Results 91 to 100 of about 30,931 (193)

SETD7 exacerbates diabetic nephropathy through activating A2B receptor-JAK2/STAT3 pathway

Cell & Bioscience
Objective Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD), and there has been growing attention towards the role of epigenetics in its pathogenesis.
Qiuyuan Huang, Wen Zhong, Ruoxue Chen, Shenhan Xu, Huibin Wang, Jintao He, Yajie Hu, Honghong Chen, Chunxiang Fan, Xinhua Liu   +9 more
doaj   +1 more source

Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus

Scientific Reports, 2017
Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation.
Zhi Yang Tam, Sean Pin Ng, Ling Qiao Tan, Chih-Hsien Lin, Dietrich Rothenbacher, Jochen Klenk, Bernhard Otto Boehm, SPC Team, ActiFE Study Group   +8 more
doaj   +1 more source

Integrated Analysis of Grapevine Responses to Winter Pruning Reveals Temperature‐Associated, Polyphenol‐Rich Xylem Occlusions

Plant, Cell &Environment, EarlyView.
ABSTRACT Perennial crops are continually wounded throughout cultivation. To limit pathogen infection and tissue dehydration, plants have evolved a range of wound responses that protect damaged tissues. These responses include changes in gene expression and the synthesis of protective compounds such as polyphenols.
Marilou Camboué, Monica Galar‐Martínez, Grégoire Loupit, Paraskevi Charalambous, Enric Zehraoui, Joseph Tran, Josep Valls Fonayet, Luis Gonzaga Santesteban, Notburga Gierlinger, Sarah Jane Cookson   +9 more
wiley   +1 more source

Table_1_Brooding and neuroticism are strongly interrelated manifestations of the phenome of depression.docx

, 2023
IntroductionWe found that neuroticism may be identified as a subclinical manifestation of the phenome of depression, comprising depressive and anxiety symptoms, and suicidal behaviors.
Asara Vasupanrajit (15356797), Michael Maes (2023633), Ketsupar Jirakran (13742623), Chavit Tunvirachaisakul (5103047)   +3 more
core   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science
mRNA vaccines offer great potential for cancer immunotherapy, yet efficient delivery of antigen‐encoding mRNA to antigen‐presenting cells (APCs) in lymphoid organs remains a significant challenge.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
doaj   +1 more source

Multi‐Trait GWAS Analyses of Blood Pressure Traits Provide Limited Gains in Locus Discovery or Polygenic Risk Score Performance Compared to Single‐Trait GWAS

Genetic Epidemiology, Volume 50, Issue 8, December 2026.
ABSTRACT High blood pressure (BP) represents a major cause of life‐threatening cardiovascular conditions. GWAS have identified >2000 BP‐associated signals. BP‐GWAS usually analyze each BP trait individually. However, multi‐trait GWAS may yield novel loci and improve polygenic risk scores (PRS) prediction. We explored whether multi‐trait BP‐GWAS can: (i)
Yujia Ma, Anna D. Argoty‐Pantoja, Tian Xie, Michael R. Barnes, Patricia B. Munroe, Claudia P. Cabrera, Harold Snieder, Helen R. Warren, UMCG Genetics Lifelines Initiative (UGLI) group author: LifeLines Cohort Study, Raul Aguirre‐Gamboa, Patrick Deelen, Lude Franke, Jan A. Kuivenhoven, Esteban A. Lopera Maya, Ilja M. Nolte, Serena Sanna, Harold Snieder, Morris A. Swertz, Peter M. Visscher, Judith M. Vonk, Cisca Wijmenga, Naomi Wray   +21 more
wiley   +1 more source

Root trait dynamics of historical canola varieties under low and high nitrogen supply

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Nitrogen fertilizer is a major input cost in crop production, making it crucial to enhance nitrogen use efficiency (NUE) to reduce fertilizer dependence without compromising yields. Root system architecture (RSA) is a key determinant of nutrient acquisition, particularly under nutrient‐limited conditions.
Shankar Pahari, Raju Soolanayakanahally
wiley   +1 more source

Phenome-wide and genome-wide analyses of quality of life in schizophrenia – ERRATUM

BJPsych Open, 2021
Raha Pazoki, Bochao Danae Lin, Kristel R. van Eijk, Dick Schijven, Sonja de Zwarte, Sinan Guloksuz, Jurjen J. Luykx   +6 more
doaj   +1 more source

Affordable Phenomics special topic—Foreword for The Plant Phenome Journal

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract The Affordable Phenomics special topic in The Plant Phenome Journal showcased recent advances that expand the accessibility, cost‐effectiveness, and scalability of plant phenotyping technologies. This collection of 15 articles presented innovative approaches, ranging from low‐cost sensors and open‐source analytical pipelines to artificial ...
Valerio Hoyos‐Villegas, Michael A. Gore   +1 more
wiley   +1 more source

Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy

Advanced Science
Ischemic stroke (IS) is a leading cause of mortality and disability worldwide, but effective therapeutic options are limited. In this study, a chemical proteomic strategy is employed using the active compound procyanidin B3 (PB3) as a chemical probe to ...
Heyanhao Zhang, Yuyu Zhang, Yibo Chen, Wen Zhong, Subei Tan, Jinghuan Wang, Huanren Yan, Ning Yan, Mengjia Lin, Xinhua Liu, Jun Chang   +10 more
doaj   +1 more source