Results 21 to 30 of about 30,200 (240)
Biobanking across the phenome - at the center of chronic disease research [PDF]
, 2013 Recognized public health relevant risk factors such as obesity, physical inactivity, smoking or air pollution are common to many non-communicable diseases (NCDs). NCDs cluster and co-morbidities increase in parallel to age.
Nicole M Probst-Hensch +3 more
core +2 more sources
The Plant Pathology Journal, 2016 Pathogen infection in plants induces complex responses ranging from gene expression to metabolic processes in infected plants. In spite of many studies on biotic stress-related changes in host plants, little is known about the metabolic and phenotypic ...
Dhinesh Kumar Rajendran +6 more
doaj +1 more source
What new cell biology findings could bring to therapeutics: is it time for a phenome-project in Toxoplasma gondii? [PDF]
, 2009 "If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat" (SunTzu the Art of War, 544-496 BC).
Meissner, M. +5 more
core +1 more source
The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis
Cell Death and Disease, 2022 Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with increasing occurrence, high death rates, and unfavorable treatment regimens.
Di Yang +6 more
doaj +1 more source
The Omnicausal Model Reveals the Highly Polyfactorial Nature of Complex Diseases. [PDF]
Genet EpidemiolABSTRACT Mendelian randomization (MR) is a human genetics method for inferring causal relationships between risk factors and diseases. A common focus of MR studies has been on the causal inference of a single risk factor on a single disease. This has led to the successful discovery of numerous causal risk factors for disease.
Márquez-Luna C +4 more
europepmc +2 more sources
Nucleic Acids Research, 2013 The Mouse Phenome Database (MPD; phenome.jax.org) was launched in 2001 as the data coordination center for the international Mouse Phenome Project. MPD integrates quantitative phenotype, gene expression and genotype data into a common annotated framework to facilitate query and analysis.
Grubb, Stephen C +2 more
openaire +3 more sources
Phenotypic profiling of ABC transporter coding genes in Myxococcus xanthus
Frontiers in Microbiology, 2014 Information about a gene sometimes can be deduced by examining the impact of its mutation on phenotype. However, the genome-scale utility of the method is limited because, for nearly all model organisms, the majority of mutations result in little or no ...
Jinyuan eYan +4 more
doaj +1 more source
Background Glycated hemoglobin (HbA1c) measures the average blood sugar level over the past three months. As a vital biomarker of blood glucose levels, it is used to diagnose Type-2 diabetes mellitus (T2D) and monitor glycemic control.
Daudi Jjingo (197635) +11 more
core +5 more sources
Immunity & Ageing, 2022 Background The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are readily available circulatory immunity markers that are associated with components of frailty.
Hui Zhang +9 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Neuron apoptosis is a pivotal process for brain damage in cerebral ischemia. Dot1L (disruptor of telomeric silencing 1‐like) is only known histone H3K79 methyltransferase.
Jinghuan Wang +6 more
doaj +1 more source