Results 61 to 70 of about 27,998 (235)

Phenome-wide association studies as a research tool for identifying new pathogenetic links

Кардиоваскулярная терапия и профилактика
The accumulation of biospecimens associated with large-scale clinical data (data from electronic medical records, epidemiological and other large-scale studies) has made it possible to conduct studies aimed at studying associations between genetic ...
N. A. Mashkina, A. I. Ershova, O. V. Kopylova, O. M. Drapkina   +3 more
doaj   +1 more source

Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation

Cell Death and Disease, 2022
Adipogenesis is a complex cascade involved with the preadipocytes differentiation towards mature adipocytes, accelerating the onset of obesity. Histone methyltransferase SET and MYND domain-containing protein 2 (Smyd2), is involved in a variety of ...
Haibi Su, Chen Meng, Jie Xu, Zhenghua Su, Chenxi Xiao, Di Yang   +5 more
doaj   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone

Molecules, 2020
The discovery of IDO1 and HDAC1 dual inhibitors may provide a novel strategy for cancer treatment by taking advantages of both immunotherapeutic and epigenetic drugs. In this paper, saprorthoquinone (1) and 13 of its analogues from Salvia prionitis Hance
Yang Lin, Heyanhao Zhang, Tong Niu, Mei-Lin Tang, Jun Chang   +4 more
doaj   +1 more source

Wearable‐Derived Diurnal Alignment Between Physical Activity and Device Temperature Predicts Future Disease and Mortality Risk

Advanced Science, EarlyView.
Wearable‐derived diurnal alignment between physical activity and device temperature, decomposed into 24 h coupling strength (M24), phase deviation (D24), and 12 h harmonic magnitude (M12), is examined in approximately 90,000 UK Biobank participants.
Han Chen, Jiahe Wei, Jonathan Cedernaes, Christian Benedict, Athanasios Tsanas, Zhi Cao, Xiao Tan   +6 more
wiley   +1 more source

Phenome-wide association study results for measured height in non-Hispanic White individuals in MVP. [PDF]

, 2022
(XLSX)
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Phenome-wide significant trait associations with measured height in non-Hispanic Black individuals. [PDF]

, 2022
(XLSX)
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Towards a wheat phenome atlas and a phenome atlas toolbox: What are they? What progress? [PDF]

, 2008
A Phenome Map is a representation of all the regions of a genome that influence heritable phenotypic variation for a trait, and a Phenome Atlas consists of the integration of all available phenome maps with a description of the methodologies that were ...
Crouch, Jonathan, DeLacy, Ian H., Crossa, Jose, Braun, Hans-J., Edwards, David, Godwin, Ian D., Kilian, Andrzej, McLaren, Graham, Dreisigacker, Susanne, Arief, Vivi N., Manes, Yann, Wenzl, Peter, Ortiz, Rodomiro, Warburton, Marilyn, Davenport, Guy, Basford, Kaye E., Huttner, Eric, Duvieller, Etienne, Batley, Jacqueline, Singh, Ravi P., Dieters, Mark J., Lambrides, Christopher J., Payne, Thomas   +22 more
core