Results 121 to 130 of about 26,955,799 (314)

Top-ranked gene-phenotype-MOI relations reported by phenogenon.

, 2020
Top-ranked gene-phenotype-MOI relations reported by phenogenon.
Nikolas Pontikos (4611358), Gavin Arno (4611343), Dayyanah Sumodhee (8693898), Andrew Webster (3471632), Jing Yu (81085), Yu Fujinami (8693895), Susan Downes (8693901), Kaoru Fujinami (4568248), Ismail Moghul (4369453), Cian Murphy (2940333)   +9 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Phenotype data (mutation rates, growth curves, etc)

, 2018
Phenotype data (mutation rates, growth curves ...
Wagner, Andreas, Andreas Wagner (3323), Aguilar-Rodríguez, José, Paul Sniegowski (3768517), Kathleen Sprouffske (82909), José Aguilar-Rodríguez (5151185), Sprouffske, Kathleen, Sniegowski, Paul   +7 more
core   +1 more source

Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos

microPublication Biology, 2020
Fan-Suo Geng, Elisa de la Calle-Mustienes, José Luis Gómez-Skarmeta, Ryan Lister, Ozren Bogdanovic   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The effect of microbiome on social spacing in Drosophila melanogaster depends on genetic background and sex

microPublication Biology
The gut microbiome modulates many essential functions including metabolism, immunity, and behaviour. Specifically, within behaviour, social behaviours such as sociability, aggregation, mating preference, avoidance, oviposition, and aggression are known ...
Yanira Jiménez-Padilla, Yen Chan, M. Sol Aletta, Marc-André Lachance, Anne F Simon   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Drosophila Robo3 guides longitudinal axons partially independently of its cytodomain

microPublication Biology
Drosophila Robo3 is an axon guidance receptor that regulates longitudinal axon tract formation in the embryonic ventral nerve cord. Robo3 is thought to guide longitudinal axons by signaling repulsion in response to Slit.
Jessie Agcaoili, Timothy A. Evans
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Supplementary Table S2-RNAi Screen in mouse preimplantation embryos-59 obvious phenotype genes

, 2016
Wei Cui et al.
Cui, W (via Mendeley Data), Cui, Wei
core   +1 more source