Results 81 to 90 of about 30,200 (240)

The phenome-wide distribution of genetic variance [PDF]

, 2015
A general observation emerging from estimates of additive genetic variance in sets of functionally or developmentally related traits is that much of the genetic variance is restricted to few trait combinations as a consequence of genetic covariance among
Chenoweth, Stephen F., Allen, Scott L., McGuigan, Katrina, Blows, Mark W., Collet, Julie M.   +4 more
core   +1 more source

Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To characterise multi‐kingdom salivary microbiome profiles across clinically defined periodontal states and identify stage‐specific taxonomic and functional alterations using shotgun metagenomic sequencing. Materials and Methods In this cross‐sectional study, 204 adults (mean age 40.3 ± 7.6 years) from the SECRETO study (NCT01934725 ...
Muhammed Manzoor, Jaakko Leskelä, Eija Könönen, Leo Lahti, Jukka Putaala, Pirkko J. Pussinen, Susanna Paju   +6 more
wiley   +1 more source

Ash2l deficiency impairs adipose tissue thermogenesis and exacerbates obesity in mice

Cellular & Molecular Biology Letters
Background Epigenetic regulation plays a pivotal role in adipocyte development and thermogenesis. Ash2l, a key component of the COMPASS (Complex of Proteins Associated with Set1) histone methyltransferase, regulates gene expression through epigenetic ...
Yajie Hu, Jialin Zhao, Chenxi Xiao, Jiayao Liu, Jie Xu, Shenhan Xu, Wen Zhong, Ruoxue Chen, Mengting He, Chunxiang Fan, Jun Chang, Xinhua Liu   +11 more
doaj   +1 more source

Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis

Cellular & Molecular Biology Letters
Background Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes.
Chenxi Xiao, Zhenghua Su, Jialin Zhao, Subei Tan, Mengting He, Yuhui Li, Jiayao Liu, Jie Xu, Yajie Hu, Zhongzheng Li, Chunxiang Fan, Xinhua Liu   +11 more
doaj   +1 more source

Towards a wheat phenome atlas and a phenome atlas toolbox: What are they? What progress?

, 2008
A Phenome Map is a representation of all the regions of a genome that influence heritable phenotypic variation for a trait, and a Phenome Atlas consists of the integration of all available phenome maps with a description of the methodologies that were ...
Crouch, Jonathan, DeLacy, Ian H., Crossa, Jose, Braun, Hans-J., Edwards, David, Godwin, Ian D., Kilian, Andrzej, McLaren, Graham, Dreisigacker, Susanne, Arief, Vivi N., Manes, Yann, Wenzl, Peter, Ortiz, Rodomiro, Warburton, Marilyn, Davenport, Guy, Basford, Kaye E., Huttner, Eric, Duvieller, Etienne, Batley, Jacqueline, Singh, Ravi P., Dieters, Mark J., Lambrides, Christopher J., Payne, Thomas   +22 more
core  

Phenome-wide association study results of monounsaturated fatty acids (MUFAs) genetic risk score.

, 2022
(XLSX)
Dipender Gill (5514923), Loukas Zagkos (14309460), Abbas Dehghan (174878), Fotios Koskeridis (6861581), Rui Pinto (832195), Fotios Drenos (113686), Paul Elliott (27295), Ioanna Tzoulaki (257920), Verena Zuber (719156), Marie-Joe Dib (12000806), Georgios Markozannes (4406458), Kostas Tsilidis (2590939)   +11 more
core   +1 more source

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, EarlyView.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

Journal of Periodontal Research, EarlyView.
This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali, Jing Kang, Simon Haworth, Alessandro Polizzi, Gaetano Isola   +4 more
wiley   +1 more source

SETD7 exacerbates diabetic nephropathy through activating A2B receptor-JAK2/STAT3 pathway

Cell & Bioscience
Objective Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD), and there has been growing attention towards the role of epigenetics in its pathogenesis.
Qiuyuan Huang, Wen Zhong, Ruoxue Chen, Shenhan Xu, Huibin Wang, Jintao He, Yajie Hu, Honghong Chen, Chunxiang Fan, Xinhua Liu   +9 more
doaj   +1 more source

Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus

Scientific Reports, 2017
Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation.
Zhi Yang Tam, Sean Pin Ng, Ling Qiao Tan, Chih-Hsien Lin, Dietrich Rothenbacher, Jochen Klenk, Bernhard Otto Boehm, SPC Team, ActiFE Study Group   +8 more
doaj   +1 more source