Results 51 to 60 of about 30,200 (240)

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Culm Morphological Analysis in Moso Bamboo Reveals the Negative Regulation of Internode Diameter and Thickness by Monthly Precipitation

Plants
The neglect of Moso bamboo’s phenotype variations hinders its broader utilization, despite its high economic value globally. Thus, this study investigated the morphological variations of 16 Moso bamboo populations.
Qianwen Zhang, Xue Chu, Zhipeng Gao, Yulong Ding, Feng Que, Zishan Ahmad, Fen Yu, Muthusamy Ramakrishnan, Qiang Wei   +8 more
doaj   +1 more source

Association of gut microbiota with bone mineral density in 55 – 65 years old rural Han residents of Taizhou city

Zhongguo gonggong weisheng, 2022
ObjectiveTo examine the relationship between intestinal flora and bone mineral density among rural Han residents aged 55 – 65 years in Taizhou city, Jiangsu province for exploring novel approaches to osteoporosis prevention.
Dan-tong YANG, Si-bo ZHU, Yan-feng JIANG
doaj   +1 more source

The age-phenome database [PDF]

SpringerPlus, 2012
Data linking specific ages or age ranges with disease are abundant in biomedical literature. However, these data are organized such that searching for age-phenotype relationships is difficult. Recently, we described the Age-Phenome Knowledge-base (APK), a computational platform for storage and retrieval of information concerning age-related phenotypic ...
Geifman, Nophar, Rubin, Eitan
openaire   +3 more sources

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients

BMC Medicine, 2022
Background COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to infectious diseases such as influenza, little
Zhonghan Sun, Zhi-Gang Song, Chenglin Liu, Shishang Tan, Shuchun Lin, Jiajun Zhu, Fa-Hui Dai, Jian Gao, Jia-Lei She, Zhendong Mei, Tao Lou, Jiao-Jiao Zheng, Yi Liu, Jiang He, Yuanting Zheng, Chen Ding, Feng Qian, Yan Zheng, Yan-Mei Chen   +18 more
doaj   +1 more source

Predictors of Change in Severity of Self‐Injurious Behaviors in Preschool‐Aged Autistic Children

Autism Research, EarlyView.
ABSTRACT Self‐injurious behaviors (SIBs) affect up to 50% of autistic individuals and significantly impact quality of life and everyday functioning. Cross‐sectional studies link the presence of SIB to lower IQ, altered sensory responsivity, and poor emotion regulation, yet their effect on changes in SIB severity from early childhood to school age in ...
Joseph Boyle, Andrew Dakopolos, Olivia Surgent, Joshua K. Lee, Derek S. Andrews, Brianna Heath, Jason Smucny, Marjorie Solomon, Sally J. Rogers, Christine Wu Nordahl   +9 more
wiley   +1 more source

A Mendelian randomization study of the entire phenome to explore the causal links between epilepsy

Brain and Behavior
Objective The causes and triggering factors of epilepsy are still unknown. The results of genome‐wide association studies can be utilized for a phenome‐wide association study using Mendelian randomization (MR) to identify potential risk factors for ...
Wei Zhang, Li‐Ming Zhang, Lin Zhi, Ji Qi, Jue He   +4 more
doaj   +1 more source