Results 171 to 180 of about 26,955,799 (314)

Phenotyping Endometriosis from Observational Health Data

, 2019
The signs and symptoms of many diseases remain poorly characterized. For these types of conditions, the constellation of symptoms experienced by patients are not adequately described, nor are the signs and symptoms specific to the condition well-defined. These features define an enigmatic disease.
openaire   +2 more sources

Genetic mapping of shnE.3.2 in Drosophila melanogaster

microPublication Biology, 2019
Kayla Bieser, Jamie Siders Sanford, Ken Saville, Katherine F. Arreola, Zachary T. Ayres, David Basulto, Serena Benito, Christopher J. Breen, Julian A. Brix, Nicole Brown, Krissa K. Burton, Taree M. Chadwick, Matthew Chen, Katherine Chu, Beverly L. Corbett, Zerrick Dill, Meghan A. Faughender, Ashlynn D. Hickey, Joshua S. Julia, Shannon S. Kelty, Briggette B.K. Jobs, Bryce A. Krason, Brian Lam, Colin L. McCullough, Bryanna R. McEwen, Julian L. McKenzie, Kayla R. McQuinn, Chloe M. Moritz, Kristina E. Myers, Elizabeth M. Naugle, Ashley M. Nutter, Danielle Q. O'Conke, Megan T. O'Grondik, Kriya B. Patel, Sydney M. Rudowski, Emma N. Sberna, Gunner M. Stall, Tad L. Steiner, Eda Tanriverdi, Natalie Torres Patarroyo, Virginia L. Traster, Leo P. Tsai, Andrew J. Valenti, Mariela M. Villegas, Samantha M. Voors, Kierra K. Watson, Megan E. Wright, Jacob D. Kagey   +47 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Phenotype and genotype data sharing

, 2019
The ability to efficiently share and publish data, and especially phenotype and genotype data, following the FAIR principles is a challenging objective that has been encompassed by the Plant community, and especially in European infrastructures like Emphasis and Elixir. This lead to the conception of several mean for data sharing, with a focus on Plant
openaire   +2 more sources

The Xenopus phenotype ontology: bridging model organism phenotype data to human health and development. [PDF]

BMC Bioinformatics, 2022
Fisher ME, Segerdell E, Matentzoglu N, Nenni MJ, Fortriede JD, Chu S, Pells TJ, Osumi-Sutherland D, Chaturvedi P, James-Zorn C, Sundararaj N, Lotay VS, Ponferrada V, Wang DZ, Kim E, Agalakov S, Arshinoff BI, Karimi K, Vize PD, Zorn AM.   +19 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Real-life experience with inotersen in hereditary transthyretin amyloidosis with late-onset phenotype: Data from an early-access program in Italy. [PDF]

Eur J Neurol, 2022
Luigetti M, Antonini G, Di Paolantonio A, Gentile L, Grandis M, Leonardi L, Lozza A, Manganelli F, Manganelli F, Mazzeo A, Mussinelli R, My F, Obici L, Maria Pennisi E, Romozzi M, Russo M, Sabatelli M, Salvalaggio A, Tagliapietra M, Tozza S.   +19 more
europepmc   +1 more source

Drosophila Plc21C is involved in calcium wave propagation during egg activation

microPublication Biology, 2020
Qinan Hu, Adriana N. Vélez-Avilés, Mariana F. Wolfner   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Challenges for FAIR-compliant description and comparison of crop phenotype data with standardized controlled vocabularies. [PDF]

Database (Oxford), 2021
Andrés-Hernández L, Halimi RA, Mauleon R, Mayes S, Baten A, King GJ.   +5 more
europepmc   +1 more source