Results 31 to 40 of about 30,200 (240)

Inhibition of the cardiac fibroblast-enriched histone methyltransferase Dot1L prevents cardiac fibrosis and cardiac dysfunction

Cell & Bioscience, 2022
Background Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is the catalytic enzyme required for
Jie Xu, Jinghuan Wang, Fen Long, Wen Zhong, Haibi Su, Zhenghua Su, Xinhua Liu   +6 more
doaj   +1 more source

Histone methyltransferase Smyd2 contributes to blood‐brain barrier breakdown in stroke

Clinical and Translational Medicine, 2022
Background The blood‐brain barrier (BBB) plays a principal role in the healthy and diseased central nervous systems, and BBB disruption after ischaemic stroke is responsible for increased mortality.
Jinghuan Wang, Wen Zhong, Qianwen Cheng, Chenxi Xiao, Jie Xu, Zhenghua Su, Haibi Su, Xinhua Liu   +7 more
doaj   +1 more source

The effects of adverse childhood experiences on depression and suicidal behaviors are partially mediated by neuroticism: A subclinical manifestation of major depression

Frontiers in Psychiatry, 2023
IntroductionNeuroticism, a personality trait, can predict major depressive disorder (MDD). The current study aims to determine whether a) neuroticism is a feature of the acute state of MDD, including suicidal behaviors (SB); and b) adverse childhood ...
Ketsupar Jirakran, Ketsupar Jirakran, Ketsupar Jirakran, Asara Vasupanrajit, Asara Vasupanrajit, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes   +12 more
doaj   +1 more source

Pan-transcriptome analysis of pine wilt disease-resistant and susceptible Pinus species and a hybrid

Frontiers in Genetics
Pine trees, globally distributed and economically vital evergreen conifers, are threatened by pine wilt disease (PWD) attributed to the pine wood nematode (PWN).
Bae Young Choi, Dayoung Lee, Jaegyeong Jung, Yang-Gil Kim, Youn-Il Park, Kyu-Suk Kang, Donghwan Shim, Donghwan Shim   +7 more
doaj   +1 more source

SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases

Clinical and Translational Medicine, 2021
Background The methylation of lysine residues has been involved in the multiple biological and diseases processes. Recently, some particular non‐histone proteins have been elucidated to be methylated by SMYD2, a SET and MYND domain protein with lysine ...
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu   +8 more
doaj   +1 more source

Phenome-wide significant phenotypes in MGI identified using various PRS construction strategies^a.

, 2019
Phenome-wide significant phenotypes in MGI identified using various PRS construction strategiesa.
Stephanie E. Moser (6836720), Bhramar Mukherjee (90346), Peter VandeHaar (6836696), Sarah A. Gagliano Taliun (6836708), Jonathon LeFaive (6836711), Thomas T. Klumpner (6836717), Erin O. Kaleba (6836714), Sachin Kheterpal (5538692), Robert B. Peng (6836699), Sayantan Das (1734532), Lauren J. Beesley (6836693), Stephen B. Gruber (108155), Maxwell Salvatore (6836702), Matthew Zawistowski (6836705), Lars G. Fritsche (162272), Victoria M. Blanc (6836723), Chad M. Brummett (6338336), Gonçalo R. Abecasis (36598)   +17 more
core   +1 more source

Brooding and neuroticism are strongly interrelated manifestations of the phenome of depression

Frontiers in Psychiatry, 2023
IntroductionWe found that neuroticism may be identified as a subclinical manifestation of the phenome of depression, comprising depressive and anxiety symptoms, and suicidal behaviors.
Asara Vasupanrajit, Asara Vasupanrajit, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Michael Maes, Ketsupar Jirakran, Ketsupar Jirakran, Ketsupar Jirakran, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul, Chavit Tunvirachaisakul   +16 more
doaj   +1 more source

Centre de ressources partagées PHENOME-EMPHASIS

The PHENOME-EMPHASIS resource centre is an open and freely accessible web platform that enables the EMPHASIS community to share semantic resources containing descriptions of poolable elements (genetic resources, variables, etc.) produced by the plant ...
Tardieu, François, Neveu, Pascal, Kazemipour-Ricci, Farzaneh, Tireau, Anne, Chapuis, Romain, Alic, Isabelle, Adam, Boris, B., Burger, Philippe   +7 more
core   +4 more sources

Mapping gene associations in human mitochondria using clinical disease phenotypes [PDF]

, 2009
Nuclear genes encode most mitochondrial proteins, and their mutations cause diverse and debilitating clinical disorders. To date, 1,200 of these mitochondrial genes have been recorded, while no standardized catalog exists of the associated clinical ...
Curt Scharfe, Allen, Edward A., Enns, Gregory M., Guan-Cheng Li, Henry Horng-Shing Lu, Lu, Henry Horng-Shing, Neuenburg, Jutta K., Ronald W. Davis, Jutta K Neuenburg, Tina M. Cowan, Cowan, Tina M., Thomas Klopstock, Jutta K. Neuenburg, Klopstock, Thomas, Tina M Cowan, Scharfe, Curt, Li, Guan-Cheng, Edward A Allen, Ronald W Davis, Edward A. Allen, Davis, Ronald W., Gregory M Enns, Gregory M. Enns   +22 more
core   +1 more source

Principles of phenomics in endometriosis [PDF]

Human Reproduction Update, 2012
Endometriosis has been associated with specific morphometric characteristics and pigmentary traits. The purpose of this study was to systematically review prior publications dealing with this aspect in order to revisit phenotypic information in the context of phenomics principles.Comprehensive searches of Pubmed, Medline and Embase were conducted to ...
P. Vigano, E. Somigliana, P. Panina, E. Rabellotti, P. Vercellini, M. Candiani   +5 more
openaire   +2 more sources