Results 71 to 80 of about 30,200 (240)
Yeast, EarlyView.ABSTRACT The knockout strain collection of Saccharomyces cerevisiae has served as a valuable resource for functional genomics and yeast‐based biotechnology studies. A comprehensive single‐gene knockout strain collection, covering nearly all non‐essential genes, together with complementary mutant collections for essential genes, including temperature ...
Takashi Hirasawa
wiley +1 more source
, 2018 "Phenomics" is an emerging area of research whose aspiration is the systematic measurement of the physical, physiological and biochemical traits (the phenome) belonging to a given individual or collection of individuals. Non-destructive or minimally invasive techniques allow repeated measurements across time to follow phenotypes as a function of ...
Marcos Egea-Cortines, John Doonan
openaire +3 more sources
Brain Pathology, EarlyView.In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles +15 more
wiley +1 more source
Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. [PDF]
, 2016 We performed a Phenome-Wide Association Study (PheWAS) to identify interrelationships between the immune system genetic architecture and a wide array of phenotypes from two de-identified electronic health record (EHR) biorepositories.
Gerhard, Glenn S. +29 more
core +2 more sources
Cladistics, EarlyView.Abstract Targeted enrichment of ultraconserved elements (UCEs) is a powerful tool for resolving phylogeny in groups with limited morphological or molecular data. Here, we use UCEs to reconstruct the first comprehensive phylogeny of the chiton superfamily Cryptoplacoidea, including museum material up to 133 years old.
Katarzyna Vončina +4 more
wiley +1 more source
Hypobaric hypoxia-driven energy metabolism disturbance facilitates vascular endothelial dysfunction
Redox BiologyHypobaric hypoxia in plateau environments inevitably disrupts metabolic homeostasis and contributes to high-altitude diseases. Vascular endothelial cells play a crucial role in maintaining vascular homeostasis. However, it remains unclear whether hypoxia-
Yuyu Zhang +11 more
doaj +1 more source
Advancing conservation breeding programs for marine invertebrates
Conservation Biology, EarlyView.Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam +3 more
wiley +1 more source
Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database [PDF]
, 2015 The Mouse Phenome Database was originally conceived as a platform for the integration of phenotype data collected on a defined collection of 40 inbred mouse strains-the phenome panel.
Churchill, Gary +5 more
core +1 more source
Human Pancreatic Cancer Organoids
Cell Proliferation, EarlyView.This guideline establishes a comprehensive framework for the application of patient‐derived pancreatic cancer organoids. It outlines the stringent technical requirements and testing methods necessary to ensure high fidelity to the original tumor tissue, including morphological assessment, pathological biomarker expression (e.g., CK19, CK7), and genetic
Aina He +44 more
wiley +1 more source
SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation
Cardiovascular DiabetologyBackground Vasculopathy is the most prevalent complication of diabetes. Endothelial damage, a primary contributor to hyperglycemic vascular complications, impacts macro- and micro-vasculatures, causing functional impairment of multiple organs.
Wen Zhong +8 more
doaj +1 more source