Results 41 to 50 of about 30,931 (193)

Phenome-wide analysis of genome-wide polygenic scores [PDF]

, 2015
Genome-wide polygenic scores (GPS), which aggregate the effects of thousands of DNA variants from genome-wide association studies (GWAS), have the potential to make genetic predictions for individuals.
Dale, P. S., Krapohl, E., Zabaneh, D, O'Reilly, P F, G Breen, Dale, P S, S von Stumm, Dale, Philip, K Rimfeld, Rimfeld, K., O'Reilly, P. F., Breen, G, Euesden, J, J Euesden, P F O'Reilly, Euesden, J., Pingault, J. B., Plomin, R., Breen, G., Rimfeld, K, Zabaneh, Magda Delilah; id_orcid, Krapohl, E, Von Stumm, Sophie, J-B Pingault, O'Reilly, Paul Francis, Pingault, Jean-Baptiste, Plomin, R, D Zabaneh, Euesden, Jack, Breen, Gerome Daniel; id_orcid, Pingault, J.-B., P S Dale, Krapohl, Eva Maria Laura, Plomin, Robert Joseph, Pingault, J-B, Von Stumm, S., Rimfeld, Kaili, E Krapohl, R Plomin, Zabaneh, D.   +39 more
core   +1 more source

Sex-specific variability of mouse strain data sets submitted to the Mouse Phenome Database https://phenome.jax.org.

, 2023
Sex-specific variability of mouse strain data sets submitted to the Mouse Phenome Database https://phenome.jax.org.
Christian Heumann (487880), Bernhard Aigner, Bernhard Aigner (476265), Christian Heumann   +3 more
core   +1 more source

Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation

Cell Death and Disease, 2022
Adipogenesis is a complex cascade involved with the preadipocytes differentiation towards mature adipocytes, accelerating the onset of obesity. Histone methyltransferase SET and MYND domain-containing protein 2 (Smyd2), is involved in a variety of ...
Haibi Su, Chen Meng, Jie Xu, Zhenghua Su, Chenxi Xiao, Di Yang   +5 more
doaj   +1 more source

Adverse Childhood Experiences Predict the Phenome of Affective Disorders and These Effects Are Mediated by Staging, Neuroimmunotoxic and Growth Factor Profiles

Cells, 2022
Adverse childhood experiences (ACEs) enhance pro-inflammatory and pro-oxidant responses. In affective disorders, recent precision nomothetic psychiatry studies disclosed new pathway phenotypes, including an ROI—reoccurrence of illness (ROI)—oxidative ...
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Monojit Debnath, Agnieska Basta-Kaim, Marta Kubera, Abbas F. Almulla, Atapol Sughondhabirom   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Software application profile:PHESANT: A tool for performing automated phenome scans in UK Biobank [PDF]

, 2017
Motivation: Epidemiological cohorts typically contain a diverse set of phenotypes such that automation of phenome scans is non-trivial, because they require highly heterogeneous models.
Gaunt, Tom R., Neil M Davies, Millard, Louise A.C., George Davey Smith, Davies, Neil M., Kate Tilling, Tom R Gaunt, Tilling, Kate, Louise AC Millard, Smith, George Davey   +9 more
core   +1 more source

List of urine analytes from National Phenome Centre

, 2021
List of all Barwon Infant Study urine analytes currently available, and potentially available from Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) from the Australian National Phenome Centre (NPC) at Murdoch University, Western ...
James Hedley (9598800)
core   +1 more source

Phenome-wide association studies as a research tool for identifying new pathogenetic links

Кардиоваскулярная терапия и профилактика
The accumulation of biospecimens associated with large-scale clinical data (data from electronic medical records, epidemiological and other large-scale studies) has made it possible to conduct studies aimed at studying associations between genetic ...
N. A. Mashkina, A. I. Ershova, O. V. Kopylova, O. M. Drapkina   +3 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone

Molecules, 2020
The discovery of IDO1 and HDAC1 dual inhibitors may provide a novel strategy for cancer treatment by taking advantages of both immunotherapeutic and epigenetic drugs. In this paper, saprorthoquinone (1) and 13 of its analogues from Salvia prionitis Hance
Yang Lin, Heyanhao Zhang, Tong Niu, Mei-Lin Tang, Jun Chang   +4 more
doaj   +1 more source