Results 51 to 60 of about 27,998 (235)

The age-phenome database [PDF]

SpringerPlus, 2012
Data linking specific ages or age ranges with disease are abundant in biomedical literature. However, these data are organized such that searching for age-phenotype relationships is difficult. Recently, we described the Age-Phenome Knowledge-base (APK), a computational platform for storage and retrieval of information concerning age-related phenotypic ...
Geifman, Nophar, Rubin, Eitan
openaire   +3 more sources

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. [PDF]

, 2016
We performed a Phenome-Wide Association Study (PheWAS) to identify interrelationships between the immune system genetic architecture and a wide array of phenotypes from two de-identified electronic health record (EHR) biorepositories.
Gerhard, Glenn S., Yuki Bradford (496693), Marylyn D. Ritchie (201209), James E. Crowe Jr (151303), Verma, Anurag, James E Crowe, Anna O Basile, Marylyn D Ritchie, Bradford, Yuki, Pendergrass, Sarah A., Crowe, James E., Glenn S Gerhard, David Carey (2936301), Yuki Bradford, Carey, David, Glenn S. Gerhard (259020), Anurag Verma, Sarah A. Pendergrass (87900), Tromp, Gerard, Helena Kuivaniemi (496630), Basile, Anna O., Kuivaniemi, Helena, Ritchie, Marylyn D., Helena Kuivaniemi, Anna O. Basile (2936304), Gerard Tromp, Anurag Verma (669308), Sarah A Pendergrass, David Carey, Gerard Tromp (63007)   +29 more
core   +1 more source

The phenome-wide distribution of genetic variance [PDF]

, 2015
A general observation emerging from estimates of additive genetic variance in sets of functionally or developmentally related traits is that much of the genetic variance is restricted to few trait combinations as a consequence of genetic covariance among
Chenoweth, Stephen F., Allen, Scott L., McGuigan, Katrina, Blows, Mark W., Collet, Julie M.   +4 more
core   +1 more source

Adverse Childhood Experiences Predict the Phenome of Affective Disorders and These Effects Are Mediated by Staging, Neuroimmunotoxic and Growth Factor Profiles

Cells, 2022
Adverse childhood experiences (ACEs) enhance pro-inflammatory and pro-oxidant responses. In affective disorders, recent precision nomothetic psychiatry studies disclosed new pathway phenotypes, including an ROI—reoccurrence of illness (ROI)—oxidative ...
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Monojit Debnath, Agnieska Basta-Kaim, Marta Kubera, Abbas F. Almulla, Atapol Sughondhabirom   +9 more
doaj   +1 more source

Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database [PDF]

, 2015
The Mouse Phenome Database was originally conceived as a platform for the integration of phenotype data collected on a defined collection of 40 inbred mouse strains-the phenome panel.
Churchill, Gary, Molly A. Bogue, Elissa J. Chesler, Bogue, Molly A, Chesler, Elissa J, Gary A. Churchill   +5 more
core   +1 more source

The Future of Phenomics [PDF]

Animal Frontiers, 2020
Baes, Christine, Schenkel, Flavio
openaire   +6 more sources

Top phenome-wide associations and closely related traits with genetically predicted height. [PDF]

, 2022
Top phenome-wide associations and closely related traits with genetically predicted height.
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Mouse Phenome Database (MPD). [PDF]

, 2011
The Mouse Phenome Project was launched a decade ago to complement mouse genome sequencing efforts by promoting new phenotyping initiatives under standardized conditions and collecting the data in a central public database, the Mouse Phenome Database (MPD;
Stephen C. Grubb, Molly A. Bogue, Stephen C Grubb, Carol J. Bult, Terry P. Maddatu, Carol J Bult, Bogue, Molly A, Maddatu, Terry P, Grubb, Stephen C, Bult, Carol J, Molly A Bogue, Terry P Maddatu   +11 more
core   +1 more source