Results 51 to 60 of about 30,931 (193)

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Syndromic male subfertility: A network view of genome–phenome associations

, 2022
Background: Male infertility is a disorder of the reproductive system with a highly complex genetic landscape. In most cases, the reason for male infertility remains unknownhowever, the importance of genetic abnormalities in the diagnosis of subfertility/
Neža Pogorevc, Tanja Kunej, Pogorevc, Neža, Simon Horvat, Živa Kolenc, Peterlin, Borut, Špela Mikec, Kolenc, Živa, Horvat, Simon, Mikec, Špela, Kunej, Tanja, Borut Peterlin   +11 more
core   +1 more source

Culm Morphological Analysis in Moso Bamboo Reveals the Negative Regulation of Internode Diameter and Thickness by Monthly Precipitation

Plants
The neglect of Moso bamboo’s phenotype variations hinders its broader utilization, despite its high economic value globally. Thus, this study investigated the morphological variations of 16 Moso bamboo populations.
Qianwen Zhang, Xue Chu, Zhipeng Gao, Yulong Ding, Feng Que, Zishan Ahmad, Fen Yu, Muthusamy Ramakrishnan, Qiang Wei   +8 more
doaj   +1 more source

List of the projects selected from the Mouse Phenome Database (https://phenome.jax.org) for this study for each parameter analyzed.

, 2023
List of the projects selected from the Mouse Phenome Database (https://phenome.jax.org) for this study for each parameter analyzed.
Christian Heumann (487880), Bernhard Aigner (476265)   +1 more
core   +1 more source

Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients

BMC Medicine, 2022
Background COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to infectious diseases such as influenza, little
Zhonghan Sun, Zhi-Gang Song, Chenglin Liu, Shishang Tan, Shuchun Lin, Jiajun Zhu, Fa-Hui Dai, Jian Gao, Jia-Lei She, Zhendong Mei, Tao Lou, Jiao-Jiao Zheng, Yi Liu, Jiang He, Yuanting Zheng, Chen Ding, Feng Qian, Yan Zheng, Yan-Mei Chen   +18 more
doaj   +1 more source

Association of gut microbiota with bone mineral density in 55 – 65 years old rural Han residents of Taizhou city

Zhongguo gonggong weisheng, 2022
ObjectiveTo examine the relationship between intestinal flora and bone mineral density among rural Han residents aged 55 – 65 years in Taizhou city, Jiangsu province for exploring novel approaches to osteoporosis prevention.
Dan-tong YANG, Si-bo ZHU, Yan-feng JIANG
doaj   +1 more source

Characterizing Autism Phenotype Onset in the Electronic Health Records to Enable Age‐Specific Screening

Autism Research, EarlyView.
ABSTRACT Autism exhibits substantial phenotypic heterogeneity, yet age‐dependent variation in phenotypic profiles and onset timing remains poorly understood. We aimed to characterize stage‐specific phenotypes and temporal onset patterns of autism using longitudinal electronic health records (EHRs).
Fangyi Chen, Jerard Kneifati‐Hayek, Charlotte Zelin, Da Wu, Quan M. Nguyen, Casey N. Ta, Cong Liu, Kai Wang, Wendy K. Chung, Chunhua Weng   +9 more
wiley   +1 more source

A Mendelian randomization study of the entire phenome to explore the causal links between epilepsy

Brain and Behavior
Objective The causes and triggering factors of epilepsy are still unknown. The results of genome‐wide association studies can be utilized for a phenome‐wide association study using Mendelian randomization (MR) to identify potential risk factors for ...
Wei Zhang, Li‐Ming Zhang, Lin Zhi, Ji Qi, Jue He   +4 more
doaj   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source