Results 41 to 50 of about 27,998 (235)

Histone methyltransferase Smyd2 contributes to blood‐brain barrier breakdown in stroke

Clinical and Translational Medicine, 2022
Background The blood‐brain barrier (BBB) plays a principal role in the healthy and diseased central nervous systems, and BBB disruption after ischaemic stroke is responsible for increased mortality.
Jinghuan Wang, Wen Zhong, Qianwen Cheng, Chenxi Xiao, Jie Xu, Zhenghua Su, Haibi Su, Xinhua Liu   +7 more
doaj   +1 more source

The effects of adverse childhood experiences on depression and suicidal behaviors are partially mediated by neuroticism: A subclinical manifestation of major depression

Frontiers in Psychiatry, 2023
IntroductionNeuroticism, a personality trait, can predict major depressive disorder (MDD). The current study aims to determine whether a) neuroticism is a feature of the acute state of MDD, including suicidal behaviors (SB); and b) adverse childhood ...
Ketsupar Jirakran, Ketsupar Jirakran, Ketsupar Jirakran, Asara Vasupanrajit, Asara Vasupanrajit, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes   +12 more
doaj   +1 more source

Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans [PDF]

, 2023
Background: The variation in the rate at which humans age may be rooted in early events acting through the genomic regions that are influenced by such events and subsequently are related to health phenotypes in later life.
Y Zeng (7803473), MJ Adams (14212811), C Hayward (7641530), C Amador (21952982), A Campbell (7713596), CS Haley (21282596), Y Liu (4702669), DJ Porteous (7713812), KL Evans (11048373), M Li (3216264), X Bai (7490021), C Gao (81541), RM Walker (15900053), RA Madden (21952985), X Shen (7801967), P Navarro (21826118), AM McIntosh (14449110)   +16 more
core  

Pan-transcriptome analysis of pine wilt disease-resistant and susceptible Pinus species and a hybrid

Frontiers in Genetics
Pine trees, globally distributed and economically vital evergreen conifers, are threatened by pine wilt disease (PWD) attributed to the pine wood nematode (PWN).
Bae Young Choi, Dayoung Lee, Jaegyeong Jung, Yang-Gil Kim, Youn-Il Park, Kyu-Suk Kang, Donghwan Shim, Donghwan Shim   +7 more
doaj   +1 more source

SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases

Clinical and Translational Medicine, 2021
Background The methylation of lysine residues has been involved in the multiple biological and diseases processes. Recently, some particular non‐histone proteins have been elucidated to be methylated by SMYD2, a SET and MYND domain protein with lysine ...
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu   +8 more
doaj   +1 more source

The Biological Coherence of Human Phenome Databases [PDF]

, 2009
Disease networks are increasingly explored as a complement to networks centered around interactions between genes and proteins. The quality of disease networks is heavily dependent on the amount and quality of phenotype information in phenotype databases
Brunner, H.G., Huynen, Martijn A., Huynen, M.A., Oti, M.O., Oti, Martin, Brunner, Han G.   +5 more
core   +1 more source

Table_1_Brooding and neuroticism are strongly interrelated manifestations of the phenome of depression.docx [PDF]

, 2023
IntroductionWe found that neuroticism may be identified as a subclinical manifestation of the phenome of depression, comprising depressive and anxiety symptoms, and suicidal behaviors.
Asara Vasupanrajit (15356797), Michael Maes (2023633), Ketsupar Jirakran (13742623), Chavit Tunvirachaisakul (5103047)   +3 more
core   +1 more source

Brooding and neuroticism are strongly interrelated manifestations of the phenome of depression

Frontiers in Psychiatry, 2023
IntroductionWe found that neuroticism may be identified as a subclinical manifestation of the phenome of depression, comprising depressive and anxiety symptoms, and suicidal behaviors.
Asara Vasupanrajit, Asara Vasupanrajit, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Ketsupar Jirakran, Ketsupar Jirakran, Ketsupar Jirakran, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul   +16 more
doaj   +1 more source

Principles of phenomics in endometriosis [PDF]

Human Reproduction Update, 2012
Endometriosis has been associated with specific morphometric characteristics and pigmentary traits. The purpose of this study was to systematically review prior publications dealing with this aspect in order to revisit phenotypic information in the context of phenomics principles.Comprehensive searches of Pubmed, Medline and Embase were conducted to ...
P. Vigano, E. Somigliana, P. Panina, E. Rabellotti, P. Vercellini, M. Candiani   +5 more
openaire   +2 more sources

Phenome-wide significant trait associations with genetically-predicted height in non-Hispanic White individuals. [PDF]

, 2022
(XLSX)
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source