Results 11 to 20 of about 30,200 (240)
Trends in Genetics, 2008 Human phenomics is about to come of age with studies that systematically assess the overlap and relationships among all human genetic diseases. A recent study by Andrey Rzhetsky and colleagues illustrates the power of phenomics by revealing links between conditions that were thought to be distinct, suggesting that they share a genetic basis.
Oti, M.O., Huynen, M.A., Brunner, H.G.
openaire +4 more sources
Nucleic Acids Research, 2009 The Mouse Phenome Database (MPD; http://www.jax.org/phenome) is an open source, web-based repository of phenotypic and genotypic data on commonly used and genetically diverse inbred strains of mice and their derivatives. MPD is also a facility for query, analysis and in silico hypothesis testing.
Grubb, S C +3 more
core +5 more sources
Genetica, 2004 The laboratory mouse is the organism of choice for many studies in biology and medicine. Reliable phenotypic data are essential for the full utility of genotypic information emerging from efforts to sequence human and mouse genomes. The Mouse Phenome Project has been organized to help accomplish this task by establishing a collection of baseline ...
Bogue, M A, Grubb, S C
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Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans [PDF]
, 2023 Background: The variation in the rate at which humans age may be rooted in early events acting through the genomic regions that are influenced by such events and subsequently are related to health phenotypes in later life.
Y Zeng (7803473) +16 more
core +6 more sources
Phenomics, 2023 AbstractHuman phenomics is defined as the comprehensive collection of observable phenotypes and characteristics influenced by a complex interplay among factors at multiple scales. These factors include genes, epigenetics at the microscopic level, organs, microbiome at the mesoscopic level, and diet and environmental exposures at the macroscopic level. “
Lizhen Lan +13 more
openaire +2 more sources
Commentary on: Genetic predictors of GLP1 receptor agonist weight loss and side effects (Nature volume 653, pages 770-775 (2026)). [PDF]
J Diabetes InvestigJournal of Diabetes Investigation, EarlyView.
Toda G, Yamauchi T.
europepmc +2 more sources
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Frontiers in Plant Science, 2021 In conjunction with big data analysis methods, plant omics technologies have provided scientists with cost-effective and promising tools for discovering genetic architectures of complex agronomic traits using large breeding populations.
Mohsen Yoosefzadeh-Najafabadi +4 more
doaj +1 more source
Phenome-wide associations with genetically predicted height in non-Hispanic White individuals.
, 2022 Plot of phecodes versus -log10(p-value) for association with genetically-predicted height in non-Hispanic White participants in MVP. Phecodes were limited to single decimal place for clarity (e.g., 427.2 for atrial fibrillation or flutter is shown but ...
Kyong-Mi Chang (267170) +23 more
core +1 more source
Phenome-wide associations with genetically predicted height in non-Hispanic Black individuals.
, 2022 Plot of phecodes versus -log10(p-value) for association with genetically-predicted height in non-Hispanic Black participants in MVP. Phecodes were limited to single decimal place for clarity (e.g., 427.2 for atrial fibrillation or flutter is shown but ...
Kyong-Mi Chang (267170) +23 more
core +1 more source