Results 221 to 230 of about 26,955,799 (314)

Association between cognitive reserve proxies and frailty phenotype: data from UK Biobank. [PDF]

Geroscience
Lorenzo-López L, Cibeira N, Hemadeh A, López-López R, Lema-Arranz C, Maseda A, Fernández-Bertólez N, Costa S, Pásaro E, Valdiglesias V, Millán-Calenti JC, Laffon B.   +11 more
europepmc   +1 more source

The Effect of an Environmentally Relevant Phthalate Mixture on Primordial Germ Cells of Xenopus laevis Embryos

microPublication Biology, 2018
Nathalie Lancy Momplaisir, Aurora Turgeon, Jodi Flaws, Jing Yang   +3 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Helping authors produce FAIR taxonomic data: evaluation of an author-driven phenotype data production prototype. [PDF]

Database (Oxford)
Zhang L, Starr J, Ford B, Reznicek A, Zhou Y, Léveillé-Bourret É, Lacroix-Carignan É, Cayouette J, Smith TW, Sutherland D, Catling P, Saarela JM, Cui H, Macklin J.   +13 more
europepmc   +1 more source

Overexpression of hindsight in sensory organ precursors is associated with a transformation of campaniform sensilla to microchaetae in the Drosophila wing

microPublication Biology, 2019
Krzysztof Szablewski, Bruce H Reed
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation. [PDF]

Nat Hum Behav
Carey CE, Shafee R, Wedow R, Elliott A, Palmer DS, Compitello J, Kanai M, Abbott L, Schultz P, Karczewski KJ, Bryant SC, Cusick CM, Churchhouse C, Howrigan DP, King D, Davey Smith G, Neale BM, Walters RK, Robinson EB.   +18 more
europepmc   +1 more source

GWAS Central: a comprehensive resource for the discovery and comparison of genotype and phenotype data from genome-wide association studies. [PDF]

Nucleic Acids Res, 2020
Beck T, Shorter T, Brookes AJ.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Loss of nucleosome remodelers CHRAC/ACF does not sensitize early Drosophila embryos to X-rays

microPublication Biology, 2020
Alessandro Scacchetti, Peter B. Becker
doaj   +1 more source