wiley   +1 more source

Construction of a neuro-immune-cognitive pathway-phenotype underpinning the phenome of deficit schizophrenia

, 2020
Construction of a neuro-immune-cognitive pathway-phenotype underpinning the phenome of deficit ...
AH Al-Dujaili (15835364), HK Al-Hakeim (15835253), AF Almulla (15835250), M Maes (13320648)   +3 more
core  

PHESANT: a tool for performing automated phenome scans in UK Biobank

, 2017
MotivationEpidemiological cohorts typically contain a diverse set of phenotypes such that automation of phenome scans is non-trivial, because they require highly heterogeneous models.
Louise A C Millard, Neil M Davies, George Davey Smith, Kate Tilling, Tom R Gaunt   +4 more
core   +1 more source