Results 141 to 150 of about 2,449,755 (371)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Studies on the control of pyrimidine biosynthesis in human diploid cell strains, I. Effect of 6-azauridine on cellular phenotype. [PDF]

, 1967
L. Pinsky, Robert S. Krooth
openalex   +1 more source

Asthma Phenotypes

Seminars in Respiratory and Critical Care Medicine, 2012
The identification of phenotypes of asthma has a long history, but previous classifications have not identified clinically important differences in pathology, natural history, or treatment response. Progress has accelerated recently, fueled by the development of new techniques to assess airway disease, particularly noninvasive techniques to assess ...
openaire   +3 more sources

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

The Effect of Matricaria chamomilla Alcoholic Extract on Phenotype Detection of Efflux Pumps of Methicillin Resistant Staphylococcus aureus (MRSA) Isolated from Skin lesions

Iranian Journal of Medical Microbiology, 2019
Background and Aims: Methicillin-resistant Staphylococcus aureus strains are resistant to many antibiotics. One of the major causes of drug resistance in bacteria is the efflux pumps.
Pargol Abdi, Maasoumeh Mahdavi Ourtakand, Sahar Honarmand Jahromy   +2 more
doaj  

Theoretical Consequences of Truncation Selection Based on the Individual Phenotype [PDF]

, 1960
B Griffing
openalex   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

CYP2D6 GENETIC POLYMORPHISM AND EXTRAPYRAMIDAL SIDE EFFECTS OF ANTIPSYCHOTIC DRUGS

Zdravniški Vestnik, 2002
Background. Antipsychotics and also some other psychiatric and some non-psychiatric drugs are known to cause extrapyramidal symptoms. Some of these symptoms, e.g.
Vita Dolžan, Blanka Kores-Plesničar
doaj  

Quantitative population-epigenetics in screening and development of regulator-active compounds

Julius-Kühn-Archiv, 2012
Quantitative (Population-) Epigenetics describes the variability observed in characters due to factors in the environment induced primarily by the gamut of chemical compounds screened for regulatory efficacy.
Stauß, Reinhold
doaj   +1 more source