Results 31 to 40 of about 30,931 (193)

Histone methyltransferase Smyd2 contributes to blood‐brain barrier breakdown in stroke

Clinical and Translational Medicine, 2022
Background The blood‐brain barrier (BBB) plays a principal role in the healthy and diseased central nervous systems, and BBB disruption after ischaemic stroke is responsible for increased mortality.
Jinghuan Wang, Wen Zhong, Qianwen Cheng, Chenxi Xiao, Jie Xu, Zhenghua Su, Haibi Su, Xinhua Liu   +7 more
doaj   +1 more source

The effects of adverse childhood experiences on depression and suicidal behaviors are partially mediated by neuroticism: A subclinical manifestation of major depression

Frontiers in Psychiatry, 2023
IntroductionNeuroticism, a personality trait, can predict major depressive disorder (MDD). The current study aims to determine whether a) neuroticism is a feature of the acute state of MDD, including suicidal behaviors (SB); and b) adverse childhood ...
Ketsupar Jirakran, Ketsupar Jirakran, Ketsupar Jirakran, Asara Vasupanrajit, Asara Vasupanrajit, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes   +12 more
doaj   +1 more source

Pan-transcriptome analysis of pine wilt disease-resistant and susceptible Pinus species and a hybrid

Frontiers in Genetics
Pine trees, globally distributed and economically vital evergreen conifers, are threatened by pine wilt disease (PWD) attributed to the pine wood nematode (PWN).
Bae Young Choi, Dayoung Lee, Jaegyeong Jung, Yang-Gil Kim, Youn-Il Park, Kyu-Suk Kang, Donghwan Shim, Donghwan Shim   +7 more
doaj   +1 more source

Phenome-wide significant phenotypes in MGI identified using various PRS construction strategies^a.

, 2019
Phenome-wide significant phenotypes in MGI identified using various PRS construction strategiesa.
Stephanie E. Moser (6836720), Bhramar Mukherjee (90346), Peter VandeHaar (6836696), Sarah A. Gagliano Taliun (6836708), Jonathon LeFaive (6836711), Thomas T. Klumpner (6836717), Erin O. Kaleba (6836714), Sachin Kheterpal (5538692), Robert B. Peng (6836699), Sayantan Das (1734532), Lauren J. Beesley (6836693), Stephen B. Gruber (108155), Maxwell Salvatore (6836702), Matthew Zawistowski (6836705), Lars G. Fritsche (162272), Victoria M. Blanc (6836723), Chad M. Brummett (6338336), Gonçalo R. Abecasis (36598)   +17 more
core   +1 more source

Methodology in phenome-wide association studies:a systematic review [PDF]

, 2021
Phenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic review aims to summarise the PheWAS methodology, discuss the advantages and challenges of ...
Zhang, Xiaomeng, Meng, Xiangrui, Georgiou, Andrea, Li, Xue, Yu, Lili, Theodoratou, Evropi; id_orcid, Campbell, Harry; id_orcid, Koskeridis, Fotios, Wang, Lijuan, Xiaomeng Zhang, Fotios Koskeridis, Andrea Georgiou, Harry Campbell, Evropi Theodoratou, Lili Yu, Xiangrui Meng, Lijuan Wang, Xue Li   +17 more
core   +1 more source

SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases

Clinical and Translational Medicine, 2021
Background The methylation of lysine residues has been involved in the multiple biological and diseases processes. Recently, some particular non‐histone proteins have been elucidated to be methylated by SMYD2, a SET and MYND domain protein with lysine ...
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu   +8 more
doaj   +1 more source

Brooding and neuroticism are strongly interrelated manifestations of the phenome of depression

Frontiers in Psychiatry, 2023
IntroductionWe found that neuroticism may be identified as a subclinical manifestation of the phenome of depression, comprising depressive and anxiety symptoms, and suicidal behaviors.
Asara Vasupanrajit, Asara Vasupanrajit, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Ketsupar Jirakran, Ketsupar Jirakran, Ketsupar Jirakran, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul   +16 more
doaj   +1 more source

Summary statistics for: Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans

, 2023
Summary statistics of single POE-CpG based and POE-CpG co-methylation module based phenome-wide association analyses for the manuscript "Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate ...
Chenhao,Gao, Kathryn, Evans, Xueyi, Shen, Pau, Navarro, Mark, Adams, Rosie, Walker, Ying, Liu, Carmen, Amador, Xiaomeng, Bai, Archie, Campbell, Rebecca, Madden, Miaoxin, Li, David, Porteous, Andrew, McIntosh, Caroline, Hayward, Yanni, Zeng, Chris, Haley   +16 more
core   +1 more source

Coefficient of variation of mouse strain data sets submitted to the Mouse Phenome Database (https://phenome.jax.org).

, 2023
Coefficient of variation of mouse strain data sets submitted to the Mouse Phenome Database (https://phenome.jax.org).
Christian Heumann (487880), Bernhard Aigner (476265)   +1 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source