Results 21 to 30 of about 30,931 (193)

What new cell biology findings could bring to therapeutics: is it time for a phenome-project in Toxoplasma gondii? [PDF]

, 2009
"If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat" (SunTzu the Art of War, 544-496 BC).
Meissner, M., Klaus, K., Markus Meissner, Katrin Klaus   +3 more
core   +1 more source

Commentary on: Genetic predictors of GLP1 receptor agonist weight loss and side effects (Nature volume 653, pages 770-775 (2026)). [PDF]

J Diabetes Investig
Journal of Diabetes Investigation, EarlyView.
Toda G, Yamauchi T.
europepmc   +2 more sources

Phenotypic profiling of ABC transporter coding genes in Myxococcus xanthus

Frontiers in Microbiology, 2014
Information about a gene sometimes can be deduced by examining the impact of its mutation on phenotype. However, the genome-scale utility of the method is limited because, for nearly all model organisms, the majority of mutations result in little or no ...
Jinyuan eYan, Jinyuan eYan, Michael D Bradley, Jannice eFriedman, Roy D Welch   +4 more
doaj   +1 more source

Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study

Immunity & Ageing, 2022
Background The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are readily available circulatory immunity markers that are associated with components of frailty.
Hui Zhang, Meng Hao, Zixin Hu, Yi Li, Xiaoyan Jiang, Jiucun Wang, Li Jin, Zuyun Liu, Xiaofeng Wang, Xuehui Sun   +9 more
doaj   +1 more source

Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies. [PDF]

, 2020
Discovery of genotype-phenotype relationships remains a major challenge in clinical medicine. Here, we combined three sources of phenotypic data to uncover a new mechanism for rare and common diseases resulting from collagen secretion deficits.
Alkuraya, Fowzan, Melville, David, Gamazon, Eric, Cox, Nancy, Patel, Nisha, Hashem, Mais, Al-Faifi, Abdullah, Chen, Rui, Rushing, Amy, Knapik, Ela, Qi, Xinzi, Li, Bingshan, Unlu, Gokhan   +12 more
core   +1 more source

Histone Methyltransferase Dot1L Contributes to RIPK1 Kinase‐Dependent Apoptosis in Cerebral Ischemia/Reperfusion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Neuron apoptosis is a pivotal process for brain damage in cerebral ischemia. Dot1L (disruptor of telomeric silencing 1‐like) is only known histone H3K79 methyltransferase.
Jinghuan Wang, Wen Zhong, Haibi Su, Jie Xu, Di Yang, Xinhua Liu, Yi Zhun Zhu   +6 more
doaj   +1 more source

Top phenome-wide associations and closely related traits with genetically predicted height.

, 2022
Top phenome-wide associations and closely related traits with genetically predicted height.
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source

Inhibition of the cardiac fibroblast-enriched histone methyltransferase Dot1L prevents cardiac fibrosis and cardiac dysfunction

Cell & Bioscience, 2022
Background Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is the catalytic enzyme required for
Jie Xu, Jinghuan Wang, Fen Long, Wen Zhong, Haibi Su, Zhenghua Su, Xinhua Liu   +6 more
doaj   +1 more source

Mouse Phenome Database (MPD [PDF]

, 2007
The Mouse Phenome Database ...
Bogue, M A, Grubb, S C, Bult, C J, Molly A. Bogue, Stephen C. Grubb, Stephen C Grubb, Carol J. Bult, Terry P. Maddatu, Carol J Bult, Molly A Bogue, Maddatu, T P, Terry P Maddatu   +11 more
core   +1 more source

Partial regression plot of the phenome of schizophrenia on the generalized cognitive decline (G-CoDe) score.

, 2022
Partial regression plot of the phenome of schizophrenia on the generalized cognitive decline (G-CoDe) score.
Abbas Al-Mulla (13977631), Arafat Hussein Al-Dujaili (13977634), Hussein Kadhem Al-Hakeim (13354251), Monojit Debnath (642041), Michael Maes (2023633), Ali Fattah Al-Musawi (13977628)   +5 more
core   +1 more source