Results 91 to 100 of about 27,998 (235)

Human Pancreatic Cancer Organoids

Cell Proliferation, EarlyView.
This guideline establishes a comprehensive framework for the application of patient‐derived pancreatic cancer organoids. It outlines the stringent technical requirements and testing methods necessary to ensure high fidelity to the original tumor tissue, including morphological assessment, pathological biomarker expression (e.g., CK19, CK7), and genetic
Aina He, Xiaolin Lin, Xiaozhe Qian, Jiasheng Mu, Zhonghua Tao, Jin Gu, Yonggang Wang, Ting Han, Hongling Zhao, Yalong Wang, Jian Zhang, Zunqiang Zhou, Ligang Xing, Changchun Zhou, Dongyuan Zhu, Zengjun Liu, Gang Chen, Qinghe Zhou, Xiaoguang Wang, Shasha Zhao, Xiao Liu, Dongyan Cao, Bin Yu, Zebing Liu, Jiabei Wang, Gengming Niu, Guiying Wei, Maorong Chen, Weiping Wang, Xiaonan Kang, Junmei Zhou, Shuai Gong, Ying Xie, Jianming Zhang, Xianming Kong, Chunyan Dong, Yanmei Zou, Lina Tang, Aijin Ma, Hua Xiong, Xuemei Liu, Tongbiao Zhao, Jie Hao, Xiuying Xiao, Dongxi Xiang   +44 more
wiley   +1 more source

Phenome-wide analysis of genome-wide polygenic scores [PDF]

, 2015
Genome-wide polygenic scores (GPS), which aggregate the effects of thousands of DNA variants from genome-wide association studies (GWAS), have the potential to make genetic predictions for individuals.
Dale, P. S., Krapohl, E., Zabaneh, D, O'Reilly, P F, G Breen, Dale, P S, S von Stumm, Dale, Philip, K Rimfeld, Rimfeld, K., O'Reilly, P. F., Breen, G, Euesden, J, J Euesden, P F O'Reilly, Euesden, J., Pingault, J. B., Plomin, R., Breen, G., Rimfeld, K, Zabaneh, Magda Delilah; id_orcid, Krapohl, E, Von Stumm, Sophie, J-B Pingault, O'Reilly, Paul Francis, Pingault, Jean-Baptiste, Plomin, R, D Zabaneh, Euesden, Jack, Breen, Gerome Daniel; id_orcid, Pingault, J.-B., P S Dale, Krapohl, Eva Maria Laura, Plomin, Robert Joseph, Pingault, J-B, Von Stumm, S., Rimfeld, Kaili, E Krapohl, R Plomin, Zabaneh, D.   +39 more
core   +1 more source

Cell‐based crop phenotyping for future climates

New Phytologist, EarlyView.
Flow‐chart diagram illustrating the proposed pathway for improving the throughput of fluorescence imaging‐based phenotyping by using robotics and machine learning (ML) approaches. Summary Abiotic stress tolerance has been significantly weakened in modern crops during the domestication process.
Sergey Shabala, Ping Yun, Zhong‐Hua Chen, Meixue Zhou, Min Yu, Nadia Bazihizina   +5 more
wiley   +1 more source

Root trait dynamics of historical canola varieties under low and high nitrogen supply

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Nitrogen fertilizer is a major input cost in crop production, making it crucial to enhance nitrogen use efficiency (NUE) to reduce fertilizer dependence without compromising yields. Root system architecture (RSA) is a key determinant of nutrient acquisition, particularly under nutrient‐limited conditions.
Shankar Pahari, Raju Soolanayakanahally
wiley   +1 more source

Hypobaric hypoxia-driven energy metabolism disturbance facilitates vascular endothelial dysfunction

Redox Biology
Hypobaric hypoxia in plateau environments inevitably disrupts metabolic homeostasis and contributes to high-altitude diseases. Vascular endothelial cells play a crucial role in maintaining vascular homeostasis. However, it remains unclear whether hypoxia-
Yuyu Zhang, Jinghuan Wang, Mengting He, Jiayao Liu, Jialin Zhao, JinTao He, Caiyun Wang, Yuhui Li, Chenxi Xiao, Chunxiang Fan, Jun Chang, Xinhua Liu   +11 more
doaj   +1 more source

Affordable Phenomics special topic—Foreword for The Plant Phenome Journal

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract The Affordable Phenomics special topic in The Plant Phenome Journal showcased recent advances that expand the accessibility, cost‐effectiveness, and scalability of plant phenotyping technologies. This collection of 15 articles presented innovative approaches, ranging from low‐cost sensors and open‐source analytical pipelines to artificial ...
Valerio Hoyos‐Villegas, Michael A. Gore   +1 more
wiley   +1 more source

SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation

Cardiovascular Diabetology
Background Vasculopathy is the most prevalent complication of diabetes. Endothelial damage, a primary contributor to hyperglycemic vascular complications, impacts macro- and micro-vasculatures, causing functional impairment of multiple organs.
Wen Zhong, Ruoxue Chen, Jialin Zhao, Yuyu Zhang, Jintao He, Huibin Wang, Feng Zhu, Chunxiang Fan, Xinhua Liu   +8 more
doaj   +1 more source

Philosophy of phenomic prediction and its incompatibility with causal inference

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Breeding programs need to make decisions frequently to improve populations and develop varieties efficiently. These needs led to the development of genomic prediction in the early 2000s and phenomic prediction in the mid‐2010s. In practice, phenomic prediction techniques rely on the same statistical tools and computational frameworks as other ...
Mitchell J. Feldmann, Fangyi Wang, Daniel E. Runcie   +2 more
wiley   +1 more source

Ash2l deficiency impairs adipose tissue thermogenesis and exacerbates obesity in mice

Cellular & Molecular Biology Letters
Background Epigenetic regulation plays a pivotal role in adipocyte development and thermogenesis. Ash2l, a key component of the COMPASS (Complex of Proteins Associated with Set1) histone methyltransferase, regulates gene expression through epigenetic ...
Yajie Hu, Jialin Zhao, Chenxi Xiao, Jiayao Liu, Jie Xu, Shenhan Xu, Wen Zhong, Ruoxue Chen, Mengting He, Chunxiang Fan, Jun Chang, Xinhua Liu   +11 more
doaj   +1 more source

Genetic analysis of the near-infrared spectral phenome of a global Eucalyptus species [PDF]

, 2013
Understanding the genetic-based variability in plant phytochemical compounds provides insight into the evolutionary and ecological processes affecting those traits.
Bradley Potts (14747029), Rene Vaillancourt (14751562), Julianne O'Reilly-Wapstra (14745781), Barbour, R (15572066), Jules Freeman (14736976)   +4 more
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